Optic Nerve Head and Macular Optical Coherence Tomography Measurements in Papilledema Compared With Pseudopapilledema

Background:To compare macular and optic nerve headoptical coherence tomography (OCT) measurements in mildto moderate papilledema and pseudopapilledema.Methods:One hundred nineteen eyes of 61 patients withmild to moderate papilledema, 84 eyes of 48 patients withpseudopapilledema, and 60 eyes of 60 healthy normalindividuals were enrolled in this cross-sectional study. UsingSpectralis SD-OCT, macular scans with macular ganglioncell-inner plexiform layer (GCIPL) and macular retinal nervefiber layer (RNFL) segmentation were performed and dividedinto 2 regions (inner and outer, with a diameter of 3 and6 mm, respectively); in addition, Bruch membrane opening(BMO) area and peripapillary RNFL thickness were obtained.Results:BMO area was similar in papilledema (1.83 ±0.34 mm2), pseudopapilledema (1.85 ± 0.37 mm2), andcontrols (1.85 ± 0.32 mm2). Average inner region macularGCIPL thickness in the papilledema, pseudopapilledema,and control groups was 87.2 ± 14.4mm, 90.8 ± 6.1mm,and 91.2 ± 9.8mm, respectively (P.0.05). Outer temporalregion macular GCIPL was significantly thinner in the papil-ledema group compared with control group (P= 0.01). Bycontrast, outer inferior and outer nasal macular RNFL sec-tors were significantly thicker in the papilledema group com-pared with control groups (P= 0.01 andP,0.01,respectively). Those measures were not different betweenpseudopapilledema and control eyes.Conclusions:In papilledema eyes, outer temporal regionmacular GCIPL thickness decreased and outer inferior andouter nasal macular RNFL sectors thickness increased compared with the control group. These changes were notobserved in the pseudopapilledema group