Development and Congenital Anomalies of the Pancreas

Understanding how the pancreas develops is essential to understand the pathogenesis of congenital pancreatic anomalies. Recent studies have shown the advantages of investigating the development of frogs, mice, and chickens for understanding early embryonic development of the pancreas and congenital anomalies, such as choledochal cysts, anomalous pancreaticobiliary junction, annular pancreas, and pancreas divisum. These anomalies arise from failure of complete rotation and fusion during embryogenesis. There are many theories in the etiology of congenital anomalies of the pancreas. We review pancreas development in humans and other vertebrates. In addition, we attempt to clarify how developmental failure is related to congenital pancreatic anomalies

Inhomogeneous distribution of flux pinning strength and its effecton irreversibility line and vortex glass-liquid transition line in Bi-2212 tapes

The irreversibility line and the vortex glass-liquid transition line under a magnetic field parallel to the c-axis are investigated for silver-sheathed and dip-coated Bi-2212 tape wires. It is found that the two characteristic lines for silver-sheathed tape is well explained by the flux creep-flow model assuming the distribution of pinning strength with a single peak. On the other hand, general agreements are obtained for these characteristic lines and the critical current density between experiments and theory only when two peaks are assumed in the distribution of flux pinning strength for the dip-coated tape. The causative structure in the dip-coated tape for the peak at small strength in the distribution is discusse

Enhancement of developmentally regulated daidzein secretion from soybean roots in field conditions as compared with hydroponic culture

Analyses of metabolite secretions by field-grown plants remain scarce. We analyzed daidzein secretion by field-grown soybean. Daidzein secretion was higher during early vegetative stages than reproductive stages, a trend that was also seen for hydroponically grown soybean. Daidzein secretion was up to 10 000-fold higher under field conditions than hydroponic conditions, leading to a more accurate simulation of rhizosphere daidzein content

Inhomogeneous distribution of flux pinning strength and its effecton irreversibility line and vortex glass-liquid transition line inBi-2212 tapes

The irreversibility line and the vortex glass-liquid transition line under a magnetic field parallel to the c-axis are investigated for silver-sheathed and dip-coated Bi-2212 tape wires. It is found that the two characteristic lines for silver-sheathed tape is well explained by the flux creep-flow model assuming the distribution of pinning strength with a single peak. On the other hand, general agreements are obtained for these characteristic lines and the critical current density between experiments and theory only when two peaks are assumed in the distribution of flux pinning strength for the dip-coated tape. The causative structure in the dip-coated tape for the peak at small strength in the distribution is discusse

Ten-year follow-up of infliximab treatment for uveitis in Behçet disease patients: A multicenter retrospective study

PurposeTo evaluate 10-year outcome of infliximab (IFX) treatment for uveitis in Behçet disease (BD) patients using a standardized follow-up protocol.DesignRetrospective longitudinal cohort study.Participants140 BD uveitis patients treated with IFX enrolled in our previous study.MethodsMedical records were reviewed for demographic information, duration of IFX treatment, number of ocular attacks before IFX initiation, best corrected visual acuity (VA) at baseline and 1, 2, 3, 4, 5, and 10 years after IFX initiation, uveitis recurrence after IFX initiation and main anatomical site, concomitant therapies, and adverse events (AEs).Main outcome measures10-year IFX continuation rate and change in LogMAR VA.ResultsOf 140 BD patients, 106 (75.7%) continued IFX treatment for 10 years. LogMAR VA improved gradually after initiation of IFX, and the improvement reached statistical significance from 2 years of treatment. Thereafter, significant improvement compared with baseline was maintained until 10 years, despite a slight deterioration of logMAR VA from 5 years. However, eyes with worse baseline decimal VA < 0.1 showed no significant improvement from baseline to 10 years. Uveitis recurred after IFX initiation in 50 patients (recurrence group) and did not recur in 56 (non-recurrence group). Ocular attacks/year before IFX initiation was significantly higher in the recurrence group (2.82 ± 3.81) than in the non-recurrence group (1.84 ± 1.78). In the recurrence group, uveitis recurred within 1 year in 58% and within 2 years in 74%. Seventeen patients (34%) had recurrent anterior uveitis, 17 (34%) had posterior uveitis, and 16 (32%) had panuveitis, with no significant difference in VA outcome. In addition, logMAR VA at 10 years did not differ between the recurrence and non-recurrence groups. AEs occurred among 43 patients (30.7%), and 24 (17.1%) resulted in IFX discontinuation before 10 years.ConclusionsAmong BD patients with uveitis who initiated IFX, approximately 75% continued treatment for 10 years, and their VA improved significantly and was maintained for 10 years. Uveitis recurred in one-half of the patients, but visual acuity did not differ significantly from the patients without recurrence