Elements of a talent strategy for effective relationship building: A study among bank sales and service managers

This study considers equity sensitivity, emotional labor and organizational commitment as three important variables that play a critical role among sales and service providers at a bank and the effect these variables ultimately have on corporate performance. Using an equity theory perspective, research hypotheses linking the various constructs are formulated. Data are collected from sales and service managers at a community bank and partial aggregation followed by structural equation modeling is used to test the hypotheses. Results are reported, implications to a bank\u2019s talent strategy are drawn, limitations are noted and directions for future research are indicated

Progression of Early Breast Cancer to an Invasive Phenotype

Histological and molecular evidence has led to a model of breast cancer progression in which cells from the terminal duct lobular unit give rise to atypical ductal hyperplasia or atypical lobular hyperplasia, which can progress to ductal carcinoma in situ or lobular carcinoma in situ, and eventually to invasive ductal carcinoma or invasive lobular carcinoma respectively. This review will present a histomorphological and epidemiological overview of the pre-invasive stages of breast cancer progression. As there is mounting evidence that these stages are likely rough phenotypes of underlying molecular changes, current knowledge regarding changes in genetic and epigenetic features of breast cancer progression will also be discussed. Microarray and CGH-based studies will be described, which suggest that low- and high-grade breast cancers can arise from normal terminal ducts through two distinct molecular pathways. Various in vitro and in vivo models used to study the cellular and molecular changes involved in early breast cancer progression will be presented. Lastly, the specific transition from pre-invasive to invasive breast cancer will be addressed, including possible molecular predictors of the invasive phenotype and a contemporary view highlighting the involvement of the tumor microenvironment during the transition to invasive disease

Premalignant and pre-invasive lesions of the breast

Premalignant and pre-invasive lesions of the breast belong to a complex and heterogeneous group of lesions and represent a matter of remarkable interest from both clinical and biological standpoints. These frequent noninvasive alterations are related with an increased probability of breast cancer development. What is more, these breast abnormalities show extremely variable risks of progression toward invasive forms of disease. Indeed, while there are many histologically defined premalignant lesions in the breast, only a subset of them constitute true neoplastic precursors that will progress to invasive cancer. Disappointingly, it is currently not conceivable to identify a priori, with absolute certainty, which of these precursors will progress and which not. Therefore, classifying risk indicators, precursors, and non-obligate precursors of invasive breast cancer, and ultimately define robust protocols for their clinical management, is a hot topic in the multidisciplinary approach to breast cancer patients, that involves pathologists, radiologists, surgeons, and oncologists