Учет материально-производственных запасов на примере ООО "Доминанта-мебель"

В данной работе рассматриваются теоретические основы и учет материальных затрат в ООО "Доминанта мебель". Даны рекомендации по совершенствованию учета и управлению материальными затратами.In this paper, we consider the theoretical basis and accounting of material costs in Dominanta Mebel. Recommendations are given for improving the accounting and management of material costs in the enterprise

Design of Group IIA Secreted/Synovial Phospholipase A2 Inhibitors: An Oxadiazolone Derivative Suppresses Chondrocyte Prostaglandin E2 Secretion

Group IIA secreted/synovial phospholipase A2 (GIIAPLA2) is an enzyme involved in the synthesis of eicosanoids such as prostaglandin E2 (PGE2), the main eicosanoid contributing to pain and inflammation in rheumatic diseases. We designed, by molecular modeling, 7 novel analogs of 3-{4-[5(indol-1-yl)pentoxy]benzyl}-4H-1,2,4-oxadiazol-5-one, denoted C1, an inhibitor of the GIIAPLA2 enzyme. We report the results of molecular dynamics studies of the complexes between these derivatives and GIIAPLA2, along with their chemical synthesis and results from PLA2 inhibition tests. Modeling predicted some derivatives to display greater GIIAPLA2 affinities than did C1, and such predictions were confirmed by in vitro PLA2 enzymatic tests. Compound C8, endowed with the most favorable energy balance, was shown experimentally to be the strongest GIIAPLA2 inhibitor. Moreover, it displayed an anti-inflammatory activity on rabbit articular chondrocytes, as shown by its capacity to inhibit IL-1β-stimulated PGE2 secretion in these cells. Interestingly, it did not modify the COX-1 to COX-2 ratio. C8 is therefore a potential candidate for anti-inflammatory therapy in joints

Les nonylphénols et leurs dérivés (impact sur la santé humaine et l'environnement)

PARIS-BIUP (751062107) / SudocSudocFranceF

Les phtalates (toxicité, risques sanitaires, aspects réglementaires)

PARIS-BIUP (751062107) / SudocSudocFranceF

Etude pharmaco-toxicologique de nouvelles molécules anti-pla

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

Traitement de l'infection par le virus de l'immunodéficience humaine (toxicité métabolique des inhibiteurs de protéase)

PARIS-BIUP (751062107) / SudocSudocFranceF

Etude du rapport bénéfice/risque des coxibs (cas particulier du vioxx)

PARIS-BIUP (751062107) / SudocSudocFranceF

Le dopage et ses conséquences sur le système cardiovasculaire

PARIS-BIUP (751062107) / SudocSudocFranceF

Pharmacogénétique et hypertension essentielle (influence génétique sur la réponse aux traitements)

PARIS-BIUP (751062107) / SudocSudocFranceF

Cardiotoxicité des anthracyclines (détection précoce et perspectives thérapeutiques)

PARIS-BIUP (751062107) / SudocSudocFranceF