67 research outputs found
Magnetic-Field-Induced 4f-Octupole in CeB6 Probed by Resonant X-ray Diffraction
CeB6, a typical Gamma_8-quartet system, exhibits a mysterious
antiferroquadrupolar ordered phase in magnetic fields, which is considered as
originating from the T_{xyz}-type magnetic octupole moment induced by the
field. By resonant x-ray diffraction in magnetic fields, we have verified that
the T_{xyz}-type octupole is indeed induced in the 4f-orbital of Ce with a
propagation vector (1/2, 1/2, 1/2), thereby supporting the theory. We observed
an asymmetric field dependence of the intensity for an electric quadrupole (E2)
resonance when the field was reversed, and extracted a field dependence of the
octupole by utilizing the interference with an electric dipole (E1) resonance.
The result is in good agreement with that of the NMR-line splitting, which
reflects the transferred hyperfine field at the Boron nucleus from the
anisotropic spin distribution of Ce with an O_{xy}-type quadrupole. The
field-reversal method used in the present study opens up the possibility of
being widely applied to other multipole ordering systems such as NpO2,
Ce_{x}La_{1-x}B_{6}, SmRu_{4}P_{12}, and so on.Comment: 5 pages, 4 figures, submitte
Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus
Detailed investigation of extremely severe pathological conditions in ancient human skeletons is important as it could shed light on the breadth of potential interactions between humans and disease etiologies in the past. Here, we applied palaeoproteomics to investigate an ancient human skeletal individual with severe oral pathology, focusing our research on bacterial pathogenic factors and host defense response. This female skeleton, from the Okhotsk period (i.e., fifth to thirteenth century) of Northern Japan, poses relevant amounts of abnormal dental calculus deposition and exhibits oral dysfunction due to severe periodontal disease. A shotgun mass-spectrometry analysis identified 81 human proteins and 15 bacterial proteins from the calculus of the subject. We identified two pathogenic or bioinvasive proteins originating from two of the three "red complex" bacteria, the core species associated with severe periodontal disease in modern humans, as well as two additional bioinvasive proteins of periodontal-associated bacteria. Moreover, we discovered defense response system-associated human proteins, although their proportion was mostly similar to those reported in ancient and modern human individuals with lower calculus deposition. These results suggest that the bacterial etiology was similar and the host defense response was not necessarily more intense in ancient individuals with significant amounts of abnormal dental calculus deposition
Measurement of Na+ Activity in Endolymph in Guinea Pig Cochlea with a Sodium Sensitive Glass Microelectrode
Hobby engagement and risk of disabling dementia
BACKGROUND: The association between hobby engagement and risk of dementia reported from a short-term follow-up study for individuals aged ≥65 years may be liable to reverse causation. We examined the association between hobby engagement in age of 40-69 years and risk of dementia in a long-term follow-up study among Japanese including individuals in mid-life, when the majority of individuals have normal cognitive function. METHODS: A total of 22,377 individuals aged 40-69 years completed a self-administered questionnaire in 1993-1994. The participants answered whether they had hobbies according to the three following responses: having no hobbies, having a hobby, and having many hobbies. Follow-up for incident disabling dementia was conducted with long-term care insurance data from 2006 to 2016. RESULTS: During 11.0 years of median follow-up, 3,095 participants developed disabling dementia. Adjusting for the demographic, behavioral, and psychosocial factors, the multivariable hazard ratios (95% confidence intervals) of incident disabling dementia compared with "having no hobbies" were 0.82 (0.75-0.89) for "having a hobby" and 0.78 (0.67-0.91) for "having many hobbies". The inverse association was similarly observed in both middle (40-64 years) and older ages (65-69 years). For disabling dementia subtypes, hobby engagement was inversely associated with the risk of dementia without a history of stroke (probably non-vascular type dementia), but not with that of post-stroke dementia (probably vascular type dementia). CONCLUSIONS: Hobby engagement in both mid-life and late-life was associated with a lower risk of disabling dementia without a history of stroke
Antiferroquadrupole order and magnetic field induced octupole in CeB6
We have studied the antiferroquadrupole ordered phase of CeB6 in magnetic fields by resonant x-ray diffraction. By analyzing the significant change in the energy spectrum on reversing the field direction along [1̅ 1 0], we have deduced field dependencies of the antiferro components of magnetic dipole, electric quadrupole, and magnetic octupole moments which are simultaneously induced in the Ce 4f orbital with a propagation vector (1/2,1/2,1/2). The data treatments are based on theoretically calculated spectral functions. The existence of the field-induced octupole is also concluded for other field directions. We also show direct evidence for the formation of a linear-combination-type antiferroquadrupole order parameter in magnetic fields, which is expressed as 〈αOyz+βOzx+γOxy〉 and changes continuously with the field direction (α,β,γ). A possibility of observing the quadrupolar fluctuation is also pointed out
Prognostic Impact of Hypoxia-Inducible miRNA-210
Objective. The aim of this study was to investigate the prognostic value of MicroRNA-210 (miR-210) expression in patients with non-small-cell lung cancer (NSCLC). Methods. We examined the miR-210 expression of samples of 80 patients, who underwent surgical resection at Fukushima Medical University from 2004 to 2007, by using quantitative RT-PCR. The relationship between miR-210 expression and clinicopathological factors as well as histological subtype was statistically analyzed. Results. miR-210 expression showed an inverse correlation with disease-free and overall survival in patients with NSCLC. Significant correlations were found between miR-210 expression and lymph node metastasis, late disease stages, and poor prognosis in patients with adenocarcinoma. Multivariate Cox analysis indicated that miR-210 expression was an independent prognostic factor for disease-free survival in patients with adenocarcinoma. Conclusions. We showed that miR-210 may be a prognostic biomarker for patients with NSCLC, especially for those with lung adenocarcinoma
Development of a ubiquitous healthcare monitoring system combined with non-conscious and ambulatory physiological measurements and its application to medical care
The demand for ubiquitous healthcare monitoring has been increasingly raised for prevention of lifestyle-related diseases, acute life support or chronic therapies for inpatients and/or outpatients having chronic disorder and home medical care. From these view points, we developed a non-conscious healthcare monitoring system without any attachment of biological sensors and operations of devices, and an ambulatory postural changes and activities monitoring system. Furthermore in this study, in order to investigate those applicability to the ubiquitous healthcare monitoring, we have developed a new healthcare monitoring system combined with the non-conscious and the ambulatory measurements developed by us. In patients with chronic cardiovascular disease or stroke, the daily health conditions such as pulse, respiration, activities and so on, could be continuously measured in the hospital, the rehabilitation room and subject\u27s own home, using the present system. The results demonstrated that the system appears useful for the ubiquitous healthcare monitoring not only at medical facility, but also during daily living at home. © 2011 IEEE
Development of a ubiquitous healthcare monitoring system combined with non-conscious and ambulatory physiological measurements and its application to medical care.
The demand for ubiquitous healthcare monitoring has been increasingly raised for prevention of lifestyle-related diseases, acute life support or chronic therapies for inpatients and/or outpatients having chronic disorder and home medical care. From these view points, we developed a non-conscious healthcare monitoring system without any attachment of biological sensors and operations of devices, and an ambulatory postural changes and activities monitoring system. Furthermore in this study, in order to investigate those applicability to the ubiquitous healthcare monitoring, we have developed a new healthcare monitoring system combined with the non-conscious and the ambulatory measurements developed by us. In patients with chronic cardiovascular disease or stroke, the daily health conditions such as pulse, respiration, activities and so on, could be continuously measured in the hospital, the rehabilitation room and subject\u27s own home, using the present system. The results demonstrated that the system appears useful for the ubiquitous healthcare monitoring not only at medical facility, but also during daily living at home
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