Balanced and Restored Cross-Sections Representing Post-Miocene Crustal Extension of Fluvial Deposits, North-Central Montana to Southeast Idaho

This research is part of a larger project based on the theory of the existence of a pre-ice age, Amazon-scale river that had headwaters in the southern Colorado Plateau and flowed north through the western United States and Canada before discharging into the Labrador Sea. Stream-rounded fluvial deposits in Montana and Idaho provide evidence of sediment provenance in Nevada and Utah, as there are no confirmed bedrock sources for these sediments in Montana or Idaho. The Miocene river bed has been offset and tilted by dozens of extensional faults in the region. Some faults bound large mountain ranges including the Lost River, Lemhi, Beaverhead, Tendoy, Blacktail Deer, Ruby, Madison, and Big Belt Mountains. The reconstructed trend of the Miocene river bed provides a reference line against which to measure active faulting. We constructed five balanced cross-sections of the deformed subsurface along the Miocene river bed from north-central Montana to southeast Idaho across the faulted mountain ranges and restored the cross-sections to represent an un-deformed subsurface. This provided valuable insight into crustal deformation in these regions. Knowing the timing and extent of crustal deformation has many scientific and societal benefits. Western Montana and adjacent Idaho occupy the Inter-mountain Seismic Zone and have the potential for large earthquakes. Detailed cross-sections through this zone can provide information for development projects in faulted areas, and target potential aquifer locations where the thick river gravel has been down-faulted into the sub-surface. This research will be an important contribution to understanding the evolution of the tectonic landscape of Montana and Idaho

The children\u27s brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children\u27s Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN\u27s 32 member institutions utilize a shared regulatory governance architecture at the Children\u27s Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for \u3e 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors

The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community. The CBTN's 32 member institutions utilize a shared regulatory governance architecture at the Children's Hospital of Philadelphia to accelerate and maximize the use of biospecimens and data. As of August 2022, CBTN has enrolled over 4700 subjects, over 1500 parents, and collected over 65,000 biospecimen aliquots for research. Additionally, over 80 preclinical models have been developed from collected tumors. Multi-omic data for over 1000 tumors and germline material are currently available with data generation for > 5000 samples underway. To our knowledge, CBTN provides the largest open-access pediatric brain tumor multi-omic dataset annotated with longitudinal clinical and outcome data, imaging, associated biospecimens, child-parent genomic pedigrees, and in vivo and in vitro preclinical models. Empowered by NIH-supported platforms such as the Kids First Data Resource and the Childhood Cancer Data Initiative, the CBTN continues to expand the resources needed for scientists to accelerate translational impact for improved outcomes and quality of life for children with brain and spinal cord tumors