Demandas Priorizadas e Análise De Documentos De Patentes Para Inovação Em Produtos, Processos E Serviços Derivados Do Aproveitamento De Resíduos Rurais, Urbanos E Agroindustriais.

bitstream/item/77113/1/DOC52-2010.pd

Aspectos Teóricos e Perspectivas da Aplicação do Método de Rietveld à Quantificação Mineralógica de Solos.

bitstream/CNPDIA/10466/1/BPD13_2005.pd

Electrochemical Investigations of Sydnone Derivatives at Glassy Carbon Electrode

Electrochemical reduction of the –N=N– moiety of sydnone derivatives, like 3-phenyl sydnone, tolyl sydnone and anisyl sydnone, was studied using cyclic voltammetry at a glassy carbon electrode. In acid medium, the above compounds were found to show irreversible electrochemical charge transfer in the pH range studied. Electrochemical studies of these sydnones were carried out in partially aqueous media containing organic co-solvents such as acetonitrile, dimethylformamide, methanol and dimethylsulphoxide. Physical parameters such as the charge transfer coefficient and diffusion coefficient, as well as the effects of variation of the electroactive species concentration, sweep rate, organic solvents, and pH on peak parameters were studied. The reduced products were characterized by IR, NMR and mass spectral studies. The effect of surfactants on the electrochemical reduction of 3-phenyl sydnone was studied using cationic, anionic and non-ionic surfactants

Network Protein Interaction in the Link between Stroke and Periodontitis Interplay: A Pilot Bioinformatic Analysis

The clinical interaction between stroke and periodontitis has been consistently studied and confirmed. Hence, exploring potentially new protein interactions in this association using bioinformatic strategies presents potential interest. In this exploratory study, we conducted a protein–protein network interaction (PPI) search with documented encoded proteins for both stroke and periodontitis. Genes of interest were collected via GWAS database. The STRING database was used to predict the PPI networks, first in a sensitivity purpose (confidence cut-off of 0.7), and then with a highest confidence cut-off (0.9). Genes over-representation was inspected in the final network. As a result, we foresee a prospective protein network of interaction between stroke and periodontitis. Inflammation, pro-coagulant/pro-thrombotic state and, ultimately, atheroma plaque rupture is the main biological mechanism derived from the network. These pilot results may pave the way to future molecular and therapeutic studies to further comprehend the mechanisms between these two conditions

Impurity-Band Model for GaP1-xNx

Low-temperature absorption studies on free-standing GaP1-xNx films provide direct experimental evidence that the host conduction-band minimum (CBM) near X1C does not plunge downward with increased nitrogen doping, contrary to what has been suggested recently; rather, it remains stationary for x up to 0.1%. This fact, combined with the results of earlier studies of the CBM at ..GAMMA.. and conduction-band edge near L, confirms that the giant bandgap lowering observed in GaP1-xNx results from a CBM that evolves purely from nitrogen impurity bands

Alterações na porosidade, na densidade e na condutividade hidráulica de um Gleissolo Háplico sob arroz irrigado por inundação.

O objetivo deste trabalho foi avaliar a alteração da porosidade, da densidade e da condutividade hidráulica de um Gleissolo Háplico cultivado com arroz irrigado por inundação em sistema convencional. O estudo foi conduzido na Estação Experimental da Fazenda Palmital da Embrapa Arroz e Feijão, localizada no município de Goianira, GO, 16° 43? 33? S, 49° 38? 33? W e 785 metros de altitude média

Larotrectinib efficacy and safety in TRK fusion cancer: An expanded clinical dataset showing consistency in an age and tumor agnostic approach

Background: TRK fusion cancer results from gene fusions involving NTRK1, NTRK2 or NTRK3. Larotrectinib, the first selective TRK inhibitor, has demonstrated an overall response rate (ORR) of 75% with a favorable safety profile in the first 55 consecutively enrolled adult and pediatric patients with TRK fusion cancer (Drilon et al.,NEJM2018). Here, we report the clinical activity of larotrectinib in an additional 35 TRK fusion cancer patients and provide updated follow-up of the primary analysis set (PAS) of 55 patients as of 19thFeb 2018. Methods: Patients with TRK fusion cancer detected by molecular profiling from 3 larotrectinib clinical trials (NCT02122913, NCT02637687, and NCT02576431) were eligible.Larotrectinib was administered until disease progression, withdrawal, or unacceptable toxicity. Disease status was assessed using RECIST version 1.1. Results: As of Feb 2018, by independent review, 6 PRs in the PAS deepened to CRs. The median duration of response (DoR) and progression-free survival in the PAS had still not been reached, with 12.9 months median follow-up. At 1 year, 69% of responses were ongoing, 58% of patients remained progression-free and 90% of patients were alive. An additional 19 children and 25 adults (age range, 0.1-78 years) with TRK fusion cancer were enrolled after the PAS, and included cancers of the salivary gland, thyroid, lung, colon, melanoma, sarcoma, GIST and congenital mesoblastic nephroma. In 35 evaluable patients, the ORR by investigator assessment was 74% (5 CR, 21 PR, 6 SD, 2 PD, 1 not determined). In these patients, with median follow-up of 5.5 months, median DoR had not yet been reached, and 88% of responses were ongoing at 6 months, consistent with the PAS. Adverse events (AEs) were predominantly grade 1, with dizziness, increased AST/ALT, fatigue, nausea and constipation the most common AEs reported in ≥ 10% of patients. No AE of grade 3 or 4 related to larotrectinib occurred in more than 5% of patients. Conclusions: TRK fusions are detected in a broad range of tumor types. Larotrectinib is an effective age- and tumor-agnostic treatment for TRK fusion cancer with a positive safety profile. Screening patients for NTRK gene fusions in solid- and brain tumors should be actively considered

Could biochar and green manure be a substitute for synthetic nitrogen fertilization to guarantee rice grain yield and decrease greenhouse gas emissions?

The objective of this study was to find a feasible alternative to the use of nitrogen fertilizers for smallholders and commercial farming in tropical flooded rice systems

Three-Dimensional Engineered Bone–Ligament–Bone Constructs for Anterior Cruciate Ligament Replacement

The anterior cruciate ligament (ACL), a major stabilizer of the knee, is commonly injured. Because of its intrinsic poor healing ability, a torn ACL is usually reconstructed by a graft. We developed a multi-phasic, or bone?ligament?bone, tissue-engineered construct for ACL grafts using bone marrow stromal cells and sheep as a model system. After 6 months in vivo, the constructs increased in cross section and exhibited a well-organized microstructure, native bone integration, a functional enthesis, vascularization, innervation, increased collagen content, and structural alignment. The constructs increased in stiffness to 52% of the tangent modulus and 95% of the geometric stiffness of native ACL. The viscoelastic response of the explants was virtually indistinguishable from that of adult ACL. These results suggest that our constructs after implantation can obtain physiologically relevant structural and functional characteristics comparable to those of adult ACL. They present a viable option for ACL replacement.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98477/1/ten%2Etea%2E2011%2E0231.pd