Influence of Indentation on the Critical Current of Nb3Sn Strands

AbstractThe Japan Atomic Energy Agency (JAEA) is procuring Central Solenoid (CS) conductorsfor all modules forITER. The superconducting properties of the Nb3Sn CS conductors will have to sustain 60,000 electromagnetic (EM) cycles. The current sharing temperatures (Tcs) were stable with EM cycles in short twist pitch conductors.However, the short twist pitch and tight cabling increases indented strands at the contact point between strands before heat treatment. The results of Ic measurement on artificially indented Nb3Sn strands indicate that Ic was almost constant within a critical depth of the indentations

Vaccine Based on Dendritic Cells Electroporated with an Exogenous Ovalbumin Protein and Pulsed with Invariant Natural Killer T Cell Ligands Effectively Induces Antigen-Specific Antitumor Immunity

(1) Background: Cancer vaccines are administered to induce cytotoxic CD8+ T cells (CTLs) specific for tumor antigens. Invariant natural killer T (iNKT) cells, the specific T cells activated by α-galactosylceramide (α-GalCer), play important roles in this process as they are involved in both innate and adaptive immunity. We developed a new cancer vaccine strategy in which dendritic cells (DCs) were loaded with an exogenous ovalbumin (OVA) protein by electroporation (EP) and pulsed with α-GalCer. (2) Methods: We generated bone marrow-derived DCs from C57BL/6 mice, loaded full-length ovalbumin proteins to the DCs by EP, and pulsed them with α-GalCer (OVA-EP-galDCs). The OVA-EP-galDCs were intravenously administered to C57BL/6 mice as a vaccine. We then investigated subsequent immune responses, such as the induction of iNKT cells, NK cells, intrinsic DCs, and OVA-specific CD8+ T cells, including tissue-resident memory T (TRM) cells. (3) Results: The OVA-EP-galDC vaccine efficiently rejected subcutaneous tumors in a manner primarily dependent on CD8+ T cells. In addition to the OVA-specific CD8+ T cells both in early and late phases, we observed the induction of antigen-specific TRM cells in the skin. (4) Conclusions: The OVA-EP-galDC vaccine efficiently induced antigen-specific antitumor immunity, which was sustained over time, as shown by the TRM cells

Reduced Number and Immune Dysfunction of CD4+ T Cells in Obesity Accelerate Colorectal Cancer Progression

Obesity, a known risk factor for various types of cancer, reduces the number and function of cytotoxic immune cells in the tumor immune microenvironment (TIME). However, the impact of obesity on CD4+ T cells remains unclear. Therefore, this study aimed to clarify the impact of obesity on CD4+ T cells in the TIME. A tumor-bearing obese mouse model was established by feeding with 45% high-fat diet (HFD), followed by inoculation with a colon cancer cell line MC38. Tumor growth was significantly accelerated compared to that in mice fed a control diet. Tumor CD4+ T cells showed a significant reduction in number and an increased expression of programmed death-1 (PD-1), and decreased CD107a expression and cytokine such as IFN-γ and TNF-α production, indicating dysfunction. We further established CD4+ T cell-depleted HFD-fed model mice, which showed reduced tumor infiltration, increased PD-1 expression in CD8+ T cells, and obesity-induced acceleration of tumor growth in a CD4+ T cell-dependent manner. These findings suggest that the reduced number and dysfunction of CD4+ T cells due to obesity led to a decreased anti-tumor response of both CD4+ and CD8+ T cells to ultimately accelerate the progression of colorectal cancer. Our findings may elucidate the pathogenesis for poor outcomes of colorectal cancer associated with obesity

Performance Analysis of Mass-Produced Nb3Sn Conductor for Central Solenoid in ITER

The performance of two mass-produced Nb3Sn conductors for the ITER central solenoids was tested for the first timmass-produced Nb3Sn conductorse. One was cut from the forward end of an 80-m-long conductor, and the other was cut from the forward end of a 918-m-long conductor. The fifth-stage twist pitches of these conductors were lengthened by approximately 16% during cable insertion and compaction with conduit. The current sharing temperatures Tcs were measured over 20 000 electromagnetic cycles, including four thermal cycles between 4.2 K and room temperature. The Tcs of the former conductor increased and became almost constant through the cycling. In contrast, Tcs of the latter conductor not only increased but also decreased slightly against cycling. The Tcs decline rate after 10002 cycles was -4.50 × 10-6 K/cycle. If this rate is assumed to continue after 20000 cycles, Tcs would decrease by -0.27 K over 60000 cycles. Even so, Tcs is higher than an acceptance criterion of 6.5 K at 60 000 cycles. The ac losses Q of both conductors at a current of 0 kA were almost the same as or slightly lower than Q of a short sample conductor whose fifth-stage twist pitch was not lengthen. On each conductor, Q at 40 kA was approximately 10% higher than that at 0 kA; thus, the effect of the transport current on Q was not large

Analysis of Internal-Tin Nb3Sn Conductors for ITER Central Solenoid

Japan Atomic Energy Agency (JAEA) is procuring 100% of the ITER Central Solenoid (CS) conductors. The CS conductor is required to maintain the performance under 60000 pulsed electromagnetic cycles. JAEA tested two internal-tin Nb3Sn conductors for the CS at the SULTAN test facility. As a result of destructive examination, the twist pitches of both of the cables satisfied requirements of the ITER Organization (IO). The current sharing temperatures Tcs of each sample were 6.6 and 6.8 K before cyclic operation, and the Tcs values were 6.8 and 6.9 K after 9700 electromagnetic cycles, including three warm-up/cooldowns, respectively. The Tcs performance of both samples satisfied the IO requirement. The ac losses of CSKO1-C and CSKO1-D were approximately half of typical bronze-route CS conductors at 2 and 9 T. The ac loss at 45.1 kA after the cycling was 1.5 times higher than that without the transport current. An almost constant strain of the jacket was observed after the test as a result of the residual strain measurement. Therefore, the deformation of the cable might have been homogeneous along the conductor axis. Because of the higher Tcs of CSKO1-D than CSKO1-C, JAEA started the manufacturing of the CS conductor with the same specification as CSKO1-D