TRUST OF MODERNITY, MODERNITY OF TRUST. CONSIDERATIONS AND RESEARCH HYPOTHESIS

THE DEVELOPMENT SOCIAL RELATIONSHIP IN OUR TIMES IMPOSE A GROWING IMPORTANCE TO 'TRUST' AS A RESOURCE BETWEEN PERSONAL RELATIONSHIP AS BETWEEN PERSONS AND COMPLEX SOCIAL SYSTEM. THE MAIN FEATURE OF MODERNITY IN SOCIAL CONNECTIONS IS GIVEN BY THE SPREAD OF A 'TIME/SPACE' DISTANCE. THE INCREASING DIFFICULTIES OF RELATIONS BETWEEN PERSONS AND ENVIRONMENT FIX OUR CONSTANT NEED TO RECONSIDER OUR ACTIONS/DECISIONS WITH RISK AND TROUBLES, SO 'TRUSTING' IS GOING TO HAVE AN IMPORTANT ROLE AS REDUCING OF SOCIAL COMPLEXITY IN OUR NEAPOLITAN REALITY, WE ASSUME THAT IS BETTER TO 'RELIANCE' RATHER THAN TO TRUST. FOR THE REASON THAT WE DON'T HAVBE A GOOD REPRESENTATIONS OF OTHERS. SO, WE BUILD OUR PERSONAL CONNECTION WITH 'HOPE' AND 'FAITH' BECAUSE WE WONT TO DEFENCE OURSELVES FROM A SOCIAL ENVIRONMENT FELT LIKE DANGEROUS, THEREFORE WE NEED TO HAVE AN EXTERNAL AUTHORITY RATHER THAN TAKE CHANGE OF 'TRUSTING', BECAUSE WE BELIEVE THAT THE ACT OF TRUSTING IS AN ENGAGE/DEPENDENCE ON SOMEONE AND WE WONT TO AVOID THE RISK OF BEING DECEIVED. THESE SOCIAL INTERACTIONS ARE PRECONDITIONS THAT HAVE MANY CONSEQUENCES TO THE ECONOMIC ACTION AND FOR COOPERATION.TRUST, SOCIAL CAPITAL, RISK, RELIANCE, COOPERATION, CONFIDENCE, UNCERTAINTY

Cognitive behavioral group therapy versus psychoeducational intervention in Parkinson's disease

Objective: The aim of the current study was to evaluate whether cognitive behavioral group therapy has a positive impact on psychiatric, and motor and non-motor symptoms in Parkinson’s disease (PD). Methods: We assigned 20 PD patients with a diagnosis of psychiatric disorder to either a 12-week cognitive behavioral therapy (CBT) group or a psychoeducational protocol. For the neurological examination, we administered the Unified Parkinson’s Disease Rating Scale and the non-motor symptoms scale. The severity of psychiatric symptoms was assessed by means of the Hamilton Depression Rating Scale, the Hamilton Anxiety Rating Scale, the Brief Psychiatric Rating Scale, and the Clinical Global Impressions. Results: Cognitive behavioral group therapy was effective in treating depression and anxiety symptoms as well as reducing the severity of non-motor symptoms in PD patients; whereas, no changes were observed in PD patients treated with the psychoeducational protocol. Conclusion: CBT offered in a group format should be considered in addition to standard drug therapy in PD patient

Rare breast cancer subtypes: Histological, molecular, and clinical peculiarities

Breast cancer encompasses a collection of different diseases characterized by different biological and pathological features, clinical presentation, response to treatments, clinical behavior, and outcome. On the basis of cell morphology, growth, and architecture patterns, breast cancer can be classified in up to 21 distinct histological types. Breast cancer special types, including the classic lobular invasive carcinoma, represent 25% of all breast cancers. The histological diversity of breast carcinomas has relevant prognostic implications. Indeed, the rare breast cancer group includes subtypes with very different prognoses, ranging from the tubular carcinoma, associated with an indolent clinical course, to metaplastic cancer, whose outcome is generally unfavorable. New approaches based on gene expression profiling allow the identification of molecularly defined breast cancer classes, with distinct biological features and clinical behavior. In clinical practice, immunohistochemical classification based on the expression of human epidermal growth factor receptor 2 and Ki67 is applied as a surrogate of the intrinsic molecular subtypes. However, the identification of intrinsic molecular subtypes were almost completely limited to the study of ductal invasive breast cancer. Moreover, some good-prognosis triple-negative histotypes, on the basis of gene expression profiling, can be classified among the poor-prognosis group. Therefore, histopathological classification remains a crucial component of breast cancer diagnosis. Special histologies can be very rare, and the majority of information on outcome and treatments derives from small series and case reports. As a consequence, clear recommendations about clinical management are still lacking. In this review, we summarize current knowledge about rare breast cancer histologies.Breast cancer encompasses a collection of different diseases characterized by different biological and pathological features, clinical presentation, response to treatments, clinical behavior, and outcome. On the basis of cell morphology, growth, and architecture patterns, breast cancer can be classified in up to 21 distinct histological types. Breast cancer special types, including the classic lobular invasive carcinoma, represent 25% of all breast cancers. The histological diversity of breast carcinomas has relevant prognostic implications. Indeed, the rare breast cancer group includes subtypes with very different prognoses, ranging from the tubular carcinoma, associated with an indolent clinical course, to metaplastic cancer, whose outcome is generally unfavorable. New approaches based on gene expression profiling allow the identification of molecularly defined breast cancer classes, with distinct biological features and clinical behavior. In clinical practice, immunohistochemical classification based on the expression of human epidermal growth factor receptor 2 and Ki67 is applied as a surrogate of the intrinsic molecular subtypes. However, the identification of intrinsic molecular subtypes were almost completely limited to the study of ductal invasive breast cancer. Moreover, some good-prognosis triple-negative histotypes, on the basis of gene expression profiling, can be classified among the poor-prognosis group. Therefore, histopathological classification remains a crucial component of breast cancer diagnosis. Special histologies can be very rare, and the majority of information on outcome and treatments derives from small series and case reports. As a consequence, clear recommendations about clinical management are still lacking. In this review, we summarize current knowledge about rare breast cancer histologies. \ua9 AlphaMed Press

LA TECNICA DELL'UNDERSOWING PER IL CONTROLLO DEGLI INSETTI FITOFAGI SU COLTURE ORTICOLE

La tecnica dell'undersowing consiste nella coltivazione di una specie "secondaria" traseminata sulla fila e nell'interfila della coltura principale con l'obiettivo di ridurre le popolazioni degli insetti fitofagi maggiormente dannosi per la coltura. Risultati incoraggianti sono stati raggiunti su coltura di cavolo verza trapiantata su trifolium repens (L.). Ulteriori conferme sono da ricercare sull'utilizzo di tale tecnica su altre colture orticole ponendo particolare attenzione ai possibili effetti competitivi della specie secondaria sulla coltura da reddito

Transformed Follicular Lymphoma: Not all fit in one

Follicular Lymphoma (FL) is the second most frequent non-Hodgkin lymphoma accounting for approximately 10-20% of all lymphomas in Western Countries. Histologic transformation (HT) is a frequent event in the clini-cal course of patients with indolent lymphoma that is often accompanied by a dramatic change in the clinical fea-tures of the disease towards a more aggressive course. Although the transformation of Follicular Lymphoma (tFL) was described several decades ago, there is a strong need for a better understanding of both the dynamics of the tumor clonal evolution and the genetic events leading to ()transformation. In addition, the management of patients with tFL is challenged by the heterogeneity of the previous treatments. The present review describes the state of art of tFL, outlining recent advances in the understanding of genetic basis and the evolutionary pro-cess governing the initiation and persistence of tumor evolution. It will be also addressed the key questions pend-ing on this incurable disease, such as a lack of a standard therapeutic strategy for tFL patients as well as its out-come in the Rituximab (R) era

Sonication of antibiotic-loaded cement spacers in a two-stage revision protocol for infected joint arthroplasty

Background. Culturing of the sonication fluid of removed implants has proven to be more sensitive than conventional periprosthetic tissue culture for the microbiological diagnosis of prosthetic joint infection. Since bacteria surviving on antibiotic-loaded cement spacers used in a two-stage exchange protocol for infected arthroplasties may cause the persistence of infection, in this study we asked whether the sonication also could be used to identify bacteria on antibiotic-loaded cement spacers removed at the second surgical stage during a two-stage exchange procedure to confirm whether or not the prosthetic joint infection had been eradicated. Methods. We cultured the sonication fluid of cement spacers that had been originally implanted in a two-stage exchange protocol in 21 patients (mean age, 66 years) affected by prosthetic joint infection (16 total knee prostheses and 5 hip prostheses). The cement spacers were vortexed for 30 seconds and then subjected to sonication (frequency 35–40 KHz). The resulting sonicate fluid was cultured for aerobic and anaerobic bacteria. Results. The sonication fluid culture of the removed spacer was positive in six patients (29%), with isolation of methicillin-sensible Staphylococcus Aureus (MSSA) in three cases, methicillin-resistant Staphylococcus Aureus (MRSA) in one case and Pseudomonas Aeruginosa in two cases. In three of these positive cases, the traditional culture of periprosthetic tissue was negative. Two patients with positive sonication culture of the spacer were successfully treated by early debridement of the revision prosthesis and systemic antibiotic therapy. In three patients a knee arthrodesis was planned and performed as the second surgical stage. In two of them the infection was caused by highly resistant Pseudomonas Aeruginosa. The other patient with a MSSA infection had been poorly compliant with the systemic antibiotic therapy due to her mental impairment. The patient originally affected by MRSA infection of his primary hip arthroplasty developed recurrent infection of his revision prosthesis and eventually underwent Girdlestone arthroplasty. Conclusions. The sonication culture can be used to discover any bacteria on the antibiotic-loaded cement spacer during a two-stage exchange protocol, thus permitting the adoption of timely treatment options, such as the early prosthetic debridment

Recommender systems: a novel approach based on singular value decomposition

Due to modern information and communication technologies (ICT), it is increasingly easier to exchange data and have new services available through the internet. However, the amount of data and services available increases the difficulty of finding what one needs. In this context, recommender systems represent the most promising solutions to overcome the problem of the so-called information overload, analyzing users' needs and preferences. Recommender systems (RS) are applied in different sectors with the same goal: to help people make choices based on an analysis of their behavior or users' similar characteristics or interests. This work presents a different approach for predicting ratings within the model-based collaborative filtering, which exploits singular value factorization. In particular, rating forecasts were generated through the characteristics related to users and items without the support of available ratings. The proposed method is evaluated through the MovieLens100K dataset performing an accuracy of 0.766 and 0.951 in terms of mean absolute error and root-mean-square error