Averaging Diffusion-weighted Images Affects the Analysis of the Diffusion Tensor in Vivo

Article信州医学雑誌 64(3): 113-121(2016)journal articl

Dosimetric Comparisons of Volumetric Modulated Arc Therapy with Three-Dimensional Conformal Radiation Therapy for Locally Advanced Non-Small Cell Lung Cancer

Article信州医学雑誌 65(2): 93-98(2017)journal articl

Functional Magnetic Resonance Imaging Study of Brain Activation by Sound Localization in Artificial Unilateral Hearing Loss

Article信州医学雑誌 64(3): 123-133(2016)journal articl

Risk Factors for Severe Dysphagia after Concurrent Chemoradiotherapy for Head and Neck Cancers

The aim of this study was to investigate the risk factors for dysphagia induced by chemoradiotherapy for head and neck cancers. Forty-seven patients with head and neck cancers who underwent definitive chemoradiotherapy from December 1998 to March 2006 were reviewed retrospectively. Median age was 63 years (range, 16-81). The locations of the primary lesion were as follows: larynx in 18 patients, oropharynx in 11, nasopharynx in 7, hypopharynx in 7 and others in 4. Clinical stages were as follows: Stage II in 20 and Stages III-IV in 27. Almost all patients underwent platinum-based concomitant chemoradiotherapy. The median cumulative dose of cisplatin was 100 mg/m(2) (range, 80-300) and median radiation dose was 70 Gy (range, 50-70). Severe dysphagia (Grade 3-4) was observed in 22 patients (47%) as an acute toxic event. One patient required tube feeding even at 12-month follow-up. In univariate analysis, clinical stage (III-IV) (P = 0.017), primary site (oro-hypopharynx) (P = 0.041) and radiation portal size (> 11 cm) (P < 0.001) were found to be associated with severe dysphagia. In multivariate analysis, only radiation portal size was found to have a significant relationship with severe dysphagia (P = 0.048). Larger radiation portal field was associated with severe dysphagia induced by chemoradiotherapy.ArticleJAPANESE JOURNAL OF CLINICAL ONCOLOGY. 39(7):413-417 (2009)journal articl

Predictive Factors for Deterioration of Lower Urinary Tract Symptoms After Iodine-125 Brachytherapy in Prostate Cancer Patients

Article信州医学雑誌 66(2): 131-137(2018)journal articl

Validation of the Total Dysphagia Risk Score (TDRS) as a predictive measure for acute swallowing dysfunction induced by chemoradiotherapy for head and neck cancers

Background and purpose: Methods for predicting acute swallowing dysfunction in patients with head and neck cancers undergoing definitive chemoradiotherapy have not been established. We investigated the validity of the Total Dysphagia Risk Score (TDRS) as a predictive measure for this morbidity. Materials and methods: Forty-seven patients with head and neck cancers who underwent definitive chemoradiotherapy between December 1998 and March 2006 were reviewed retrospectively. Median age was 63 years (range, 16-81). Almost all patients underwent platinum-based concomitant chemoradiotherapy. Factors of the TDRS were as follows: T-classification, neck irradiation, weight loss, primary tumour site and treatment modality. Patients were classified into three risk groups according to the TDRS. Results: Swallowing dysfunction was observed in 27 patients (57%) as RTOG grade 2 or higher acute morbidity. This classification was significantly associated with grade 2 or higher acute swallowing dysfunction (P = 3) acute swallowing dysfunction was similarly obtained. Conclusion: The TDRS is a useful tool to predict acute swallowing dysfunction induced by chemoradiotherapy for head and neck cancers.ArticleRADIOTHERAPY AND ONCOLOGY. 97(1):132-135 (2010)journal articl

肝細胞癌の磁気共鳴診断: 信号強度と病理組織像との対比を中心に

取得学位 : 博士（医学）, 学位授与番号 : 医博乙第1151号, 学位授与年月日：平成3年12月4日,学位授与年：199

磁気共鳴診断における網内系造影剤による肝細胞癌と境界病変の鑑別診断に関する研究

金沢大学医学部・附属病院1.ラットで実験的に作製した腫瘍性結節(NN)と肝細胞癌(HCC)について網内系造影剤であるフェライト粒子を用いMRIの信号強度に及ぼす影響について検討した。2.0.06% 3\u27ーmethy1ー4ーdimethylamino azobenzene混合飼料を6週間投与後、通常食に切り換えるとともに四塩化炭素2cc/kgとオリ-ブオイルの等量混合物を週2回13週皮下注射し以後無処置で飼育したウィスタ-系ラット12匹を用いた。MRI装置はGE社製Signa systemを用い、パルス系列としてSE500/20、SE2500/25、SE2500/80、SE800/20、SE800/40(いずれもスライス厚5mm、スライスギャップ1.5mm、マトリックス256×128、励起回数4回)を使用し、フェライト粒子(BioMag 4125)15μmol Fe/kgの静脈内投与前、投与1時間後の撮像を行った。全146結節のうち径5mm以上のHCC25結節、NN14結節について各パルス系列でのS/N比、C/N比、T2値を求め比較した。3.投与前後間でS/N比を比較するとHCC群ではいずれのパルス系列でも変化がなかったのに対し、NN群ではSE500/20を除くすべてのパルス系列で投与後有意に低下した。両群間のS/N比を比較すると投与前にはSE2500/80でのみでNN群が有意に低かったのに対し投与後はSE2500/25、SE800/40でも有意差がみられた。C/N比についてもほぼ同様の結果で投与後SE800/20を除くすべてのパルス系列両群間に有意差がみられた。T2値はHCC群に比べNN群では投与前後ともに有意に低く、NN群ではT2短縮が見られたのに対しHCC群では変化がなかった。4.フェライト粒子投与によりNNでは、S/N比の低下、T2値の短縮がみられ、HCCと比しC/N比の上昇程度が低く両者の鑑別に有用であった。人における肝細胞癌および腺腫様過形成を含めた肝癌類似病変との悪性度評価の一手段として有用性が期待できるものと思われる。研究課題/領域番号:02670490, 研究期間(年度):1990出典：研究課題「磁気共鳴診断における網内系造影剤による肝細胞癌と境界病変の鑑別診断に関する研究」課題番号02670490（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-02670490/）を加工して作

A Case of Pancreatic Carcinoma with Bilateral Hilar 18F-FDG and 67Ga Hyperaccumulation

Article信州医学雑誌 66(2): 151-155(2018)journal articl

Usefulness of F-18 FDG PET/CT in a Case of Relapsing Polychondritis

Article信州医学雑誌 64(6): 349-355(2016)journal articl