Monitoring climatic impacts on the moisture uptake of the first Swiss wildlife bridge made of wood

Wildlife bridges represent a major component of any sustainable strategy to counteract the negative consequences of cutting the natural habitat of wildlife into disconnected parts by motorways and rail. This is especially true for a small and densely populated country such as Switzerland with diverse wildlife scattered through its territory. Up to now all wildlife bridges in Switzerland have been made of concrete with steel reinforcement. The wildlife bridge under investigation here is the first one in Switzerland made of wood-based materials. The idea of building a wildlife bridge by using wood-based materials represents besides a challenging technological endeavor also an ecological progress regarding embodied energy. A further advantage which resulted after realizing the construction, was the short interruption time it needed for installation on a motorway in operation. The most urgent question with respect to the wood-based elements is their moisture uptake when subjected to weather conditions. The present paper reports on a long-term monitoring of this wooden wildlife bridge over a period of approximately 2 years. Different kind of sensors, data from a nearby meteorological station, data regarding hourly number of different kind of vehicles passing beneath the wildlife bridge as well as lab measurements have been used to enable a robust and reliable statement on wooden wildlife bridges subjected to Swiss flatland weather conditions

The Impact of the Introduction of Total Mesorectal Excision on Local Recurrence Rate and Survival in Rectal Cancer: Long-Term Results

Purpose: To investigate the influence of the introduction of total mesorectal excision (TME) on local recurrence rate and survival in patients with rectal cancer. Methods: A total of 171 consecutive patients underwent anterior or abdominoperineal resection for primary rectal cancer. When the TME technique was introduced, the clinical setting, including the surgeons, remained the same. Group 1 (1993-95, n=53) underwent conventional surgery and group 2 (1995-2001, n=118) underwent TME. All patients were followed for 7years or until death. Results: Between the two groups, no statistically significant differences were present with regards to patient-, treatment-, or tumor-related characteristics apart from the time point of radiotherapy. The total local recurrence rates were 11 of 53 (20.8%) in group 1 and 7 of 118 (5.9%) in group 2, and the rates of isolated local recurrences were 6 of 53 (11.3%) in group 1 and 2 of 118 (1.7%) in group 2. Both differences were highly statistically significant. The disease-free survival in groups 1 and 2 was 60.4 and 65.3% at 5years, and 58.5 and 65.3% at 7years, respectively. Excluding patients with synchronous or metachronous distant metastasis from the analysis, both the disease-free survival and the cancer-specific survival were statistically significantly better in group 2 than in group 1. No statistically significant difference between the two groups was detected regarding the overall survival. Conclusions: The introduction of TME led to an impressive reduction of the local recurrence rate. Survival is mainly determined by the occurrence of distant metastasis, but TME seems to improve survival in patients without systemic diseas

A reproducible extrusion printing process with highly viscous nanoparticle inks

Printing of functional materials such as nanoparticle inks is a class of additive fabrication techniques complementary to standard subtractive electronics fabrication techniques such as pcb technology on pcb level or silicon based microelectronics on integrated circuit level. To date the majority of digital printing processes for (micro)electronics is inkjet based. Moreover aerosol jet based printing also establishes itself for printing on non-planar substrates and for materials with higher viscosities. A material deposition technique available since decades and mainly used for dispensing of adhesives and sealing materials is fluid-filament printing. It allows to cover a wide range of materials and viscosities and thus, also holds potential for additive manufacturing of electronics. In this paper we systematically study the influences on fluid filament printing both theoretically taking into account ink and equipment tolerances and experimentally using mainly standard dispensing equipment and two commercial screen printing inks. At the end of the paper we derive recommendations for reproducible printing of conductive lines and pads and give an outlook to printing 2.5D structures

The Advocate

Headlines Include: Laurels For Feerick: An Alumnus To Remember; Crime at Fordham; Who\u27s Next?, Film at 11https://ir.lawnet.fordham.edu/student_the_advocate/1007/thumbnail.jp

SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

K63‐ and Met1‐linked ubiquitylation are crucial posttranslational modifications for TNF receptor signaling. These non‐degradative ubiquitylations are counteracted by deubiquitinases (DUBs), such as the enzyme CYLD, resulting in an appropriate signal strength, but the regulation of this process remains incompletely understood. Here, we describe an interaction partner of CYLD, SPATA2, which we identified by a mass spectrometry screen. We find that SPATA2 interacts via its PUB domain with CYLD, while a PUB interaction motif (PIM) of SPATA2 interacts with the PUB domain of the LUBAC component HOIP. SPATA2 is required for the recruitment of CYLD to the TNF receptor signaling complex upon TNFR stimulation. Moreover, SPATA2 acts as an allosteric activator for the K63‐ and M1‐deubiquitinase activity of CYLD. In consequence, SPATA2 substantially attenuates TNF‐induced NF‐κB and MAPK signaling. Conversely, SPATA2 is required for TNF‐induced complex II formation, caspase activation, and apoptosis. Thus, this study identifies SPATA2 as an important factor in the TNF signaling pathway with a substantial role for the effects mediated by the cytokine

Геоэкологическая характеристика и проект мониторинга зоны влияния вагонного участка Томск АО ФПК Западно-Сибирского филиала АО ФПК (г.Томск)

Объектом исследования является зона влияния вагонного участка Томск АО ФПК Западно-Сибирского филиала АО ФПК (г.Томск). Цель работы – провести комплексный экологический мониторинг в зоне влияния вагонного участка Томск АО ФПК Западно-Сибирского филиала АО ФПК (г.Томск). Основные конструктивные, технологические и технико-эксплуатационные характеристики: составлена карта-схема организации пунктов мониторинга на территории вагонного участка Томск. В процессе исследования проводились следующие виды работ: проект геоэкологического мониторинга на территории вагонного участка Томск АО ФПК Западно-Сибирского филиала АО ФПК (г.Томск). Были рассмотрены следующие вопросы: характеристика района расположения объекта работ, обзор и анализ ранее проведенных работ, геоэкологическая характеристика. На основании полученной информации была обоснована методика и организация работ, выбраны виды, методика, условия проведения и объем проектируемых работ. В качестве специального вопроса были рассмотрены экологические проблемы связанные с воздействием железнодорожного транспорта на окружающую среду. В результате исследования был составлен и выполнен проект геоэкологического мониторинга на территории вагонного участка Томск АО ФПК Западно-Сибирского филиала АО ФПК (г.Томск). Степень внедрения: предлагаемый проект геоэкологического мониторинга может быть принят к исполнению на предприятии для оценки воздействия деятельности на компоненты окружающей среды. Область применения: охрана окружающей среды на предприятии.The object of study is the zone of influence of the railway station Tomsk JSC FPC's West-Siberian branch of JSC FPK (Tomsk). Aim of work - to conduct the complex ecological monitoring on territory of carriage area Tomsk. Basic structural, technological and технико operating descriptions: the map-chart of organization of monitoring points is made on territory of carriage area Tomsk. In the process of research the next types of works were conducted: project of the geoecological monitoring on territory of carriage area Tomsk of propulsion MODULE of ФПК of the западно-сибирского branch of propulsion MODULE ФПК (г.Томск). Next questions were considered: description of district of location of object of works, review and analysis of the before conducted works, geoecological description

Chronic kidney disease induces a systemic microangiopathy, tissue hypoxia and dysfunctional angiogenesis

Chronic kidney disease (CKD) is associated with excessive mortality from cardiovascular disease (CVD). Endothelial dysfunction, an early manifestation of CVD, is consistently observed in CKD patients and might be linked to structural defects of the microcirculation including microvascular rarefaction. However, patterns of microvascular rarefaction in CKD and their relation to functional deficits in perfusion and oxygen delivery are currently unknown. In this in-vivo microscopy study of the cremaster muscle microcirculation in BALB/c mice with moderate to severe uremia, we show in two experimental models (adenine feeding or subtotal nephrectomy), that serum urea levels associate incrementally with a distinct microangiopathy. Structural changes were characterized by a heterogeneous pattern of focal microvascular rarefaction with loss of coherent microvascular networks resulting in large avascular areas. Corresponding microvascular dysfunction was evident by significantly diminished blood flow velocity, vascular tone, and oxygen uptake. Microvascular rarefaction in the cremaster muscle paralleled rarefaction in the myocardium, which was accompanied by a decrease in transcription levels not only of the transcriptional regulator HIF-1 alpha, but also of its target genes Angpt-2, TIE-1 and TIE-2, Flkt-1 and MMP-9, indicating an impaired hypoxia-driven angiogenesis. Thus, experimental uremia in mice associates with systemic microvascular disease with rarefaction, tissue hypoxia and dysfunctional angiogenesis

Lower frequency routine surveillance endomyocardial biopsies after heart transplantation

In heart transplantation (HTx) patients, routine surveillance endomyocardial biopsies (rsEMB) are recommended for the detection of early cardiac allograft rejection. However, there is no consensus on the optimal frequency of rsEMB. Frequent rsEMB have shown a low diagnostic yield in the new era of potent immunosuppressive regimen. Efficacy and safety of lower frequency rsEMB have not been investigated so far. In this retrospective, single centre, observational study we evaluated 282 patients transplanted between 2004 and 2014. 218 of these patients were investigated by rsEMB and symptom-triggered EMB (stEMB). We evaluated EMB results, complications, risk factors for rejection, survival 1 and 5 years as well as incidence of cardiac allograft vasculopathy (CAV) 3 years after HTx. A mean of 7.1 +/- 2.5 rsEMB were conducted per patient within the first year after HTx identifying 7 patients with asymptomatic and 9 patients with symptomatic acute rejection requiring glucocorticoide pulse therapy. Despite this relatively low frequency of rsEMB, only 6 unscheduled stEMB were required in the first year after HTx leading to 2 additional treatments. In 6 deaths among all 282 patients (2.1%), acute rejection could not be ruled out as a potential underlying cause. Overall survival at 1 year was 78.7% and 5-year survival was 74%. Incidence of CAV was 17% at 3-year follow-up. Morbidity and mortality of lower frequency rsEMB are comparable with data from the International Society for Heart and Lung Transplantation (ISHLT) registry. Consensus is needed on the optimal frequency of EMB

EUFOREUM Berlin 2023: Optimizing care for type 2 inflammatory diseases from clinic to AI: A pediatric focus.

The European Forum for Research and Education in Allergy and Airways diseases (EUFOREA) organized its bi-annual forum EUFOREUM in Berlin in November 2023. The aim of EUFOREUM 2023 was to highlight pediatric action plans for prevention and optimizing care for type 2 inflammatory conditions starting in childhood, with a focus on early-stage diagnosis, ensuring neither under- nor overdiagnosis, optimal care, and suggestions for improvement of care. EUFOREA is an international not-for-profit organization forming an alliance of all stakeholders dedicated to reducing the prevalence and burden of chronic respiratory diseases through the implementation of optimal patient care via educational, research, and advocacy activities. The inclusive and multidisciplinary approach of EUFOREA was reflected in the keynote lectures and faculty of the virtual EUFOREUM 2023 (www.euforea.eu/euforeum) coming from the pediatric, allergology, pulmonology, ENT, dermatology, primary health care fields and patients around the central theme of type 2 inflammation. As most type 2 inflammatory conditions may start in childhood or adolescence, and most children have type 2 inflammation when suffering from a respiratory or skin disease, the moment has come to raise the bar of ambitions of care, including prevention, remission and disease modification at an early stage. The current report provides a comprehensive overview of key statements by the faculty of the EUFOREUM 2023 and the ambitions of EUFOREA allowing all stakeholders in the respiratory field to be updated and ready to join forces in Europe and beyond