Evaluation of dietary patterns among individuals submitted to bariatric surgery

Univ Fed Sao Paulo, Paulista Med Sch UNIFESP, Sao Paulo, BrazilUniv Minnesota Twin Cities, Minneapolis, MN USAHosp Clin UFPR, Bariatr Surg Serv, Curitiba, Parana, BrazilFed Univ Parana UFPR, Curitiba, Parana, BrazilUniv Fed Sao Paulo, Paulista Med Sch UNIFESP, Sao Paulo, BrazilWeb of Scienc

Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism

Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)AFIPUNIFESP-EPMConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Sao Paulo, Dept Biophys, 669 Pedro de Toledo St,9th, BR-04039032 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Biophys, 669 Pedro de Toledo St,9th, BR-04039032 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Program Nutr, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, BrazilCAPES: AUX-PE-PNPD 256/2011FAPESP: 2015/20082-7FAPESP: 2013/041364FAPESP: 2011/50356-0FAPESP: 2011/50414-0CNPq: 141533/2012-9Web of Scienc

The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy

The purpose of the present study was to evaluate if interdisciplinary therapy can influence the cardiometabolic and serum free fatty acid profile. The second aim was to evaluate if there is an association between serum free fatty acids, inflammation and cardiometabolic biomarkers in obese adolescents with and without metabolic syndrome submitted to a long-term interdisciplinary therapy. The study involved 108 postpuberty obese adolescents, who were divided according to metabolic syndrome (MetS) diagnosis: MetS (n=32) and Non-MetS (n=76). The interdisciplinary therapy consisted of a 1-year period of nutrition, psychology, physical exercise and clinical support. After therapy, both groups improved metabolic, inflammatory (leptin, adiponectin, leptin/adiponectin ratio, adiponectin/leptin ratio and C-reactive protein) and cardiometabolic profile (PAI-1 and ICAM). Metabolic syndrome prevalence reduced from 28.70% to 12.96%. Both groups reduced myristic acid (C14:0) and increased docosahexaenoic acid (DHA, C22:6n3), heneicosapentaenoic acid (HPA, C21:5n3) and arachidonic acid (C20:4n6). After adjustment for metabolic syndrome and the number of metabolic syndrome parameters, multiple regression analysis showed that changes in VCAM and PAI-1 were negatively associated with changes in cis-linoleic acid (C18:2n6c). Additionally, changes in trans-linoleic acid (C18:2n6t) were also positively associated with these biomarkers. Moreover, leptin and leptin/adiponectin ratio were negatively associated with changes in docosapentaenoic acid (DPA, C22:5n3) and stearidonic acid (SDA, C18:4n3). Adiponectin/leptin ratio was positively associated with docosapentaenoic acid (DPA, C22:5n3). Changes in adiponectin were positively correlated with changes in omega 3, such as heneicosapentaenoic acid (HPA, C21:5n3) and docosapentaenoic acid (DPA, C22:5n3). Results support that interdisciplinary therapy can control inflammatory and cardiometabolic profile in obese adolescents. Moreover, serum fatty acids can be influenced by lifestyle changes and are able to modulate these biomarkers. (C) 2016 Elsevier Inc. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo (UNIFESP)AFIPCEPECEMSAUniv Fed Sao Paulo, UNIFESP, Programa Posgrad Nutr, Sao Paulo, BrazilCtr Univ Sao Camilo, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Fisiol Nutr, UNIFESP, Sao Paulo, BrazilUniv Sao Paulo, Inst Biociencias, Dept Fisiol Geral, BR-05508 Sao Paulo, BrazilWeight Sci, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psicobiol, UNIFESP, Sao Paulo, BrazilUniv Fed Sao Paulo, UNIFESP, Programa Posgrad Nutr, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psicobiol, UNIFESP, Sao Paulo, BrazilCNPq: 141533/2012-9CNPq: 300654/2013-8CAPES: AUX-PE-PNPD 2566/2011FAPESP: 2011/50356-0FAPESP: 2011/50414-0FAPESP: 2013/041364Web of Scienc