Stones, Bones and Homes: An Examination of Regionality in the Iron Age Settlements and Landscape of West Wales

West Wales in the Iron Age contained a diverse range of settlement types, from hill-forts to unenclosed farmsteads, with the dominant type of settlement the enclosed farmstead. However, a recent review of information available for the British Iron Age identified a relative lack of systematised information for Wales and consequently there is a pressing need to re-examine the settlement record for this area, as the belief in a single Iron Age "culture" gives way to recognition of regional difference in material cultures, social institutions and life-ways. This thesis examines the settlements and landscape of West Wales in an attempt to contribute to our understanding of this region in the Iron Age. In order to make a regionally synthesised investigation of the social, I conducted a survey of excavation and survey information for Iron Age settlements in West Wales. Analysis centred on examining the spatial patterning of settlements by considering the morphology, distribution, placement and structure of settlements, their place in the landscape and regional trends in the structuring of space and artefacts. The investigation was contextualised within the wider body of material for the Iron Age in Britain. The use of landscape theory as an interpretive framework in examining the spatial patterning of the material culture in the Iron Age proved an effective method for interpreting domestic settlements within the lived landscape. Social and cosmological relations within settlements and within the referential structuring of a landscape, particularly with respect to pre-existing monuments, were suggested by the analysis. By comparing these trends in the structuring of settlements within the landscape to settlements elsewhere in Britain, a distinct and regional culture for the Iron Age of West Wales was identified

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Developing a holistic and collaborative approach for the archaeology of Australian South Sea Islanders in Queensland

Publication status: PublishedABSTRACTAustralian South Sea Islanders are a distinctive cultural group comprising descendants of over 60000 labourers who came to Australia from Vanuatu, Solomon Islands and elsewhere in the Western Pacific between 1863 and 1904. “Blackbirded” labourers were commonly referred to as victims of a slave trade, though many also came voluntarily to work in the sugar plantations of northern New South Wales and Queensland. The advent of racist exclusionary immigration policies introduced from 1901 further forced South Sea Islanders to the margins of colonial society. Yet many Australian South Sea Islanders would argue their untold history speaks to resilience and overcoming adversity. Australian South Sea Islanders have a distinctive cultural heritage, including material culture, oral traditions embedded in the landscape and connections to places – from sugar mills to domestic sites – revealed archaeologically. This heritage must be approached sensitively given its association with sometimes difficult histories but is crucial to understanding the contributions of Australian South Sea Islanders to Australian society, contemporary communities and identities, and historical and social significance across multiple scales. Collaborative research with Australian South Sea Islanders pushes the boundaries of “community archaeology” by taking a slow approach to research, reframing ethnographic objects and cultural landscapes, and producing an archaeology that can include many voices.</jats:p

A dysfunctional desmin mutation in a patient with severe generalized myopathy

Mice lacking desmin produce muscle fibers with Z disks and normal sarcomeric organization. However, the muscles are mechanically fragile and degenerate upon repeated contractions. We report here a human patient with severe generalized myopathy and aberrant intrasarcoplasmic accumulation of desmin intermediate filaments. Muscle tissue from this patient lacks the wild-type desmin allele and has a desmin gene mutation encoding a 7-aa deletion within the coiled-coil segment of the protein. We show that recombinant desmin harboring this deletion cannot form proper desmin intermediate filament networks in cultured cells, nor is it able to assemble into 10-nm filaments in vitro. These findings provide direct evidence that a mutation in desmin can cause human myopathies

Kin, fictive kin and strategic movement: Working class heritage of the Upper Burnett

The Upper Burnett district of southeast Queensland, Australia is a landscape of working class resilience in the face of natural and institutional oppression. The Upper Burnett was the site of numerous small goldmining towns throughout the late nineteenth and early twentieth centuries. Physically, most of these towns now survive only as archaeological remnants, yet both the tangible heritage elements and the intangible forms of labour heritage, such as stories in the landscape and of movement between places, contribute to the shared and continued attachment of the Burnett community to its mining history. Historical archaeological, sociological and landscape studies, including long-term projects working with descendents of the mining families, have provided detailed insight into the palimpsest of meanings applied to the social landscape of the working class inhabitants. Oral history, documentary and archaeological research have been conducted on the townships of Paradise, Mount Shamrock, Monal and Cania. The cultural landscape of these towns can be seen as a complex heritage of working class pastimes, networks of labour through kin and fictive kin relationships, strategic movement across the region and the interaction between communities. Although the local museums tend to memorialise the physical heritage of the goldmining through collecting and displaying the impressive material culture (such as stampers, berdan pans, mine wheels, etc.), it is the stories, meanings, diaries, and the continued attachments to these places today that play the larger role in the remembering of the working class past

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016 : a systematic analysis for the Global Burden of Disease Study 2016

Background Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from all causes of injury in every country, to describe how these measures have changed between 1990 and 2016, and to estimate the proportion of TBI and SCI cases caused by different types of injury. Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2016 to measure the global, regional, and national burden of TBI and SCI by age and sex. We measured the incidence and prevalence of all causes of injury requiring medical care in inpatient and outpatient records, literature studies, and survey data. By use of clinical record data, we estimated the proportion of each cause of injury that required medical care that would result in TBI or SCI being considered as the nature of injury. We used literature studies to establish standardised mortality ratios and applied differential equations to convert incidence to prevalence of long-term disability. Finally, we applied GBD disability weights to calculate YLDs. We used a Bayesian meta-regression tool for epidemiological modelling, used cause-specific mortality rates for non-fatal estimation, and adjusted our results for disability experienced with comorbid conditions. We also analysed results on the basis of the Socio-demographic Index, a compound measure of income per capita, education, and fertility. Findings In 2016, there were 27.08 million (95% uncertainty interval [UI] 24.30-30.30 million) new cases of TBI and 0.93 million (0.78-1.16 million) new cases of SCI, with age-standardised incidence rates of 369 (331-412) per 100 000 population for TBI and 13 (11-16) per 100 000 for SCI. In 2016, the number of prevalent cases of TBI was 55.50 million (53.40-57.62 million) and of SCI was 27.04 million (24 .98-30 .15 million). From 1990 to 2016, the age-standardised prevalence of TBI increased by 8.4% (95% UI 7.7 to 9.2), whereas that of SCI did not change significantly (-0.2% [-2.1 to 2.7]). Age-standardised incidence rates increased by 3.6% (1.8 to 5.5) for TBI, but did not change significantly for SCI (-3.6% [-7.4 to 4.0]). TBI caused 8.1 million (95% UI 6. 0-10. 4 million) YLDs and SCI caused 9.5 million (6.7-12.4 million) YLDs in 2016, corresponding to age-standardised rates of 111 (82-141) per 100 000 for TBI and 130 (90-170) per 100 000 for SCI. Falls and road injuries were the leading causes of new cases of TBI and SCI in most regions. Interpretation TBI and SCI constitute a considerable portion of the global injury burden and are caused primarily by falls and road injuries. The increase in incidence of TBI over time might continue in view of increases in population density, population ageing, and increasing use of motor vehicles, motorcycles, and bicycles. The number of individuals living with SCI is expected to increase in view of population growth, which is concerning because of the specialised care that people with SCI can require. Our study was limited by data sparsity in some regions, and it will be important to invest greater resources in collection of data for TBI and SCI to improve the accuracy of future assessments. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.Peer reviewe

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field