Targeted Intraoperative Radiotherapy Tumour Bed Boost during Breast-Conserving Surgery after Neoadjuvant Chemotherapy - a Subgroup Analysis of Hormone Receptor-Positive HER2-Negative Breast Cancer

Introduction: In a previous study our group showed a beneficial effect of targeted intraoperative radiotherapy (TARGIT-IORT) as an intraoperative boost on overall survival after neoadjuvant chemotherapy (NACT) compared to an external boost (EBRT). In this study we present the results of a detailed subgroup analysis of the hormone receptor (HR)-positive HER2-negative patients. Methods: In this cohort study involving 46 patients with HR-positive HER2-negative breast cancer after NACT, we compared the outcomes of 21 patients who received an IORT boost to those of 25 patients treated with an EBRT boost. All patients received whole breast radiotherapy. Results: Median follow-up was 49 months. Whereas disease-free-survival and breast cancer-specific mortality were not significantly different between the groups, the 5-year Kaplan-Meier estimate of overall mortality was significantly lower by 21% with IORT, p = 0.028. Non-breast cancer-specific mortality was significantly lower by 16% with IORT, p = 0.047. Conclusion: Although our results have to be interpreted with caution, we have shown that the improved overall survival demonstrated previously could be reproduced in the HR-positive HER2-negative subgroup. These data give further support to the inclusion of such patients in the TARGIT-B (Boost) randomised trial that is testing whether IORT boost is superior to EBRT boost

Patient-derived xenograft (PDX) models in basic and translational breast cancer research

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research

25th annual computational neuroscience meeting: CNS-2016

The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong

Johann Heinrich Pestalozzi: Sämtliche Werke. Kritische Ausgabe. Herausgegeben vom Pestalozzianum Zürich unter der Leitung von Hans Gehrig und vom Pädagogischen Institut der Universität Zürich unter der Leitung von Fritz-Peter Hager. […] [Sammelrezension]

Sammelrezension von: 1. Johann Heinrich Pestalozzi: Sämtliche Werke. Kritische Ausgabe. Herausgegeben vom Pestalozzianum Zürich unter der Leitung von Hans Gehrig und vom Pädagogischen Institut der Universität Zürich unter der Leitung von Fritz-Peter Hager. 1.1. Bd. 17 B. Journal für die Erziehung 1807 mit nachgelassenem Text zu den darin enthaltenen Briefen der damals geplanten „Neuen Auflage der Schrift: Wie Gertrud ihre Kinder lehrt". Bearbeitet unter Mitwirkung von Heinz Gallmann, Basil Rogger und Kurt Werder sowie unter Berücksichtigung der Vorarbeiten von Emanuel Dejung von Stefan Graber. Zürich: Verlag Neue Zürcher Zeitung 1996. 557 S. 1.2. Bd. 29: Nachtrag. Anonyme Drucke und nachgelassene Texte aus den Jahren 1781 bis 1818. Bearbeitet unter Mitwirkung von Heinz Gallmann, Stefan Graber und Basil Rogger sowie unter Berücksichtigung der Vorarbeiten von Emanuel Dejung von Kurt Werder. Zürich: Verlag Neue Zürcher Zeitung 1996. 367 S. 2. Johann Heinrich Pestalozzi: Sämtliche Briefe. Kritische Ausgabe. Herausgegeben vom Pestalozzianum Zürich unter der Leitung von Hans Gehrig und vom Pädagogischen Institut der Universität Zürich unter der Leitung von Fritz-Peter Hager. Bd. 14: Nachtrag. Briefe und briefähnliche Dokumente aus den Jahren 1767 bis 1826. Bearbeitet unter Mitwirkung von Heinz Gallmann, Stefan Graber und Basil Rogger sowie unter Berücksichtigung der Vorarbeiten von Emanuel Dejung von Kurt Werder. Zürich: Verlag Neue Zürcher Zeitung 1995. 471 S

The school museum as a project of both the science of history and didactics. The conception of the school museums at Ichenhausen (district of Günzburg) and at Nuremberg

Nach der Skizzierung der bis 1881 zurückreichenden Schulmuseumstradition in Bayern werden die Konzepte des Bayerischen Schulmuseums Ichenhausen und des Schulmuseums der Universität Erlangen-Nürnberg erläutert. Dabei ergeben sich besondere wissenschaftliche und didaktische Probleme; in Ichenhausen bei dem Versuch, die „Schulgeschichte“ im Zusammenhang der Kulturentwicklung wenigstens exemplarisch von der Vorzeit bis in die Gegenwart darzustellen, im Nürnberger Museum mit den Vorhaben, nicht nur mittelfränkische Schulgeschichte und die Geschichte der Sonderschule, der Berufsschule und der Höheren Schulen, sondern auch gesellschaftliche, ökonomische und andere Funktionen von Schule am Beispiel der Situation der Entwicklungsländer vor Augen zu führen. (DIPF/Orig.

Fritz-Peter Hager/Daniel Tröhler (Hrsg.): Neue Pestalozzi-Studien. Bd. 1: Anna Pestalozzis Tagebuch - Käte Silber: Anna Pestalozzi und der Frauenkreis um Pestalozzi. Bern/Stuttgart: Haupt 1993 [Rezension]

Rezension von: Fritz-Peter Hager/Daniel Tröhler (Hrsg.): Neue Pestalozzi-Studien. Bd. 1: Anna Pestalozzis Tagebuch - Käte Silber: Anna Pestalozzi und der Frauenkreis um Pestalozzi. Bern/Stuttgart: Haupt 1993, 242 S

Einfluss des Sauerstoffgehalts in Kupfer auf die Reaktivitaet von diffusionsverschweissten Cu/#alpha#-Al_2O_3-Grenzflaechen

Available from TIB Hannover: RR 6084(51) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman