Are the Ogle Microlenses in the Galactic Bar?

The analysis of the first two years of OGLE data revealed 9 microlensing events of the galactic bulge stars, with the characteristic time scales in the range $8.6 < t_0 < 62$ days, where $t_0 = R_E / V$. The optical depth to microlensing is larger than $( 3.3 \pm 1.2 ) \times 10^{-6}$, in excess of current theoretical estimates, indicating a much higher efficiency for microlensing by either bulge or disk lenses. We argue that the lenses are likely to be ordinary stars in the galactic bar, which has its long axis elongated towards us. A relation between $t_0$ and the lens masses remains unknown until a quantitative model of bar microlensing becomes available. At this time we have no evidence that the OGLE events are related to dark matter. The geometry of lens distribution can be determined observationally when the microlensing rate is measured over a larger range of galactic longitudes, like $-10^o < l < +10^o$, and the relative proper motions of the galactic bulge (bar) stars are measured with the HST.Comment: 10 pages, 2 figures, revised version accepted for the publication in ApJL, uses AAS LaTeX aaspp.sty macro, PostScript figures and PostScript version of the paper available through anonymous ftp from astro.princeton.edu, directory stanek/tau, or on reques

DIRECT Distances to Nearby Galaxies Using Detached Eclipsing Binaries and Cepheids. III. Variables in the Field M31C

We undertook a long term project, DIRECT, to obtain the direct distances to two important galaxies in the cosmological distance ladder -- M31 and M33 -- using detached eclipsing binaries (DEBs) and Cepheids. While rare and difficult to detect, DEBs provide us with the potential to determine these distances with an accuracy better than 5%. The extensive photometry obtained in order to detect DEBs provides us with good light curves for the Cepheid variables. These are essential to the parallel project to derive direct Baade-Wesselink distances to Cepheids in M31 and M33. For both Cepheids and eclipsing binaries, the distance estimates will be free of any intermediate steps. As a first step in the DIRECT project, between September 1996 and October 1997 we obtained 95 full/partial nights on the F. L. Whipple Observatory 1.2 m telescope and 36 full nights on the Michigan-Dartmouth-MIT 1.3 m telescope to search for DEBs and new Cepheids in the M31 and M33 galaxies. In this paper, third in the series, we present the catalog of variable stars, most of them newly detected, found in the field M31C [(alpha,delta)=(11.10, 41.42) deg, J2000.0}]. We have found 115 variable stars: 12 eclipsing binaries, 35 Cepheids and 68 other periodic, possible long period or non-periodic variables. The catalog of variables, as well as their photometry and finding charts, is available via anonymous ftp and the World Wide Web. The complete set of the CCD frames is available upon request.Comment: submitted to the Astronomical Journal, 39 pages, 27 figures; paper and data available at ftp://cfa-ftp.harvard.edu/pub/kstanek/DIRECT/ and through WWW at http://cfa-www.harvard.edu/~kstanek/DIRECT

Modelling the Galactic Bar Using Red Clump Giants

The color-magnitude diagrams of $\sim 7 \times 10^5$ stars obtained for 12 fields across the Galactic bulge with the OGLE project reveal a well-defined population of bulge red clump giants. We find that the distributions of the apparent magnitudes of the red clump stars are systematically fainter when moving towards lower galactic $l$ fields. The most plausible explanation of this distinct trend is that the Galactic bulge is a bar, whose nearest end lies at positive galactic longitude. We model this Galactic bar by fitting for all fields the observed luminosity functions in the red clump region of the color-magnitude diagram. We find that almost regardless of the analytical function used to describe the 3-D stars distribution of the Galactic bar, the resulting models have the major axis inclined to the line of sight by $20-30\deg$, with axis ratios corresponding to $x_0:y_0:z_0=3.5:1.5:1$. This puts a strong constraint on the possible range of the Galactic bar models. Gravitational microlensing can provide us with additional constrains on the structure of the Galactic bar.Comment: submitted to the New Astronomy, 27 pages, 11 figures; also available at ftp://www.astro.princeton.edu/stanek/Barmodel and through WWW at http://www.astro.princeton.edu/~library/prep.htm

Color-Magnitude Diagram Distribution of the Bulge Red Clump Stars - Evidence for the Galactic Bar

The color-magnitude diagrams of $\sim 5\times 10^5$ stars obtained for 13 fields towards the Galactic bulge with the OGLE project reveal a well-defined population of bulge red clump stars. We find that the distributions of the extinction-adjusted apparent magnitudes of the red clump stars in fields lying at $l=\pm5\deg$ in galactic longitude differ by $0.37\pm0.025\;mag$. Assuming that the intrinsic luminosity distribution of the red clump stars is the same on both sides of the Galactic center, this implies that the distances to the red clump stars in the two fields differ by a factor of $1.185\pm0.015$. A plausible explanation of the observed difference in the luminosity distribution is that the Galactic bulge is a triaxial structure, or bar, which is inclined to the line of sight by no more than $45\deg$, with the part of the bar at the positive galactic longitude being closer to us. This agrees rather well with other studies indicating the presence of the bar in the center of the Galaxy. Color-magnitude diagram data are accessible over the computer network with anonymous {\tt ftp}.Comment: 10 pages, 6 figures, uses AAS LaTeX aaspp.sty macro, PostScript figures available through the anonymous ftp or on request, accepted for the publication in the ApJ

Germline-focused analysis of tumour-detected variants in 49,264 cancer patients: ESMO Precision Medicine Working Group recommendations

Germline; Tumour-only sequencingLínia germinal; Seqüenciació només de tumorsLínea germinal; Secuenciación solo de tumorsBackground The European Society for Medical Oncology Precision Medicine Working Group (ESMO PMWG) was reconvened to update its 2018/19 recommendations on follow-up of putative germline variants detected on tumour-only sequencing, which were based on an analysis of 17 152 cancers. Methods We analysed an expanded dataset including 49 264 paired tumour-normal samples. We applied filters to tumour-detected variants based on variant allele frequency, predicted pathogenicity and population variant frequency. For 58 cancer-susceptibility genes, we then examined the proportion of filtered tumour-detected variants of true germline origin [germline conversion rate (GCR)]. We conducted subanalyses based on the age of cancer diagnosis, specific tumour types and ‘on-tumour’ status (established tumour-gene association). Results Analysis of 45 472 nonhypermutated solid malignancy tumour samples yielded 21 351 filtered tumour-detected variants of which 3515 were of true germline origin. 3.1% of true germline pathogenic variants were absent from the filtered tumour-detected variants. For genes such as BRCA1, BRCA2 and PALB2, the GCR in filtered tumour-detected variants was >80%; conversely for TP53, APC and STK11 this GCR was <2%. Conclusion Strategic germline-focused analysis can prioritise a subset of tumour-detected variants for which germline follow-up will produce the highest yield of most actionable true germline variants. We present updated recommendations around germline follow-up of tumour-only sequencing including (i) revision to 5% for the minimum per-gene GCR, (ii) inclusion of actionable intermediate penetrance genes ATM and CHEK2, (iii) definition of a set of seven ‘most actionable’ cancer-susceptibility genes (BRCA1, BRCA2, PALB2, MLH1, MSH2, MSH6 and RET) in which germline follow-up is recommended regardless of tumour type.This work was supported by the European Society for Medical Oncology (no grant number)

Modelling the Galactic Bar Using Red Clump Stars

The color-magnitude diagrams of $\sim 1 \times 10^6$ stars obtained for 19 fields towards the Galactic bulge with the OGLE project reveal a well-defined population of bulge red clump stars. We found that the distributions of the extinction-adjusted apparent magnitudes of red clump stars in fields lying at $l=\pm5\deg$ in galactic longitude differ by $\sim 0.4\; mag$. A plausible explanation of this observed difference in the luminosity distribution is that the Galactic bulge is a triaxial structure, or a bar, which is inclined to the line of sight by no more than $45\deg$. The part of the bar at the positive galactic longitude is closer to us. Work is now under way to model the Galactic bar by fitting the observed luminosity functions in the red clump region for various fields. Preliminary results indicate that the angle of the inclination of the bar to the line of sight can be as small as $\sim20\deg$. Gravitational microlensing can provide us with additional constrains on the structure of the Galactic bar.Comment: 4 pages, uuencoded compressed PostScript, talk presented at the IAU Colloquium 157 "Barred Galaxies"; also available through WWW at http://www.astro.princeton.edu/~library/prep.htm

The optical gravitational lensing experiment: variable stars in globular clusters; 1, fields 5139A-C in Omega Centauri

Three fields covering the central part of the globular cluster Omega Cen were surveyed in a search for variable stars. We present V-band light curves for 22 periodic variables: 9 SX~Phe stars, 7 contact binaries, 5 detached or semi-detached binaries, and one spotted variable (FK Com or RS CVn type star). Only 2 of these variables were previously known. All SX Phe stars and all contact binaries from our sample belong to blue stragglers. Observed properties of these stars are consistent with their cluster membership. Of particular interest is detection of two well detached binaries with periods P=1.50 day and P=2.47 day. Further study of these two binaries can provide direct information about properties of turnoff stars in Omega Cen. An uncomplete light curve of a Mira variable known as V2 was obtained. We present V vs. V-I color-magnitude diagrams for the monitored part of the cluster