94 research outputs found
Venous Graft-Derived Cells Participate in Peripheral Nerve Regeneration
Background: Based on growing evidence that some adult multipotent cells necessary for tissue regeneration reside in the walls of blood vessels and the clinical success of vein wrapping for functional repair of nerve damage, we hypothesized that the repair of nerves via vein wrapping is mediated by cells migrating from the implanted venous grafts into the nerve bundle. Methodology/Principal Findings: To test the hypothesis, severed femoral nerves of rats were grafted with venous grafts from animals of the opposite sex. Nerve regeneration was impaired when decellularized or irradiated venous grafts were used in comparison to untreated grafts, supporting the involvement of venous graft-derived cells in peripheral nerve repair. Donor cells bearing Y chromosomes integrated into the area of the host injured nerve and participated in remyelination and nerve regeneration. The regenerated nerve exhibited proper axonal myelination, and expressed neuronal and glial cell markers. Conclusions/Significance: These novel findings identify the mechanism by which vein wrapping promotes nerve regeneration. © 2011 Lavasani et al
Clinical quality measures for intraoperative and perioperative management in carpal tunnel surgery
Mutagenesis and Characterization of Rhesus Cytomegalovirus Rh111 and Rh112 Open Reading Frames
Anatomic course of the medial antebrachial cutaneous nerve: a cadaveric study with proposed clinical application in failed cubital tunnel release
The effect of wrapping scarred nerves with autogenous vein graft to treat recurrent chronic nerve compression
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