Total System Performance Assessment: Enhanced Design Alternative IV

The purpose of this calculation is to document total system performance assessment modeling of Enhanced Design Alternative (EDA) Feature IV. Total System Performance Assessment (TSPA) calculations for EDA IV are based on the TSPA-VA Base Case which has been modified with a quartz sand invert, quartz sand backfill, line loading and 21 PWR waste packages that have 2-cm thick titanium grade 7 corrosion resistant material (CRM) drip shields that are placed over a 30 cm thick carbon steel (A5 16) waste package with an integral filler material (CRWMS M&O 1999a & 1999b). This document details the changes and assumptions made to the VA reference Performance Assessment Model (CRWMS M&O 1998a) to incorporate the design changes detailed for EDA IV. The performance measure for this evaluation is the expected value dose-rate history at 20 km from the repository boundary

A user's guide for INPAGF_Launcher.DLL.

Sandia National Laboratories (Sandia), a U.S. Department of Energy National Laboratory, has over 30 years experience in the assessment of radioactive waste disposal and at the time of this publication is providing assistance internationally in a number of areas relevant to the safety assessment of radioactive waste disposal systems. In cooperation with the Republic of Taiwan's Institute of Nuclear Engineering and Research (INER), Sandia National Laboratories (SNL) has developed software that provides an interface between a deterministic far field mass transport code and GoldSim (a commercial software used to conduct Monte Carlo analyses). The SNL developed software enables INER to perform probabilistic simulations for safety analysis and performance assessment of geologic disposal of commercial spent nuclear fuel. The following report details the software design, the steps necessary to use the software, and presents an example application of the paradigm of coupling deterministic codes to a contemporary probabilistic software application

Technique for high axial shielding factor performance of large-scale, thin, open-ended, cylindrical Metglas magnetic shields

Metglas 2705M is a low-cost commercially-available, high-permeability Cobalt-based magnetic alloy, provided as a 5.08-cm wide and 20.3-$\mu$m thick ribbon foil. We present an optimized construction technique for single-shell, large-scale (human-size), thin, open-ended cylindrical Metglas magnetic shields. The measured DC axial and transverse magnetic shielding factors of our 0.61-m diameter and 1.83-m long shields in the Earth's magnetic field were 267 and 1500, for material thicknesses of only 122 $\mu$m (i.e., 6 foil layers). The axial shielding performance of our single-shell Metglas magnetic shields, obtained without the use of magnetic shaking techniques, is comparable to the performance of significantly thicker, multiple-shell, open-ended Metglas magnetic shields in comparable-magnitude, low-frequency applied external fields reported previously in the literature.Comment: 4 pages, 5 figure

Perspectives of Social Justice Activists: Advocating Against Native-themed Mascots, Nicknames, and Logos

This study investigated perspectives of social justice activists who directly advocate for the elimination of Native-themed mascots, nicknames, and logos. Using Consensual Qualitative Research methodology, the research team analyzed transcripts of interviews conducted with eleven social justice activists to generate themes, categories, and domains within the data. Five domains emerged: (a) deleterious impact of Native-themed mascots, nicknames, and logos; (b) components of identity preservation among supporters; (c) reasons why some American Indians might support Native-themed mascots, nicknames, logos; (d) frontline advocacy efforts; and (e) coping strategies for advocates. Results provided insights into the sociopsychological processes which operate—among both non-Indians and Indians—to allow the misappropriation of American Indian culture, symbols, and imagery in sport to continue to exist in society. Findings can help counseling psychologists better understand the lived experience of social justice activists, while also highlighting ways that our field can support efforts to eliminate race-based mascots, nicknames, and logos

A user's guide to the GoldSim/BLT-MS integrated software package:a low-level radioactive waste disposal performance assessment model.

Sandia National Laboratories (Sandia), a U.S. Department of Energy National Laboratory, has over 30 years experience in the assessment of radioactive waste disposal and at the time of this publication is providing assistance internationally in a number of areas relevant to the safety assessment of radioactive waste disposal systems. In countries with small radioactive waste programs, international technology transfer program efforts are often hampered by small budgets, schedule constraints, and a lack of experienced personnel. In an effort to surmount these difficulties, Sandia has developed a system that utilizes a combination of commercially available software codes and existing legacy codes for probabilistic safety assessment modeling that facilitates the technology transfer and maximizes limited available funding. Numerous codes developed and endorsed by the United States Nuclear Regulatory Commission (NRC) and codes developed and maintained by United States Department of Energy are generally available to foreign countries after addressing import/export control and copyright requirements. From a programmatic view, it is easier to utilize existing codes than to develop new codes. From an economic perspective, it is not possible for most countries with small radioactive waste disposal programs to maintain complex software, which meets the rigors of both domestic regulatory requirements and international peer review. Therefore, revitalization of deterministic legacy codes, as well as an adaptation of contemporary deterministic codes, provides a credible and solid computational platform for constructing probabilistic safety assessment models. This document is a reference users guide for the GoldSim/BLT-MS integrated modeling software package developed as part of a cooperative technology transfer project between Sandia National Laboratories and the Institute of Nuclear Energy Research (INER) in Taiwan for the preliminary assessment of several candidate low-level waste repository sites. Breach, Leach, and Transport-Multiple Species (BLT-MS) is a U.S. NRC sponsored code which simulates release and transport of contaminants from a subsurface low-level waste disposal facility. GoldSim is commercially available probabilistic software package that has radionuclide transport capabilities. The following report guides a user through the steps necessary to use the integrated model and presents a successful application of the paradigm of renewing legacy codes for contemporary application

U.S. Nuclear Regulatory Commission Extremely Low Probability of Rupture pilot study : xLPR framework model user's guide.

Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owne

Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies

BACKGROUND: Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies, suggesting that they represent a promising new class of cancer biomarkers. However, previously reported methods for measuring miRNA expression consume large amounts of tissue, prohibiting high-throughput miRNA profiling from typically small clinical samples such as excision or core needle biopsies of breast or prostate cancer. Here we describe a novel combination of linear amplification and labeling of miRNA for highly sensitive expression microarray profiling requiring only picogram quantities of purified microRNA. RESULTS: Comparison of microarray and qRT-PCR measured miRNA levels from two different prostate cancer cell lines showed concordance between the two platforms (Pearson correlation R(2 )= 0.81); and extension of the amplification, labeling and microarray platform was successfully demonstrated using clinical core and excision biopsy samples from breast and prostate cancer patients. Unsupervised clustering analysis of the prostate biopsy microarrays separated advanced and metastatic prostate cancers from pooled normal prostatic samples and from a non-malignant precursor lesion. Unsupervised clustering of the breast cancer microarrays significantly distinguished ErbB2-positive/ER-negative, ErbB2-positive/ER-positive, and ErbB2-negative/ER-positive breast cancer phenotypes (Fisher exact test, p = 0.03); as well, supervised analysis of these microarray profiles identified distinct miRNA subsets distinguishing ErbB2-positive from ErbB2-negative and ER-positive from ER-negative breast cancers, independent of other clinically important parameters (patient age; tumor size, node status and proliferation index). CONCLUSION: In sum, these findings demonstrate that optimized high-throughput microRNA expression profiling offers novel biomarker identification from typically small clinical samples such as breast and prostate cancer biopsies

Go with the flow: A neuroscientific view on being fully engaged

Flow is a state of full task absorption, accompanied with a strong drive and low levels of self-referential thinking. Flow is likely when there is a match between a person's skills and the task challenge. Despite its relevance for human performance and the vast body of researc