A five-year review of quality of reporting of research using clinician surveys in high-ranked dermatology journals

Surveys of clinicians play a pivotal role in dermatology research, including to determine expert opinion, identify areas of uncertainty in clinical practice, define research priorities, investigate feasibility and explore areas of clinical equipoise. Despite the commonality of research involving surveys distributed to dermatologists, we previously identified the issue of poor‐quality survey design and lack of sufficient validation prior to distribution. Furthermore, a review of postal surveys of healthcare professionals from 1996 to 2005 has shown declining response rates, introducing potential non‐responder bias. To support stronger methodological quality and reporting of clinician survey, we developed a checklist for authors, based on our experience and published literature

Extraction, optical properties, and aging studies of natural pigments of various flower plants

In this paper, we reported the extraction process of five different flowering plants utilizing different dye extraction methods and solvents (ethanol and water) to choose the best dye removal process. The FTIR spectra revealed the presence of several clear functional groups for all five natural dyes. The analytical studies such as UV spectroscopy, column chromatography, and vacuum evaporation were performed to isolate the dyes from their solutions. The UV-Vis studies on the pigments of flower extracts indicated broad absorption peaks in the visible region including clear bandgaps. Among the studied pigments, Alternanthera ficoidea showed the lowest direct bandgap of 1.69 eV and an Urbach energy value of 6.33 meV. The dye extraction yield rate improvement was extended from 11.7 to 24.7% (water solvent) and 11.3–32.4% (ethanol solvent). Throughout the studies, it was observed that ethanol produced a better extraction for organic dyes than water as a solvent. Aging studies revealed that all the dyes at the room temperature showed better stability with minor changes in the observed optical parameters in oxygen-rich conditions; however, these parameters have shown significant variations at a 60 °C temperature

Therapeutic approaches to pediatric pseudotumor cerebri: new insights from literature data

The pseudotumor cerebri syndrome (PTCS), also known as idiopathic intracranial hypertension (IIH), is characterized by signs and symptoms of increased intracranial pressure such as headache and cranial nerve palsies, in the absence of any space-occupying mass. This condition commonly affects overweight women of childbearing age, even if it is also frequent in men and children. Children with PTCS may present with atypical signs and symptoms, with a different prognosis compared to adults. However, the treatment is the same for both children and adults, even if there are no strict treatment guidelines in regards. All treatment strategies in children are based on retrospective studies and none has been evaluated in prospective or randomized controlled trial studies. This review focuses on literature data on PTCS treatment in children

A 10-year Review of Surgical Management of Dermatofibrosarcoma Protuberans

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Standard treatment in the United Kingdom (UK) is either surgical wide local excision (WLE) or Mohs micrographic surgery (MMS). It is unclear which approach has the lower recurrence rate.Objectives: We undertook a retrospective comparative review of DFSP surgical management in the UK National Health Service (NHS) in order to define:1) current surgical practice for primary and recurrent DFSP2) local recurrence rates for primary DFSP3) survival outcomes for DFSP.Methods: Retrospective clinical case-note review of patients with histologically-confirmed DFSP (January 2004–2014) who have undergone surgical treatment.Results: Surgical management of 483 primary and 64 recurrent DFSP in 11 plastic surgery and 15 dermatology departments was analysed. Almost 75% of primary DFSP (n=362) were treated with WLE and 20.1% (n=97) with MMS. For recurrent DFSP, 68.7% (n=44) and 23.4% (n=15) underwent WLE and MMS, respectively. Recurrent primary DFSP occurred in 6 patients after WLE and none after MMS. Median follow-up was 4.8 years [IQR 3.5, 5.8] with 8 reported deaths during the follow-up analysis period; one confirmed to be DFSP-related.Conclusions: WLE was the commonest surgical modality used to treat DFSP across the UK. The local recurrence rate was very low, occurring only after WLE. Although a prospective RCT may provide more definitive outcomes, in the absence of a clearly superior surgical modality, treatment decisions should be based on patient preference, clinical expertise and cost

Ratio of shear viscosity to entropy density in multifragmentation of Au + Au

The ratio of the shear viscosity ($\eta$) to entropy density ($s$) for the intermediate energy heavy-ion collisions has been calculated by using the Green-Kubo method in the framework of the quantum molecular dynamics model. The theoretical curve of $\eta/s$ as a function of the incident energy for the head-on Au+Au collisions displays that a minimum region of $\eta/s$ has been approached at higher incident energies, where the minimum $\eta/s$ value is about 7 times Kovtun-Son- Starinets (KSS) bound (1/4$\pi$). We argue that the onset of minimum $\eta/s$ region at higher incident energies corresponds to the nuclear liquid gas phase transition in nuclear multifragmentation.Comment: 6 pages, 8 figure

Randomized Control Trials and Qualitative Evaluations of a Multifaceted Programme for Women in Extreme Poverty: Empirical Findings and Methodological Reflections

This paper sets out to synthesize key lessons from studies using alternative methodologies to impact assessment. Drawing on Sen’s capability approach as a conceptual framework, it analyses two pairs of impact assessments which were carried out in West Bengal and Sindh around the same time and within close proximity to each other. Each pair consisted of a randomized control trial and a qualitative assessment of attempts to pilot BRAC’s approach to transferring assets to women in extreme poverty. The paper reports on the findings of these studies, their strategies for establishing their claims about causality and the information base they drew on to establish these claims. It finds that not only did the RCTs fail to meet their own criteria for establishing causality, but they also provided very limited explanation for the patterns of outcomes observed. Such information formed the substance of the qualitative studies. The paper concludes that greater use of mixed methods could help to offset some of limitations of RCTs and to place their findings on much firmer ground

Artificial intelligence and machine learning algorithms for early detection of skin cancer in community and primary care settings : a systematic review

Acknowledgments This systematic review was funded by the National Institute for Health Research Policy Research Programme, conducted through the Policy Research Unit in Cancer Awareness, Screening, and Early Diagnosis (PR-PRU-1217–21601). The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, the NIHR or the Department of Health and Social Care. The first author (OTJ) was also supported by the CanTest Collaborative funded by Cancer Research UK (C8640/A23385), of which FMW is Director, JE is an Associate Director, and NC is Research Fellow. During protocol development, this Review benefited from the advice of an international expert panel from the CanTest collaborative, including Willie Hamilton (University of Exeter, Exeter, UK), Greg Rubin (University of Newcastle, Newcastle, UK), Hardeep Singh (Baylor College of Medicine, Houston, TX, USA), and Niek de Wit (University Medical Center Utrecht, Utrecht, Netherlands). The research was also supported by a Cancer Research UK Cambridge Centre Clinical Research Fellowship for OTJ, and a National Health and Medical Research Council Investigator Fellowship (APP1195302) for JE. The funding sources had no role in the study design, data collection, data analysis, data interpretation, writing of the report, or in the decision to submit for publication. The authors would like to thank Isla Kuhn (Reader Services Librarian, University of Cambridge Medical Library, Cambridge, UK) for her help in developing the search strategy. We also thank Smiji Saji, who assisted with the early stages of the Review, Haruyuki Yanaoka, who assisted with the translation and assessment of papers that were written in Korean, and Steve Morris who assisted with the analysis of the data.Peer reviewedPublisher PD

Recent Developments of Flexible CdTe Solar Cells on Metallic Substrates: Issues and Prospects

This study investigates the key issues in the fabrication of CdTe solar cells on metallic substrates, their trends, and characteristics as well as effects on solar cell performance. Previous research works are reviewed while the successes, potentials, and problems of such technology are highlighted. Flexible solar cells offer several advantages in terms of production, cost, and application over glass-based types. Of all the metals studied as substrates for CdTe solar cells, molybdenum appears the most favorable candidate, while close spaced sublimation (CSS), electrodeposition (ED), magnetic sputtering (MS), and high vacuum thermal evaporation (HVE) have been found to be most common deposition technologies used for CdTe on metal foils. The advantages of these techniques include large grain size (CSS), ease of constituent control (ED), high material incorporation (MS), and low temperature process (MS, HVE, ED). These invert-structured thin film CdTe solar cells, like their superstrate counterparts, suffer from problems of poor ohmic contact at the back electrode. Thus similar strategies are applied to minimize this problem. Despite the challenges faced by flexible structures, efficiencies of up to 13.8% and 7.8% have been achieved in superstrate and substrate cell, respectively. Based on these analyses, new strategies have been proposed for obtaining cheaper, more efficient, and viable flexible CdTe solar cells of the future