MDH2 Life Span Raw Data

MDH2 Life Span Raw Dat

HexC Life Span Raw Data

HexC Life Span Raw Dat

Men Life Span Raw Data

Men Life Span Raw Dat

Gdh Life Span Raw Data

Gdh Life Span Raw Dat

Idh Life Span Raw Data

Idh Life Span Raw Dat

HexA Life Span Raw Data

HexA Life Span Raw Dat

Study Design.

<p>Study Design.</p

GWAS + Replication, Validation and Overall <i>P</i>-values for susceptibility loci identified from the Overall meta-analysis (P<2.5×10⁻⁵).

<p>SNPs are ordered by chromosome and position (NCBI Build 36.1, hg18) with the major/minor alleles (positive strand) and corresponding gene (underlined) or nearest annotated genes (+/−500 kb). For each phase of the study, GWAS + Replication, Validation and Overall (GWAS+Replication+T2DM+IRAS+IRASFS) analyses, the minor allele frequency (MAF) in controls, additive <i>P</i>-value and odds ratio (OR) with associated 95% confidence interval (CI) with respect to the minor allele is listed.</p

Clinical Characteristics of Study Samples.

<p>Values are presented as trait mean and standard deviation.</p

Genome-Wide Association Study Results.

<p>Results are adjusted for admixture using PC1 as a covariate in the analysis. <i>P</i>-values are shown under the additive model. The blue line at -log₁₀(<i>P</i>-value) = 3 represents an additive <i>P</i>-value = 0.001 and the red line at -log₁₀(<i>P</i>-value) = 5 represents a <i>P</i>-value = 1.0×10⁻⁵.</p