Synthetic Philosophy: A Study Directed toward Creation of an Ideal Synthetic Method and Its Application for Preventing Global Warming by Combating Desertification

金沢大学医薬保健研究域薬学系金沢大学名誉教授This review reports how the author has been realizing his synthetic philosophy and five dreams as his life work. The philosophy consists of such three elements as originality rate, intellectual property factor, and application potential factor. On the basis of these elements, an ideal and an efficient synthesis are defined. In the study for the total synthesis of ergot alkaloids, the first concrete example of an approximately ideal synthesis was demonstrated. Further examples are shown relying on the chemistry of 1-hydroxyindoles. A lot of intellectual properties created by the author are successfully condensed to provide promising lead compounds meeting for the respective dreams of developing five drugs 1) for making desert green and food increase in production, 2) for cardiovascular system disease, 3) for dementia, 4) for lifestyle-related disease (osteoporosis, etc.), and 5) for cancer and virus. With potent promoters of plant\u27s root growth in hand, the first dream is going now successfully. Preliminary experiments combating desertification at Gobi desert in Inner Mongolia are reported in detail, aiming for preventing global warming. © 2008 The Japan Institute of Heterocyclic Chemistry

1-Hydroxyindoles

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学部This review summarizes our hypotheses, syntheses, physical and chemical properties, and chemical reactions of 1-hydroxyindoles. Syntheses of natural products having 1-methoxyindole nucleus and 1-methoxy derivatives of indole alkaloids are also included. Application of the chemistry of 1-hydroxyindoles to the syntheses of biologically active substances, syntheses of tryptophan- 4,5-diones and their reactions, and biological evaluation of 1-hydroxyindoles are reviewed

Indole chemistry for combating yellow sand and desertification directed towards stopping global warming

Various derivatives of indole-3-carbaldehyde are found to be root regulators and they are named SOMRE compounds. Since some of them are potent root promoters and make roots three times longer than usual, their possibilities for increasing food production, combating yellow sand and desertification in Gobi desert, China, were examined. All preliminary experiments are thus far working well. For greening desert and stopping the global warming, it is vital importance to sow seeds to vast area of sand dune all at once. We are now on the stage to scatter seeds, pretreated with SOMRE, to sand dune by airplane. © The Japan Institute of Heterocyclic Chemistry

Ergot alkaloids : the first and five step total syntheses of (-)-and (+)-6,7-secoagroclavines, and syntheses of (-)-and (+)-6-nor-6-propyl-6, 7-secoagroclaines ((-)-and (+)-kstu 1415)

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学