Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012

Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging viral pathogen that primarily causes respiratory illness. We conducted a seroprevalence study of banked human serum samples collected in 2012 from Southern Saudi Arabia. Sera from 300 animal workers (17% with daily camel exposure) and 50 non-animal-exposed controls were examined for serological evidence of MERS-CoV infection by a pseudoparticle MERS-CoV spike protein neutralization assay. None of the sera reproducibly neutralized the MERS-CoV-pseudotyped lentiviral vector. These data suggest that serological evidence of zoonotic transmission of MERS-CoV was not common among animal workers in Southern Saudi Arabia during July 2012.published_or_final_versio

Towards the critical behavior for the light nuclei by NIMROD detector

The critical behavior for the light nuclei with A$\sim 36$ has been investigated experimentally by the NIMROD multi-detectors. The wide variety of observables indicate the critical point has been reached in the disassembly of hot nuclei at an excitation energy of 5.6$\pm$0.5 MeV/u.Comment: 4 pages, 2 figures; Proceeding of 18th Nuclear Physics Division Conference of the Euro. Phys. Society (NPDC18) "Phase transitions in strongly interacting matter", Prague, 23.8.-29.8. 2004. To be published in Nuclear Physics

Laboratory Tests of Low Density Astrophysical Equations of State

Clustering in low density nuclear matter has been investigated using the NIMROD multi-detector at Texas A&M University. Thermal coalescence modes were employed to extract densities, $\rho$, and temperatures, $T$, for evolving systems formed in collisions of 47 $A$ MeV $^{40}$Ar + $^{112}$Sn,$^{124}$Sn and $^{64}$Zn + $^{112}$Sn, $^{124}$Sn. The yields of $d$, $t$, $^{3}$He, and $^{4}$He have been determined at $\rho$ = 0.002 to 0.032 nucleons/fm$^{3}$ and $T$= 5 to 10 MeV. The experimentally derived equilibrium constants for $\alpha$ particle production are compared with those predicted by a number of astrophysical equations of state. The data provide important new constraints on the model calculations.Comment: 5 pages, 3 figure

Evidence of Critical Behavior in the Disassembly of Nuclei with A ~ 36

A wide variety of observables indicate that maximal fluctuations in the disassembly of hot nuclei with A ~ 36 occur at an excitation energy of 5.6 +- 0.5 MeV/u and temperature of 8.3 +- 0.5 MeV. Associated with this point of maximal fluctuations are a number of quantitative indicators of apparent critical behavior. The associated caloric curve does not appear to show a flattening such as that seen for heavier systems. This suggests that, in contrast to similar signals seen for liquid-gas transitions in heavier nuclei, the observed behavior in these very light nuclei is associated with a transition much closer to the critical point.Comment: v2: Major changes, new model calculations, new figure

Critical Behavior in Light Nuclear Systems: Experimental Aspects

An extensive experimental survey of the features of the disassembly of a small quasi-projectile system with $A \sim$ 36, produced in the reactions of 47 MeV/nucleon $^{40}$Ar + $^{27}$Al, $^{48}$Ti and $^{58}$Ni, has been carried out. Nuclei in the excitation energy range of 1-9 MeV/u have been investigated employing a new method to reconstruct the quasi-projectile source. At an excitation energy $\sim$ 5.6 MeV/nucleon many observables indicate the presence of maximal fluctuations in the de-excitation processes. The fragment topological structure shows that the rank sorted fragments obey Zipf's law at the point of largest fluctuations providing another indication of a liquid gas phase transition. The caloric curve for this system shows a monotonic increase of temperature with excitation energy and no apparent plateau. The temperature at the point of maximal fluctuations is $8.3 \pm 0.5$ MeV. Taking this temperature as the critical temperature and employing the caloric curve information we have extracted the critical exponents $\beta$, $\gamma$ and $\sigma$ from the data. Their values are also consistent with the values of the universality class of the liquid gas phase transition. Taken together, this body of evidence strongly suggests a phase change in an equilibrated mesoscopic system at, or extremely close to, the critical point.Comment: Physical Review C, in press; some discussions about the validity of excitation energy in peripheral collisions have been added; 24 pages and 32 figures; longer abstract in the preprin

Apelin promotes lymphangiogenesis and lymph node metastasis

Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in angiogenesis has been well documented, the ability of the apelin/APJ system to induce lymphangiogenesis and lymphatic metastasis has been largely unexplored. To this end, we first show that APJ is expressed in lymphatic endothelial cells (LECs) and, moreover, that it responds to apelin by activating the apelinergic signaling cascade. We find that although apelin treatment does not influence the proliferation of LECs in vitro, it enhances their migration, protects them against UV irradiation-induced apoptosis, increases their spheroid numbers in 3D culture, stimulates their in vitro capillary-like tube formation and, furthermore, promotes the invasive growth of lymphatic microvessels in vivo in the matrigel plug assay. We also demonstrate that apelin overexpression in malignant cells is associated with accelerated in vivo tumor growth and with increased intratumoral lymphangiogenesis and lymph node metastasis. These results indicate that apelin induces lymphangiogenesis and, accordingly, plays an important role in lymphatic tumor progression. Our study does not only reveal apelin as a novel lymphangiogenic factor but might also open the door for the development of novel anticancer therapies targeting lymphangiogenesis

Tracing the Evolution of Temperature in Near Fermi Energy Heavy Ion Collisions

The kinetic energy variation of emitted light clusters has been employed as a clock to explore the time evolution of the temperature for thermalizing composite systems produced in the reactions of 26A, 35A and 47A MeV $^{64}$Zn with $^{58}$Ni, $^{92}$Mo and $^{197}$Au. For each system investigated, the double isotope ratio temperature curve exhibits a high maximum apparent temperature, in the range of 10-25 MeV, at high ejectile velocity. These maximum values increase with increasing projectile energy and decrease with increasing target mass. The time at which the maximum in the temperature curve is reached ranges from 80 to 130 fm/c after contact. For each different target, the subsequent cooling curves for all three projectile energies are quite similar. Temperatures comparable to those of limiting temperature systematics are reached 30 to 40 fm/c after the times corresponding to the maxima, at a time when AMD-V transport model calculations predict entry into the final evaporative or fragmentation stage of de-excitation of the hot composite systems. Evidence for the establishment of thermal and chemical equilibrium is discussed.Comment: 9 pages, 5 figure

A Ghoshal-like Test of Equilibration in Near-Fermi-Energy Heavy Ion Collisions

Calorimetric and coalescence techniques have been employed to probe equilibration for hot nuclei produced in heavy ion collisions of 35 to 55 MeV/u projectiles with medium mass targets. Entrance channel mass asymmetries and energies were selected in order that very hot composite nuclei of similar mass and excitation would remain after early stage pre-equilibrium particle emission. Inter-comparison of the properties and de-excitation patterns for these different systems provides evidence for the production of hot nuclei with decay patterns relatively independent of the specific entrance channel.Comment: 7 pages, 2 figure

Properties of the Initial Participant Matter Interaction Zone in Near Fermi-Energy Heavy Ion Collisions

The sizes, temperatures and free neutron to proton ratios of the initial interaction zones produced in the collisions of 40 MeV/nucleon $^{40}$Ar + $^{112}$Sn and 55 MeV/nucleon$^{27}$Al + $^{124}$Sn are derived using total detected neutron plus charged particle multiplicity as a measure of the impact parameter range and number of participant nucleons. The size of the initial interaction zone, determined from a coalescence model analysis, increases significantly with decreasing impact parameter. The temperatures and free neutron to proton ratios in the interaction zones are relatively similar for different impact parameter ranges and evolve in a similar fashion.Comment: 7 pages, 8 figure