Entanglement convertibility for infinite dimensional pure bipartite states

It is shown that the order property of pure bipartite states under SLOCC (stochastic local operations and classical communications) changes radically when dimensionality shifts from finite to infinite. In contrast to finite dimensional systems where there is no pure incomparable state, the existence of infinitely many mutually SLOCC incomparable states is shown for infinite dimensional systems even under the bounded energy and finite information exchange condition. These results show that the effect of the infinite dimensionality of Hilbert space, the ``infinite workspace'' property, remains even in physically relevant infinite dimensional systems

Flap Reconstruction for Esophageal Perforation Following Anterior Cervical Plate Fixation

Anterior cervical plate fixation is a common surgical treatment for cervical spine trauma, disc herniation, or cervical spondylosis. Esophageal perforation following anterior cervical plate fixation is a rare but serious complication. Management of esophageal perforation is controversial; however, we suggest treating most cases surgically because this condition is slow to heal and often fatal. We managed 2 cases of esophageal perforation following anterior cervical plate fixation by flap reconstruction with the pectoralis major muscle in one case and a jejunal free flap in the other. Here, we report our experience and review the surgical indications

Differences in Adverse Drug Events Among Pediatric Patients With and Without Cancer: Sub-Analysis of a Retrospective Cohort Study

Objectives: This study investigated the differences in the incidence and severity of adverse drug events (ADEs) in pediatric patients with and without cancer. Methods: We used data from the Japan Adverse Drug Events Study for pediatrics, a cohort study enrolling pediatric inpatients at two tertiary care teaching hospitals in Japan. ADEs were identified by on-site review of all medical charts, incident reports, and prescription queries by pharmacists. Two independent physicians reviewed all potential ADEs and classified ADEs in terms of severity and class of causative medication. We compared the incidence and characteristics of ADEs between pediatric cancer patients and non-cancer patients. Results: We enrolled 1189 patients during the study period, 27 with cancer and 1162 without cancer. We identified 480 ADEs in 234 patients (20%): 191 ADEs among 21 cancer patients and 289 ADEs among 213 non-cancer patients (7.1 per patient vs. 0.25 per patient, respectively; p < 0.0001). The most common medications associated with ADEs in cancer patients were antitumor agents; in contrast, medications associated with fatal or life-threatening ADEs in cancer patients were most often sedatives (25%) and blood products (25%). Medications associated with fatal or life-threatening ADEs among non-cancer patients were most often sedatives (15%). The percentages of fatal or life-threatening ADEs in cancer patients and non-cancer patients were 2.1 and 4.5%, respectively. Conclusions: Pediatric patients with cancer have a higher risk for ADEs. Although the overall severity was similar between patients with and without cancer, the most common classes of causative medication and medications associated with a higher rate of severe ADEs differed. Application of this information may help minimize the impact of ADEs in pediatric patients

Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer

L-type amino acid transporter 1 (LAT1), also referred to as SLC7A5, is believed to regulate tumor metabolism and be associated with tumor proliferation. In invasive breast cancer, we clinicopathologically investigated the utility of LAT1 expression. LAT1 expression was evaluated via immunohistochemistry analyses in 250 breast cancer patients undergoing long-term follow-up. We assessed the relationships between LAT1 expression and patient outcomes and clinicopathological factors. Breast cancer-specific survival stratified by LAT1 expression was assessed. Human epidermal growth factor receptor 2 (HER2)-positive patients with metastasis received trastuzumab therapy. The density of tumor-infiltrating lymphocytes (TILs) was evaluated according to the International Working Group guidelines. In the current study, high LAT1 expression was significantly correlated with estrogen receptor (ER) negativity, progesterone receptor negativity, high histological grade, increased TILs, and programmed death ligand 1 positivity. Among the ER-positive and HER2-negative patients, high LAT1 was an independent indicator of poor outcomes (hazard ratio (HR) = 2.97; 95% confidence interval (CI), 1.16–7.62; p = 0.023). Moreover, high LAT1 expression was an independent poor prognostic factor in luminal B-like breast cancer with aggressive features (HR = 3.39; 95% CI 1.35–8.52; p = 0.0094). In conclusion, high LAT1 expression could be used to identify a subgroup of invasive breast cancer characterized by aggressive behavior and high tumor immunoreaction. Our findings suggest that LAT1 might be a candidate therapeutic target for breast cancer patients, particularly those with luminal B-like type breast cancer

KMT-2021-BLG-1150Lb: Microlensing planet detected through a densely covered planetary-caustic signal

Recently, there have been reports of various types of degeneracies in the interpretation of planetary signals induced by planetary caustics. In this work, we check whether such degeneracies persist in the case of well-covered signals by analyzing the lensing event KMT-2021-BLG-1150, for which the light curve exhibits a densely and continuously covered short-term anomaly. In order to identify degenerate solutions, we thoroughly investigate the parameter space by conducting dense grid searches for the lensing parameters. We then check the severity of the degeneracy among the identified solutions. We identify a pair of planetary solutions resulting from the well-known inner-outer degeneracy, and find that interpreting the anomaly is not subject to any degeneracy other than the inner-outer degeneracy. The measured parameters of the planet separation (normalized to the Einstein radius) and mass ratio between the lens components are $(s, q)_{\rm in}\sim (1.297, 1.10\times 10^{-3})$ for the inner solution and $(s, q)_{\rm out}\sim (1.242, 1.15\times 10^{-3})$ for the outer solution. According to a Bayesian estimation, the lens is a planetary system consisting of a planet with a mass $M_{\rm p}=0.88^{+0.38}_{-0.36}~M_{\rm J}$ and its host with a mass $M_{\rm h}=0.73^{+0.32}_{-0.30}~M_\odot$ lying toward the Galactic center at a distance $D_{\rm L} =3.8^{+1.3}_{-1.2}$~kpc. By conducting analyses using mock data sets prepared to mimic those obtained with data gaps and under various observational cadences, it is found that gaps in data can result in various degenerate solutions, while the observational cadence does not pose a serious degeneracy problem as long as the anomaly feature can be delineated.Comment: 9 pages, 8 figure

KMT-2022-BLG-0440Lb: A New q<10−4q < 10^{-4} Microlensing Planet with the Central-Resonant Caustic Degeneracy Broken

We present the observations and analysis of a high-magnification microlensing planetary event, KMT-2022-BLG-0440, for which the weak and short-lived planetary signal was covered by both the KMTNet survey and follow-up observations. The binary-lens models with a central caustic provide the best fits, with a planet/host mass ratio, $q = 0.75$--$1.00 \times 10^{-4}$ at $1\sigma$. The binary-lens models with a resonant caustic and a brown-dwarf mass ratio are both excluded by $\Delta\chi^2 > 70$. The binary-source model can fit the anomaly well but is rejected by the ``color argument'' on the second source. From Bayesian analyses, it is estimated that the host star is likely a K or M dwarf located in the Galactic disk, the planet probably has a Neptune-mass, and the projected planet-host separation is $1.9^{+0.6}_{-0.7}$ or $4.6^{+1.4}_{-1.7}$ au, subject to the close/wide degeneracy. This is the third $q < 10^{-4}$ planet from a high-magnification planetary signal ($A \gtrsim 65$). Together with another such planet, KMT-2021-BLG-0171Lb, the ongoing follow-up program for the KMTNet high-magnification events has demonstrated its ability in detecting high-magnification planetary signals for $q < 10^{-4}$ planets, which are challenging for the current microlensing surveys.Comment: MNRAS accepte

KMT-2023-BLG-1431Lb: A New q<10−4q < 10^{-4} Microlensing Planet from a Subtle Signature

The current studies of microlensing planets are limited by small number statistics. Follow-up observations of high-magnification microlensing events can efficiently form a statistical planetary sample. Since 2020, the Korea Microlensing Telescope Network (KMTNet) and the Las Cumbres Observatory (LCO) global network have been conducting a follow-up program for high-magnification KMTNet events. Here, we report the detection and analysis of a microlensing planetary event, KMT-2023-BLG-1431, for which the subtle (0.05 magnitude) and short-lived (5 hours) planetary signature was characterized by the follow-up from KMTNet and LCO. A binary-lens single-source (2L1S) analysis reveals a planet/host mass ratio of $q = (0.72 \pm 0.07) \times 10^{-4}$, and the single-lens binary-source (1L2S) model is excluded by $\Delta\chi^2 = 80$. A Bayesian analysis using a Galactic model yields estimates of the host star mass of $M_{\rm host} = 0.57^{+0.33}_{-0.29}~M_\odot$, the planetary mass of $M_{\rm planet} = 13.5_{-6.8}^{+8.1}~M_{\oplus}$, and the lens distance of $D_{\rm L} = 6.9_{-1.7}^{+0.8}$ kpc. The projected planet-host separation of $a_\perp = 2.3_{-0.5}^{+0.5}$ au or $a_\perp = 3.2_{-0.8}^{+0.7}$, subject to the close/wide degeneracy. We also find that without the follow-up data, the survey-only data cannot break the degeneracy of central/resonant caustics and the degeneracy of 2L1S/1L2S models, showing the importance of follow-up observations for current microlensing surveys.Comment: PASP submitted. arXiv admin note: text overlap with arXiv:2301.0677