22 research outputs found
Binding of lac repressor induces different conformational changes on operator and non-operator DNAs
Interaction between the peptide lysyl-tryptophanyl-lysine and copolynucleotides of adenine and uracil: Selectivity of interaction
New Synchrotron Radiation Circular Dichroism end-station on DISCO beamline at SOLEIL synchrotron for biomolecular analysis
Interaction between Cisplatin-modified DNA and the HMG Boxes of HMG 1: DNase I Footprinting and Circular Dichroism
International audienceThe interactions between the two boxes A and B of HMG 1 and cis-diamminedichloroplatinum(II)-modified DNA containing a single intrastrand cross-link at the d(GpG) site were studied by DNase I footprinting and circular dichroism. The DNAase I cleavage patterns of the HMG box-platinated DNA complexes are identical, the two boxes inhibiting the DNase I cutting over at least 15 and 12 nucleotide residues in the platinated strand and the complementary strand, respectively. As judged by circular dichroism, the two boxes have the same alpha-helical content (56%) and they induce the same conformational changes in the platinated DNA