AKARI IRC 2.5-5 um Spectroscopy of Infrared Galaxies over a Wide Luminosity Range

We present the result of a systematic infrared 2.5-5 um spectroscopic study of 22 nearby infrared galaxies over a wide infrared luminosity range (10 < log(L_IR / Lsun) < 13) obtained from AKARI Infrared Camera (IRC). The unique band of the AKARI IRC spectroscopy enables us to access both the 3.3 um polycyclic aromatic hydrocarbon (PAH) emission feature from star forming activity and the continuum of torus-dust emission heated by an active galactic nucleus (AGN). Applying our AGN diagnostics to the AKARI spectra, we discover 14 buried AGNs. The large fraction of buried AGNs suggests that AGN activity behind the dust is almost ubiquitous in ultra-/luminous infrared galaxies (U/LIRGs). We also find that both the fraction and energy contribution of buried AGNs increase with infrared luminosity from 10 < log(L_IR / Lsun) < 13, including normal infrared galaxies with log (L_IR / Lsun) < 11. The energy contribution from AGNs in the total infrared luminosity is only ~7% in LIRGs and ~20% in ULIRGs, suggesting that the majority of the infrared luminosity originates from starburst activity. Using the PAH emission, we investigate the luminosity relation between star formation and AGN. We find that these infrared galaxies exhibit higher star formation rates than optically selected Seyfert galaxies with the same AGN luminosities, implying that infrared galaxies could be an early evolutionary phase of AGN.Comment: 13 pages, 8 figures, accepted for publication in Ap

Copper-deficiency anemia after esophagectomy: A pitfall of postoperative enteral nutrition through jejunostomy

AbstractINTRODUCTIONCopper deficiency leads to functional disorders of hematopoiesis and neurological system. There have been some reports of copper deficiency occurring to the patients on enteral nutrition through a jejunostomy in long-term-care hospitals. However, it is extremely rare to find patients with copper deficiency several months after esophagectomy, regardless of enteral nutrition through the jejunostomy. To the best of our knowledge, this is the first case report of a patient who experienced copper-deficiency anemia after esophagectomy and subsequent enteral nutrition through the jejunostomy.PRESENTATION OF CASEA 73-year-old man presented with pulmonary failure after esophagectomy for esophageal cancer with video-assisted thoracoscopic surgery, and needed long-term artificial ventilator support. Nutritional management included enteral nutrition through a jejunostomy from the early postoperative period. Copper-deficiency anemia was detected 3 months postoperatively; therefore, copper supplementation with cocoa powder was performed, and both serum copper and hemoglobin levels subsequently recovered.DISCUSSIONCopper-deficiency anemia has already been reported to occur in patients receiving enteral nutrition in long-term care hospitals. However, this is the first case report of copper deficiency after esophagectomy despite administration of standard enteral nutrition through the jejunostomy for several months.CONCLUSIONIt is extremely rare to find copper-deficiency anemia several months after esophagectomy followed by enteral nutrition through the jejunostomy. However, if anemia of unknown origin occurs in such patients, copper-deficiency anemia must be considered among the differential diagnoses

Peptidyl prolyl isomerase Pin1-inhibitory activity of d-glutamic and d-aspartic acid derivatives bearing a cyclic aliphatic amine moiety

AbstractPin1 is a peptidyl prolyl isomerase that specifically catalyzes cis–trans isomerization of phosphorylated Thr/Ser-Pro peptide bonds in substrate proteins and peptides. Pin1 is involved in many important cellular processes, including cancer progression, so it is a potential target of cancer therapy. We designed and synthesized a novel series of Pin1 inhibitors based on a glutamic acid or aspartic acid scaffold bearing an aromatic moiety to provide a hydrophobic surface and a cyclic aliphatic amine moiety with affinity for the proline-binding site of Pin1. Glutamic acid derivatives bearing cycloalkylamino and phenylthiazole groups showed potent Pin1-inhibitory activity comparable with that of known inhibitor VER-1. The results indicate that steric interaction of the cyclic alkyl amine moiety with binding site residues plays a key role in enhancing Pin1-inhibitory activity

Investigation of the feasibility of a simple method for verifying the motion of a binary multileaf collimator synchronized with the rotation of the gantry for helical tomotherapy

In this paper, we suggest a new method for verifying the motion of a binary multileaf collimator (MLC) in helical tomotherapy. For this we used a combination of a cylindrical scintillator and a general-purpose camcorder. The camcorder records the light from the scintillator following photon irradiation, which we use to track the motion of the binary MLC. The purpose of this study is to demonstrate the feasibility of this method as a binary MLC quality assurance (QA) tool. First, the verification was performed using a simple binary MLC pattern with a constant leaf open time; secondly, verification using the binary MLC pattern used in a clinical setting was also performed. Sinograms of simple binary MLC patterns, in which leaves that were open were detected as "open" from the measured light, define the sensitivity which, in this case, was 1.000. On the other hand, the specificity, which gives the fraction of closed leaves detected as "closed", was 0.919. The leaf open error identified by our method was -1.3 +/- 7.5%. The 68.6% of observed leaves were performed within +/- 3% relative error. The leaf open error was expressed by the relative errors calculated on the sinogram. In the clinical binary MLC pattern, the sensitivity and specificity were 0.994 and 0.997, respectively. The measurement could be performed with -3.4 +/- 8.0% leaf open error. The 77.5% of observed leaves were performed within +/- 3% relative error. With this method, we can easily verify the motion of the binary MLC, and the measurement unit developed was found to be an effective QA tool.ArticleJOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS. 13(1):27-43 (2012)journal articl

A SCINTIGRAPHIC STUDY OF MASS PERISTALSIS IN HUMAN COLON

Although many attempts have been made to study human colonic motility, the colonic transit is still poorly understood. Both spontaneous and neostigmine-induced peristalsis of the colon were studied with scintigraphy. A polythene tube was inserted into the cecum through a colonofiberscope. 37 MBq of ⁹⁹ᵐTc-DTPA and 75 ml of saline were instilled and dynamic scan was begun. Eight healthy volunteers were examined by the method above mentioned. The sampling time was set at fifteen seconds in six persons and three seconds in the rest. 0.5 mg of neostigmine was injected intravenously to stimulate the paristalsis when no peristalsis occurred within thirty minutes after the study was begun. Dynamic scanning was performed for sixty to ninety minutes. This scintigraphic study revealed that the spontaneous and induced peristalsis were almost identical on colonogram. ⁹⁹ᵐTc-DTPA solution was propelled from the cecum and ascending colon to the sigmoid colon or the rectum for about fifteen seconds during mass peristalsis. Colonogram (time-activity curve) enables us to analyze mass peristalsis easily and more objectively than colonoscintigram. The spontaneous and neostigmine-induced peristalsis seemed to be almost identical in all but one of eight subjects

Systematic infrared 2.5-5 micron spectroscopy of nearby ultraluminous infrared galaxies with AKARI

We report on the results of systematic infrared 2.5-5 micron spectroscopy of 45 nearby ultraluminous infrared galaxies (ULIRGs) at z < 0.3 using IRC onboard the AKARI satellite. This paper investigates whether the luminosities of these ULIRGs are dominated by starburst activity, or optically elusive buried AGNs are energetically important. Our criteria include the strengths of the 3.3 micron polycyclic aromatic hydrocarbon (PAH) emission features and the optical depths of absorption features at 3.1 micron due to ice-covered dust grains and at 3.4 micron from bare carbonaceous dust grains. Because of the AKARI IRC's spectroscopic capability in the full 2.5-5 micron wavelength range, unaffected by Earth's atmosphere, we can apply this energy diagnostic method to ULIRGs at z > 0.15. We estimate the intrinsic luminosities of extended (several kpc), modestly obscured (Av < 15 mag) starburst activity based on the 3.3 micron PAH emission luminosities measured in AKARI IRC slitless spectra, and confirm that such starbursts are energetically unimportant in nearby ULIRGs. In roughly half of the observed ULIRGs classified optically as non-Seyferts, we find signatures of luminous energy sources that produce no PAH emission and/or are more centrally concentrated than the surrounding dust. We interpret these energy sources as buried AGNs. The fraction of ULIRGs with detectable buried AGN signatures increases with increasing infrared luminosity. Our overall results support the scenario that luminous buried AGNs are important in many ULIRGs at z < 0.3 classified optically as non-Seyferts, and that the optical undetectability of such buried AGNs occurs merely because of a large amount of nuclear dust, which can make the sightline of even the lowest dust column density opaque to the ionizing radiation of the AGNs.Comment: 48 pages, 7 figures, accepted for publication in PASJ (AKARI special issue

PHB2 Protects Sister-Chromatid Cohesion in Mitosis

SummaryCohesion between sister chromatids is essential for proper chromosome segregation in mitosis. In vertebrate mitotic cells, most cohesin is removed from the chromosome arms [1–4], but centromeric cohesin is protected by shugoshin until the onset of anaphase [5]. However, the mechanism of this protection of centromeric cohesion is not well understood. Here, we demonstrate that prohibitin 2 (PHB2) is involved in the regulation of sister-chromatid cohesion during mitosis in HeLa cells. PHB2 is an evolutionarily conserved protein in eukaryotes and has multiple functions, such as transcriptional regulation and cell viability and development [6–8]. However, its functions in mitosis have not yet been determined. We show that depletion of PHB2 by RNA interference (RNAi) causes premature sister-chromatid separation and defects in chromosome congression accompanied by mitotic arrest by spindle-checkpoint activation. In the absence of PHB2, cohesin is dissociated from centromeres during early mitosis, although the centromeric localization of shugoshin is preserved. Thus, our findings suggest that, in addition to the shugoshin, PHB2 is also required to protect the centromeric cohesion from phosphorylation by Plk1 during early mitosis and that its function is essential for proper mitotic progression