4,065 research outputs found

    Immigració a Catalunya als anys noranta, quelcom de nou?

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    This brief article pretends to answer the following question: Which are the implications of foreign immigration in Catalonia? In order to do so, it deals with a supposed specificity of an immigration model, different to other autonomous regions in Spain, and even in the framework of Southern Europe. In an introductory style, various proposals for integration policies are examined.Este breve artículo pretende responder a la pregunta sobre qué implica la inmigración extranjera en Cataluña, considerando si existe un modelo de inmigración diferente al de otras comunidades autonómas españolas e incluso viendo su especificidad en un modelo del Sur de Europa. A modo introductorio analiza las propuestas elaboradas respecto a una política de integración social

    Towards Greener and More Cost-efficient Biosynthesis of Pharmaceuticals and Fragrance Molecules

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    Enzymes are natural catalysts which are gaining momentum in chemical synthesis due to their exquisiteselectivity and their biodegradability. However, the cost-efficiency and the sustainability of the overall biocatalytic process must be enhanced to unlock completely the potential of enzymes for industrial applications. To reach this goal, enzyme immobilization and the integration into continuous flow reactors have been the cornerstone of our research. We showed key examples of the advantages of those tools for the biosynthesis of antivirals, anticancer drugs, and valuable fragrance molecules. By combining new strategies to immobilize biocatalysts, innovative bioengineering approaches, and process development, the performance of the reactions could be boosted up to 100-fold

    Noise characterization of an atomic magnetometer at sub-millihertz frequencies

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    Noise measurements have been carried out in the LISA bandwidth (0.1 mHz to 100 mHz) to characterize an all-optical atomic magnetometer based on nonlinear magneto-optical rotation. This was done in order to assess if the technology can be used for space missions with demanding low-frequency requirements like the LISA concept. Magnetometry for low-frequency applications is usually limited by 1/f1/f noise and thermal drifts, which become the dominant contributions at sub-millihertz frequencies. Magnetic field measurements with atomic magnetometers are not immune to low-frequency fluctuations and significant excess noise may arise due to external elements, such as temperature fluctuations or intrinsic noise in the electronics. In addition, low-frequency drifts in the applied magnetic field have been identified in order to distinguish their noise contribution from that of the sensor. We have found the technology suitable for LISA in terms of sensitivity, although further work must be done to characterize the low-frequency noise in a miniaturized setup suitable for space missions.Comment: 11 pages, 12 figure

    Lagged and instantaneous dynamical influences related to brain structural connectivity

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    Contemporary neuroimaging methods can shed light on the basis of human neural and cognitive specializations, with important implications for neuroscience and medicine. Different MRI acquisitions provide different brain networks at the macroscale; whilst diffusion-weighted MRI (dMRI) provides a structural connectivity (SC) coincident with the bundles of parallel fibers between brain areas, functional MRI (fMRI) accounts for the variations in the blood-oxygenation-level-dependent T2* signal, providing functional connectivity (FC).Understanding the precise relation between FC and SC, that is, between brain dynamics and structure, is still a challenge for neuroscience. To investigate this problem, we acquired data at rest and built the corresponding SC (with matrix elements corresponding to the fiber number between brain areas) to be compared with FC connectivity matrices obtained by 3 different methods: directed dependencies by an exploratory version of structural equation modeling (eSEM), linear correlations (C) and partial correlations (PC). We also considered the possibility of using lagged correlations in time series; so, we compared a lagged version of eSEM and Granger causality (GC). Our results were two-fold: firstly, eSEM performance in correlating with SC was comparable to those obtained from C and PC, but eSEM (not C nor PC) provides information about directionality of the functional interactions. Second, interactions on a time scale much smaller than the sampling time, captured by instantaneous connectivity methods, are much more related to SC than slow directed influences captured by the lagged analysis. Indeed the performance in correlating with SC was much worse for GC and for the lagged version of eSEM. We expect these results to supply further insights to the interplay between SC and functional patterns, an important issue in the study of brain physiology and function.Comment: Accepted and published in Frontiers in Psychology in its current form. 27 pages, 1 table, 5 figures, 2 suppl. figure

    Constructing networks of defects with scalar fields

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    We propose a new way to build networks of defects. The idea takes advantage of the deformation procedure recently employed to describe defect structures, which we use to construct networks, spread from small rudimentary networks that appear in simple models of scalar fields.Comment: 5 pages, 4 figures, version with new title, motivations and references, to appear in PL

    Perspectives on flow biocatalysis: the engine propelling enzymatic reactions

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    Flow biocatalysis has emerged as an empowering tool to boost the potential of enzymatic reactions towards more automatized, sustainable, and generally efficient synthetic processes. In the last fifteen years, the increasing number of biocatalytic transformations carried out in continuous flow exemplified the benefits that this technology can bring to incorporate biocatalysis into industrial operations. This perspective aims to capture in a nutshell the available methodologies for flow biocatalysis as well as to discuss the current limitations and the future directions in this field

    A paradox in the approximation of Dirichlet control problems in curved domains

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    In this paper, we study the approximation of a Dirichlet control problem governed by an elliptic equation defined on a curved domain Ω. To solve this problem numerically, it is usually necessary to approximate Ω by a (typically polygonal) new domain Ωh. The difference between the solutions of both infinite-dimensional control problems, one formulated in Ω and the second in Ωh, was studied in [E. Casas and J. Sokolowski, SIAM J. Control Optim., 48 (2010), pp. 3746–3780], where an error of order O(h) was proved. In [K. Deckelnick, A. G¨unther, and M. Hinze, SIAM J. Control Optim., 48 (2009), pp. 2798–2819], the numerical approximation of the problem defined in Ω was considered. The authors used a finite element method such that Ωh was the polygon formed by the union of all triangles of the mesh of parameter h. They proved an error of order O(h3/2) for the difference between continuous and discrete optimal controls. Here we show that the estimate obtained in [E. Casas and J. Sokolowski, SIAM J. Control Optim., 48 (2010), pp. 3746–3780] cannot be improved, which leads to the paradox that the numerical solution is a better approximation of the optimal control than the exact one obtained just by changing the domain from Ω to Ωh
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