Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS.

peer reviewedAllogeneic hematopoietic stem cell transplantation remains the best curative option for higher-risk myelodysplastic syndrome. The presence of monosomal karyotype and/or complex karyotype abnormalities predicts inferior survival after allo-SCT in MDS patients. Haploidentical allo-SCT has been increasingly used in acute leukemia (AL) and has similar results as using HLA-matched donors, but data on higher-risk MDS is sparse. We compared outcomes in 266 patients with higher-risk MDS after HLA-matched sibling donor (MSD, n = 79), HLA-matched unrelated donor (MUD, n = 139) and HLA haploidentical donor (HID, n = 48) from 2010 to 2019. Median donor age differed between the three groups (p < 0.001). The overall survival was significantly different between the three groups with a better OS observed in the MUD group (p = 0.014). This observation could be explained by a higher progression-free survival with MUD (p = 0.014). The cumulative incidence of grade 2-4 acute GvHD was significantly higher in the HID group (p = 0.051). However, in multivariable analysis, patients transplanted using an HID had comparable mortality to patients transplanted using a MUD (subdistribution hazard ratio [sHR]: 0.58 [0.32-1.07]; p = 0.080) and a MSD ([sHR]: 0.56 [0.28-1.11]; p = 0.094). MUD do not remain a significant positive predictor of survival, suggesting that beyond the donor-recipient HLA matching, the donor age might impact recipient outcome

Bone marrow graft versus peripheral blood graft in haploidentical hematopoietic stem cells transplantation: a retrospective analysis in1344 patients of SFGM-TC registry.

peer reviewedThe use of peripheral blood (PB) or bone marrow (BM) stem cells graft in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide (PTCy) for graft-versus-host disease (GVHD) prophylaxis remains controversial. Moreover, the value of adding anti-thymoglobulin (ATG) to PTCy is unknown. A total of 1344 adult patients received an unmanipulated haploidentical transplant at 37 centers from 2012 to 2019 for hematologic malignancy. We compared the outcomes of patients according to the type of graft, using a propensity score analysis. In total population, grade II-IV and III-IV acute GVHD (aGVHD) were lower with BM than with PB. Grade III-IV aGVHD was lower with BM than with PB + ATG. All outcomes were similar in PB and PB + ATG groups. Then, in total population, adding ATG does not benefit the procedure. In acute leukemia, myelodysplastic syndrome and myeloproliferative syndrome (AL-MDS-MPS) subgroup receiving non-myeloablative conditioning, risk of relapse was twice greater with BM than with PB (51 vs. 22%, respectively). Conversely, risk of aGVHD was greater with PB (38% for aGVHD II-IV; 16% for aGVHD III-IV) than with BM (28% for aGVHD II-IV; 8% for aGVHD III-IV). In this subgroup with intensified conditioning regimen, risk of relapse became similar with PB and BM but risk of aGVHD III-IV remained higher with PB than with BM graft (HR = 2.0; range [1.17-3.43], p = 0.012)

Aux portes de l'Orient: la Lagune de Venise-Istrie et Dalmatie-Herzégovine et Bosnie- Montenegro - La Côte turque- Corfou.

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Sous la tente : camps de vacances de la Fédération française des étudiants chrétiens

par Ed. Maury, Ch. Grauss et les campeurs ; ill. de F.L. SchmiedJustification du tirage: - 25 ex. sur japon impérial numérotés 1 à 25, avec suite d'épreuves des gravures, - 200 ex. sur hollande numérotés 26 à 225, - 800 ex. sur papier alf

19. Laboratoire de botanique pratique du Muséum d'histoire naturelle (classifications et familles naturelles)

Bureau Edouard, Poisson Jules, Maury . 19. Laboratoire de botanique pratique du Muséum d'histoire naturelle (classifications et familles naturelles). In: Rapport sur l'École pratique des hautes études, 1884-1885. 1884. pp. 127-128

19. Laboratoire de botanique pratique du Muséum d'histoire naturelle (Classifications et familles naturelles)

Bureau Edouard, Poisson Jules, Maury . 19. Laboratoire de botanique pratique du Muséum d'histoire naturelle (Classifications et familles naturelles). In: Rapport sur l'École pratique des hautes études, 1883-1884. 1883. pp. 143-145

19. Laboratoire de botanique pratique du Muséum d'histoire naturelle (classifications et familles naturelles)

Bureau Edouard, Poisson Jules, Maury . 19. Laboratoire de botanique pratique du Muséum d'histoire naturelle (classifications et familles naturelles). In: Rapport sur l'École pratique des hautes études, 1884-1885. 1884. pp. 127-128

19. Laboratoire de botanique pratique du Muséum d'histoire naturelle (classifications et familles naturelles)

Bureau Edouard, Poisson Jules, Maury Alfred. 19. Laboratoire de botanique pratique du Muséum d'histoire naturelle (classifications et familles naturelles). In: Rapport sur l'École pratique des hautes études, 1882-1883. 1882. pp. 148-150