Instabilities in a Mean-field dynamics of Asymmetric Nuclear Matter

We discuss the features of instabilities in asymmetric nuclear matter, in particular the relation between the nature of fluctuations, the types of instabilities and the properties of the interaction. We show a chemical instability appears as an instability against isoscalar-like fluctuations. Then starting from phenomenological hadronic field theory (QHD), including exchange terms, we discuss the symmetry energy and the relation to the dynamical response inside the spinodal region.Comment: 8 pages, 5 Postscript figures, talk at Cortona 2000 Conference, Oct. 17 - Oct. 20, Italy, World Scientific (in press

Influence of vector interactions on the hadron-quark/gluon phase transition

The hadron-quark/gluon phase transition is studied in the two-phase model. As a further study of our previous work, both the isoscalar and isovector vector interactions are included in the Polyakov loop modified Nambu--Jona-Lasinio model (PNJL) for the quark phase. The relevance of the exchange (Fock) terms is stressed and suitably accounted for. The calculation shows that the isovector vector interaction delays the phase transition to higher densities and the range of the mixed phase correspondingly shrinks. Meanwhile the asymmetry parameter of quark matter in the mixed phase decreases with the strengthening of this interaction channel. This leads to some possible observation signals being weakened, although still present. We show that these can be rather general effects of a repulsion in the quark phase due to the symmetry energy. This is also confirmed by a simpler calculation with the MIT--Bag model. However, the asymmetry parameter of quark matter is slightly enhanced with the inclusion of the isoscalar vector interaction, but the phase transition will be moved to higher densities. The largest uncertainty on the phase transition lies in the undetermined coupling constants of the vector interactions. In this respect new data on the mixed phase obtained from Heavy Ion Collisions at Intermediate Energies appear very important.Comment: submitted to Phys. Rev.

Pharmacological management of COVID-19 patients with ARDS (CARDS): A narrative review

Coronavirus disease 2019 (COVID-19) is highly infectious. It has been highlighted that if not expertly and individually managed with consideration of the vasocentric features, a COVID-19 patient with an acute respiratory distress syndrome (CARDS) may eventually develop multiorgan failure. Unfortunately, there is still no definite drug for CARDS that is capable of reducing either short-term or long-term mortality and no specific treatments for COVID-19 exist right now. In this narrative review, based on a selective literature search in EMBASE, MEDLINE, Scopus, The Cochrane Library, Web of Science, and Google Scholar and ClinicalTrials.gov, we have examined the emerging evidence on the possible treatment of CARDS. Although numerous pharmacologic therapies to improve clinical outcomes in CARDS have been studied also in clinical trials, none have shown efficacy and there is great uncertainty about their effectiveness. There is still no recommendation for the therapeutic use of any specific agent to treat CARDS because no drugs are validated to have significant efficacy in clinical treatment of COVID-19 patients in large-scale trials. However, there exist a number of drugs that may be useful at least in some patients. The real challenge now is to link the right patient to the right treatment

Active Rules for Runtime Adaptivity Management

The trend over the last years clearly shows that modern Web development is evolving from traditional, HTML-based Web sites to fullfledged, complex Web applications, also equipped with active and/or adaptive application features. While this evolution unavoidably implies higher development costs and times, such implications are contrasted by the dynamics of the modern Web, which demands for even faster application development and evolution cycles. In this paper we address the above problem by focusing on the case of adaptive Web applications. We illustrate an ECA rule-based approach, intended to facilitate the management and evolution of adaptive application features. For this purpose, we stress the importance of decoupling the active logic (i.e. the adaptivity rules) from the execution of the actual application by means of a decoupled rule engine that is able to capture events and to autonomously enact adaptivity actions

Relativistic Approach to Superfluidity in Nuclear Matter

Pairing correlations in symmetric nuclear matter are studied within a relativistic mean-field approximation based on a field theory of nucleons coupled to neutral ($\sigma$ and $\omega$) and to charged ($\varrho$) mesons. The Hartree-Fock and the pairing fields are calculated in a self-consistent way. The energy gap is the result of a strong cancellation between the scalar and vector components of the pairing field. We find that the pair amplitude vanishes beyond a certain value of momentum of the paired nucleons. This fact determines an effective cutoff in the gap equation. The value of this cutoff gives an energy gap in agreement with the estimates of non relativistic calculations.Comment: 21 pages, REVTEX, 8 ps-figures, to appear in Phys.Rev.C. e-mail: [email protected]

Cholinergic suppression: A postsynaptic mechanism of long-term associative learning

Food avoidance learning in the mollusc Pleurobranchaea entails reduction in the responsiveness of key brain interneurons in the feeding neural circuitry, the paracerebral feeding command interneurons (PCNs), to the neurotransmitter acetylcholine (AcCho). Food stimuli applied to the oral veil of an untrained animal depolarize the PCNs and induce the feeding motor program (FMP). Atropine (a muscarinic cholinergic antagonist) reversibly blocks the food-induced depolarization of the PCNs, implicating AcCho as the neurotransmitter mediating food detection. AcCho applied directly to PCN somata depolarizes them, indicating that the PCN soma membrane contains AcCho receptors and induces the FMP in the isolated central nervous system preparation. The AcCho response of the PCNs is mediated by muscariniclike receptors, since comparable depolarization is induced by muscarinic agonists (acetyl-ß -methylcholine, oxotremorine, pilocarpine), but not nicotine, and blocked by muscarinic antagonists (atropine, trifluoperazine). The nicotinic antagonist hexamethonium, however, blocked the AcCho response in four of six cases. When specimens are trained to suppress feeding behavior using a conventional food-avoidance learning paradigm (conditionally paired food and shock), AcCho applied to PCNs in the same concentration as in untrained animals causes little or no depolarization and does not initiate the FMP. Increasing the concentration of AcCho 10-100 times, however, induces weak PCN depolarization in trained specimens, indicating that learning diminishes but does not fully abolish AcCho responsiveness of the PCNs. This study proposes a cellular mechanism of long-term associative learning -- namely, postsynaptic modulation of neurotransmitter responsiveness in central neurons that could apply also to mammalian species

Salmeterol and formoterol in partially reversible severe chronic obstructive pulmonary disease: a dose-response study

AbstractWhen testing the response to β2-agonist drugs in severe chronic obstructive pulmonary disease (COPD), a dose-response assessment should be undertaken. This study compares the time course of inhaled salmeterol (25, 50 and 75 μg) and formoterol (12, 24 and 36 μg) at different doses in a group of 12 patients with partially reversible, but severe COPD (FEV1 of 12–32% of predicted values after β2-agonist drugs had been withheld for 24 h). All doses of salmeterol and formoterol induced a significant (P<0·01) spirometric improvement over the 12-h monitoring period, when compared to the spirometric improvement after placebo, but while formoterol induced a dose-dependent increase of the FVC, FEV1 and FEF50, this was not the case for salmeterol. In fact, 75 μg salmeterol did not produce a further improvement of these parameters. Mean peak bronchodilation, expressed as the increase in FEV1 over baseline values, occurred 2 h after inhalation of the three doses of salmeterol, and 1 h after inhalation of the three doses of formoterol. A comparison of 50 μg salmeterol with 12 μg or 24 μg formoterol (clinically recommended doses), showed that improvement of FEV1 after salmeterol was statistically (P<0·05) higher than that after the two doses of formoterol, although the mean peak bronchodilations were similar. This was because salmeterol has a longer duration of action than formoterol. These data demonstrate that salmeterol is equally effective as, but longer-acting than, formoterol at clinically recommended doses in patients suffering from COPD, with severe airway obstruction. Moreover, these data suggest that 50 μg is the best dosage for salmeterol in these patients