Changes in weight and CD4 + T cells in HIV / AIDS individuals with antiretroviral, Angola

Introduction: There are several causes that lead to malnutrition in acquired immunodeficiency syndrome. However, cellular immunosuppression with a decrease in CD4 + T lymphocytes represents the main conditioning factor. Objective: to relate antiretroviral changes on body weight and CD4 + T lymphocyte count in HIV / AIDS patients from the province of Benguela, Angola. Method: a case-control study was conducted in 190 adults with HIV / AIDS treated at Benguela Provincial External Bank Hospital, with three months or more of patients treated with antiretroviral (women: 70.5%, mean age: 36 , 1 year,> 35 years with HIV + diagnosis: 46.8%, 3-18 months with antiretroviral: 48.9%). The absolute CD4 + T cell count and weight were measured before starting the therapy (initial value) and at the last visit (final value). The relative changes or gradients (final value - initial value / initial value) of both variables were calculated. A comparison of means for related and independent samples was performed by non-parametric tests. The association between weight gradients and CD4 counts was estimated using the Odds-Ratio and its confidence interval; 95% of confidence was considered for all statistical tests. Results: the mean of weight and absolute CD4 + T cell counts increased significantly after the retroviral therapy (p <0.001). A significant association was found between the weight gradient and the CD4 gradient (OR = 3.61; CI (95%): 1.61-8.11). Conclusion: the relative changes in body weight in individuals suffering from HIV / AIDS as a result of antiretroviral therapy could be used to follow up and monitor the immune response to antiretroviral in countries with shortage of economic resources

Cambios del peso y de las células T CD4+ en sujetos VIH/sida con antirretrovirales. Angola

Introduction: There are several causes that lead to malnutrition in acquired immunodeficiency syndrome. However, cellular immunosuppression with a decrease in CD4 + T lymphocytes represents the main conditioning factor.Objective: to relate antiretroviral changes on body weight and CD4 + T lymphocyte count in HIV / AIDS patients from the province of Benguela, Angola.Method: a case-control study was conducted in 190 adults with HIV / AIDS treated at Benguela Provincial External Bank Hospital, with three months or more of patients treated with antiretroviral (women: 70.5%, mean age: 36 , 1 year,> 35 years with HIV + diagnosis: 46.8%, 3-18 months with antiretroviral: 48.9%). The absolute CD4 + T cell count and weight were measured before starting the therapy (initial value) and at the last visit (final value). The relative changes or gradients (final value - initial value / initial value) of both variables were calculated. A comparison of means for related and independent samples was performed by non-parametric tests. The association between weight gradients and CD4 counts was estimated using the Odds-Ratio and its confidence interval; 95% of confidence was considered for all statistical tests.Results: the mean of weight and absolute CD4 + T cell counts increased significantly after the retroviral therapy (p 35 años con diagnóstico VIH+: 46,8%; 3-18 meses con antirretrovirales: 48,9%). Se midió el peso, y el conteo absoluto de las células T CD4+ antes de iniciar la terapia (valor inicial) y en la última consulta (valor final). Se calcularon los cambios relativos o gradientes (valor final - valor inicial/valor inicial) de ambas variables. Se realizó comparación de medias para muestras relacionadas e independientes por pruebas no paramétricas. La asociación entre los gradientes del peso y conteo CD4 se estimó mediante el Odds-Ratio (OR) y su intervalo de confianza. Se consideró el 95% de confianza para todas las pruebas estadísticas.Resultados: las medianas del peso y conteo absoluto de las células T CD4+ aumentaron significativamente después de la terapia (p< 0,001). Se encontró asociación significativa entre el gradiente del peso y el gradiente de los CD4 (OR=3,61; IC (95%): 1,61-8,11).Conclusión: los cambios relativos del peso corporal en los sujetos con VIH/sida a consecuencia de la terapia antirretroviral pudieran ser utilizados en el seguimiento y monitoreo de la respuesta inmunológica a los antirretrovirales en países de bajos recursos económicos