7 research outputs found

    Towards operational validation of annual global land cover maps

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    Annual global land cover maps (GLC) are being provided by several operational monitoring efforts. However, map validation is lagging, in the sense that the annual land cover maps are often not validated. Concurrently, users such as the climate and land management community require information on the temporal consistency of multi-date GLC maps and stability in their accuracy. In this study, we propose a framework for operational validation of annual global land cover maps using efficient means for updating validation datasets that allow timely map validation according to recommendations in the CEOS Stage-4 validation guidelines. The framework includes a regular update of a validation dataset and continuous map validation. For the regular update of a validation dataset, a partial revision of the validation dataset based on random and targeted rechecking (areas with a high probability of change) is proposed followed by additional validation data collection. For continuous map validation, an accuracy assessment of each map release is proposed including an assessment of stability in map accuracy addressing the user needs on the temporal consistency information of GLC map and map quality. This validation approach was applied to the validation of the Copernicus Global Land Service GLC product (CGLS-LC100). The CGLS-LC100 global validation dataset was updated from 2015 to 2019. The update was done through a partial revision of the validation dataset and an additional collection of sample validation sites. From the global validation dataset, a total of 40% (10% for each update year) was revisited, supplemented by a targeted revision focusing on validation sample locations that were identified as possibly changed using the BFAST time series algorithm. Additionally, 6720 sample sites were collected to represent possible land cover change areas within 2015 and 2019. Through this updating mechanism, we increased the sampling intensity of validation sample sites in possible land cover change areas within the period. Next, the dataset was used to validate the annual GLC maps of the CGLS-LC100 product for 2015–2019. The results showed that the CGLS-LC100 annual GLC maps have about 80% overall accuracy showing high temporal consistency in general. In terms of stability in class accuracy, herbaceous wetland class showed to be the least stable over the period. As more operational land cover monitoring efforts are upcoming, we emphasize the importance of updated map validation and recommend improving the current validation practices and guidelines towards operational map validation so that long-term land cover maps and their uncertainty information are well understood and properly used

    Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial

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    Background: Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functional outcome in patients with ischaemic wake-up stroke selected using non-contrast CT. Methods: TWIST was an investigator-initiated, multicentre, open-label, randomised controlled trial with blinded endpoint assessment, conducted at 77 hospitals in ten countries. We included patients aged 18 years or older with acute ischaemic stroke symptoms upon awakening, limb weakness, a National Institutes of Health Stroke Scale (NIHSS) score of 3 or higher or aphasia, a non-contrast CT examination of the head, and the ability to receive tenecteplase within 4·5 h of awakening. Patients were randomly assigned (1:1) to either a single intravenous bolus of tenecteplase 0·25 mg per kg of bodyweight (maximum 25 mg) or control (no thrombolysis) using a central, web-based, computer-generated randomisation schedule. Trained research personnel, who conducted telephone interviews at 90 days (follow-up), were masked to treatment allocation. Clinical assessments were performed on day 1 (at baseline) and day 7 of hospital admission (or at discharge, whichever occurred first). The primary outcome was functional outcome assessed by the modified Rankin Scale (mRS) at 90 days and analysed using ordinal logistic regression in the intention-to-treat population. This trial is registered with EudraCT (2014–000096–80), ClinicalTrials.gov (NCT03181360), and ISRCTN (10601890). Findings: From June 12, 2017, to Sept 30, 2021, 578 of the required 600 patients were enrolled (288 randomly assigned to the tenecteplase group and 290 to the control group [intention-to-treat population]). The median age of participants was 73·7 years (IQR 65·9–81·1). 332 (57%) of 578 participants were male and 246 (43%) were female. Treatment with tenecteplase was not associated with better functional outcome, according to mRS score at 90 days (adjusted OR 1·18, 95% CI 0·88–1·58; p=0·27). Mortality at 90 days did not significantly differ between treatment groups (28 [10%] patients in the tenecteplase group and 23 [8%] in the control group; adjusted HR 1·29, 95% CI 0·74–2·26; p=0·37). Symptomatic intracranial haemorrhage occurred in six (2%) patients in the tenecteplase group versus three (1%) in the control group (adjusted OR 2·17, 95% CI 0·53–8·87; p=0·28), whereas any intracranial haemorrhage occurred in 33 (11%) versus 30 (10%) patients (adjusted OR 1·14, 0·67–1·94; p=0·64). Interpretation: In patients with wake-up stroke selected with non-contrast CT, treatment with tenecteplase was not associated with better functional outcome at 90 days. The number of symptomatic haemorrhages and any intracranial haemorrhages in both treatment groups was similar to findings from previous trials of wake-up stroke patients selected using advanced imaging. Current evidence does not support treatment with tenecteplase in patients selected with non-contrast CT. Funding: Norwegian Clinical Research Therapy in the Specialist Health Services Programme, the Swiss Heart Foundation, the British Heart Foundation, and the Norwegian National Association for Public Health

    A Survey of Experimental Research on Contests, All-Pay Auctions and Tournaments

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    Many economic, political and social environments can be described as contests in which agents exert costly efforts while competing over the distribution of a scarce resource. These environments have been studied using Tullock contests, all-pay auctions and rankorder tournaments. This survey provides a review of experimental research on these three canonical contests. First, we review studies investigating the basic structure of contests, including the contest success function, number of players and prizes, spillovers and externalities, heterogeneity, and incomplete information. Second, we discuss dynamic contests and multi-battle contests. Then we review research on sabotage, feedback, bias, collusion, alliances, and contests between groups, as well as real-effort and field experiments. Finally, we discuss applications of contests to the study of legal systems, political competition, war, conflict avoidance, sales, and charities, and suggest directions for future research. (author's abstract
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