An Information-Theoretic Approach to Quantitative Analysis of the Correspondence Between Skin Blood Flow and Functional Near-Infrared Spectroscopy Measurement in Prefrontal Cortex Activity

Effect of Skin blood flow (SBF) on functional near-infrared spectroscopy (fNIRS) measurement of cortical activity proves to be an illusive subject matter with divided stances in the neuroscientific literature on its extent. Whereas, some reports on its non-significant influence on fNIRS time series of cortical activity, others consider its impact misleading, even detrimental, in analysis of the brain activity as measured by fNIRS. This situation is further escalated by the fact that almost all analytical studies are based on comparison with functional Magnetic Resonance Imaging (fMRI). In this article, we pinpoint the lack of perspective in previous studies on preservation of information content of resulting fNIRS time series once the SBF is attenuated. In doing so, we propose information-theoretic criteria to quantify the necessary and sufficient conditions for SBF attenuation such that the information content of frontal brain activity in resulting fNIRS times series is preserved. We verify these criteria through evaluation of their utility in comparative analysis of principal component (PCA) and independent component (ICA) SBF attenuation algorithms. Our contributions are 2-fold. First, we show that mere reduction of SBF influence on fNIRS time series of frontal activity is insufficient to warrant preservation of cortical activity information. Second, we empirically justify a higher fidelity of PCA-based algorithm in preservation of the fontal activity's information content in comparison with ICA-based approach. Our results suggest that combination of the first two principal components of PCA-based algorithm results in most efficient SBF attenuation while preserving maximum frontal activity's information. These results contribute to the field by presenting a systematic approach to quantification of the SBF as an interfering process during fNIRS measurement, thereby drawing an informed conclusion on this debate. Furthermore, they provide evidence for a reliable choice among existing SBF attenuation algorithms and their inconclusive number of components, thereby ensuring minimum loss of cortical information during SBF attenuation process

Inhibition of bone erosion, determined by high-resolution peripheral quantitative computed tomography (HR-pQCT), in rheumatoid arthritis patients receiving a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denosumab vs csDMARD therapy alone: an open-label, randomized, parallel-group study

Background: This exploratory study compared the inhibition of bone erosion progression in rheumatoid arthritis (RA) patients treated with a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denosumab versus csDMARD therapy alone and investigated the effects of denosumab on bone micro-architecture and other bone-related parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT).Methods: In this open-label, randomized, parallel-group study, patients with RA undergoing treatment with a csDMARD were randomly assigned (1:1) to continue csDMARD therapy alone or to continue csDMARDs with denosumab (60-mg subcutaneous injection once every 6 months) for 12 months. The primary endpoint was the change from baseline in the depth of bone erosion, measured by HR-pQCT, in the second and third metacarpal heads at 6 months after starting treatment. Exploratory endpoints were also evaluated, and adverse events (AEs) were monitored for safety.Results: In total, 46 patients were enrolled, and 43 were included in the full analysis set (csDMARDs plus denosumab, N = 21; csDMARD therapy alone, N = 22). Most patients were female (88.4%), and the mean age was 65.3 years. The adjusted mean (95% confidence interval) change from baseline in the depth of bone erosion, measured by HR-pQCT, in the 2–3 metacarpal heads at 6 months was − 0.57 mm (− 1.52, 0.39 mm) in the csDMARDs plus denosumab group vs − 0.22 mm (− 0.97, 0.53 mm) in the csDMARD therapy alone group (between-group difference: − 0.35 mm [− 1.00, 0.31]; P = 0.2716). Similar results were shown for the adjusted mean between-group difference in the width and volume of bone erosion of the 2–3 metacarpal heads. Significant improvements in bone micro-architecture parameters were shown. The incidence of AEs and serious AEs was similar between the csDMARDs plus denosumab and the csDMARD therapy alone groups (AEs: 52.2% vs 56.5%; serious AEs: 4.3% vs 8.7%).Conclusions: Although the addition of denosumab to csDMARDs did not find statistically significant improvements in bone erosion after 6 months of treatment, numerical improvements in these parameters suggest that the addition of denosumab to csDMARDs may be effective in inhibiting the progression of bone erosion and improving bone micro-architecture

塩類条件下における果樹の生育に関する比較研究

京都大学0048新制・論文博士博士(農学)乙第10476号論農博第2313号新制||農||810(附属図書館)学位論文||H12||N3450(農学部図書室)UT51-2000-M59(主査)教授 櫻谷 哲夫, 教授 杉浦 明, 教授 小﨑 隆学位規則第4条第2項該当Doctor of Agricultural ScienceKyoto UniversityDA