17,584 research outputs found
Appropriate technology for Aboriginal Enterprise Development
RADG has been developing appropriate health technology for use in remote communities in Australia. The greatest need for these technologies has been in Aboriginal communities. In developing appropriate technical artifacts, RADG has confronted two problems. Firstly we require good contact with remote communities for consultation and feedback. Secondly, part of making artifacts appropriate for under-developed countries or regions, is the need to include employment and self-determination as part of the benefits of a technology
The Complex Links Between Governance and Biodiversity
We argue that two problems weaken the claims of those who link corruption and the exploitation of natural resources. The first is conceptual. Studies that use national level indicators of corruption fail to note that corruption comes in many forms, at multiple levels, and may or may not affect resource use. Without a clear causal model of the mechanism by which corruption affects resources, one should treat with caution any estimated relationship between corruption and the state of natural resources. The second problem is methodological: Simple models linking corruption measures and natural resource use typically do not account for other important causes and control variables pivotal to the relationship between humans and natural resources. By way of illustration of these two general concerns, we demonstrate that the findings of a well known recent study that posits a link between corruption and decreases in forests, elephants, and rhinoceros are fragile to simple conceptual and methodological refinements
Unconstrained Scene Text and Video Text Recognition for Arabic Script
Building robust recognizers for Arabic has always been challenging. We
demonstrate the effectiveness of an end-to-end trainable CNN-RNN hybrid
architecture in recognizing Arabic text in videos and natural scenes. We
outperform previous state-of-the-art on two publicly available video text
datasets - ALIF and ACTIV. For the scene text recognition task, we introduce a
new Arabic scene text dataset and establish baseline results. For scripts like
Arabic, a major challenge in developing robust recognizers is the lack of large
quantity of annotated data. We overcome this by synthesising millions of Arabic
text images from a large vocabulary of Arabic words and phrases. Our
implementation is built on top of the model introduced here [37] which is
proven quite effective for English scene text recognition. The model follows a
segmentation-free, sequence to sequence transcription approach. The network
transcribes a sequence of convolutional features from the input image to a
sequence of target labels. This does away with the need for segmenting input
image into constituent characters/glyphs, which is often difficult for Arabic
script. Further, the ability of RNNs to model contextual dependencies yields
superior recognition results.Comment: 5 page
Biological functions of CDK5 and potential CDK5 targeted clinical treatments.
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit. For most CDKs, activation by a cyclin occurs through association and phosphorylation of the CDK\u27s T-loop. CDK5 is unusual because it is not typically activated upon binding with a cyclin and does not require T-loop phosphorylation for activation, even though it has high amino acid sequence homology with other CDKs. While it was previously thought that CDK5 only interacted with p35 or p39 and their cleaved counterparts, Recent evidence suggests that CDK5 can interact with certain cylins, amongst other proteins, which modulate CDK5 activity levels. This review discusses recent findings of molecular interactions that regulate CDK5 activity and CDK5 associated pathways that are implicated in various diseases. Also covered herein is the growing body of evidence for CDK5 in contributing to the onset and progression of tumorigenesis
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