Wino Dark Matter and Future dSph Observations

We discuss the indirect detection of the wino dark matter utilizing gamma-ray observations of dwarf spheroidal galaxies (dSphs). After carefully reviewing current limits with particular attention to astrophysical uncertainties, we show prospects of the wino mass limit in future gamma-ray observation by the Fermi-LAT and the GAMMA-400 telescopes. We find that the improvement of the so-called $J$-factor of both the classical and the ultra-faint dSphs will play a crucial role to cover whole mass range of the wino dark matter. For example, with $\delta (\log_{10}J) = 0.1$ for both the classical and the ultra-faint dSphs, whole wino dark matter mass range can be covered by 15 years and 10 years data at the Fermi-LAT and GAMMA-400 telescopes, respectively.Comment: 32 pages, 13 figure

Antioxidant Activity of Intramolecularly Hydrogen Bonded 2-Aminophenol

The antioxidant activities of five classes of 2-aminophenol (model compound) and 2-aminophenols with substituent at the phenyl ring were studied in the oxidation of tetralin induced by an azo-initiator at 61℃. 2-Aminophenols with electron-donating groups at the 4-position exhibited higher antioxidant activity than that of the model compound. However, introduction of the methoxy group at the 4-position reduced the antioxidant activity by 8 % that of the model compound. 2-Aminophenols with electron-donating groups at the 5-position have little effect on the antioxidant activity. 2-Aminophenols with electron-donating groups at both the 4- and 6-positions showed remarkable antioxidant activity. These results were discussed in terms of the hydrogen bonding effect and bond dissociation energies of the O-H and NH-H bonds

New Bifunctional Antioxidants : In tramolecular Synergistic Effects between Benzofuranol and Thiopropionate Group, Part II

The antioxidant activities of benzofuranols and chromanols with methyl, methyl thiomethyl and thiopropionate groups were evaluated for the oxidation of tetralin at 61 and 140℃. The antioxidants tested showed almost the same behaviour for the oxidation of tetralin initiated by an azo initiator at 61℃. However, benzofuranol and chromanol with a thiopropionate group at the meta position of the OH group were shown to improve antioxidant activity at high temperature to a greater extent than the methyl and methyl thiomethyl groups

Examination of Wireless Power Transfer Combined With the Utilization of Distance Detection

Wireless power transfer using magnetic resonant coupling is expected to be widely used in the charging of an electric vehicle and in the use of home electric appliances. Wireless power transfer requires a high efficiency and power transfer over a long distance. However, the efficiency is reduced by the increase of the transmission distance and the change of the impedance of the receiving load. Therefore, a distance sensor using magnetic resonant coupling is proposed. In this paper, we propose a method of power transfer and distance detection using one couple of coils in real time. We also propose to use different frequencies in the power transfer and the distance detection, which are superposed and separated. Using the proposed approach, we demonstrated that the power transfer and the distance detection can be performed without relying on the change of the transmission distance.ArticleIEEE TRANSACTIONS ON MAGNETICS. 50(11):4005304 (2014)journal articl

LLC resonance power transformers using magnetoplated wire

The use of magneto-plated wire (MPW) allows for reduction of winding loss component from the proximity effect. compared with a copper wire (COW). A MPW is a COW with a circumference that is plated with a magnetic thin film. In this paper, we clarify the basic characteristics and the efficiency characteristics of a transformer using a MPW and a COW. We found that the resistances of a primary coil made of COW and MPW at a frequency f = 500 kHz are 1.56 Omega and 1.12 Omega, respectively, and decreased 28%. The short circuit inductances of the COW and the MPW at a frequency f = 500 kHz are 26 mu H and 29.6 mu H, respectively, and increased 13.8%. The efficiencies of an LLC resonant converter using the COW and the MPW at a frequency f = 500 kHz are 90.2% and 92.2%, respectively, and increased 2%.ArticleINTERNATIONAL JOURNAL OF APPLIED ELECTROMAGNETICS AND MECHANICS. 47(3):719-727 (2015)journal articl

Alpha lipoic acid selectively inhibits proliferation and adhesion to fibronectin of v-H-ras-transformed 3Y1 cells

Here, we focused on the effects of racemic α-lipoic acid on proliferation and adhesion properties of 3Y1 rat fibroblasts and the v-H-ras-transformed derivative, HR-3Y1-2 cells. Racemic α-lipoic acid inhibited proliferation of HR-3Y1-2 but not 3Y1 cells at 0.3 and 1.0 mM. R-(+)-α-lipoic acid also inhibited proliferation of HR-3Y1-2 cells equivalent to that of racemic α-lipoic acid. In addition, racemic α-lipoic acid decreased intracellular reactive oxygen species levels in HR-3Y1 cells but not 3Y1 cells. Next, we evaluated the effects of racemic α-lipoic acid on cell adhesion to fibronectin. The results indicated that racemic α-lipoic acid decreased adhesive ability of HR-3Y1-2 cells to fibronectin-coated plates. As blocking antibody experiment revealed that β1-integrin plays a key role in cell adhesion in this experimental system, the effects of racemic α-lipoic acid on the expression of β1-integrin were examined. The results indicated that racemic α-lipoic acid selectively downregulated the expression of cell surface β1-integrin expression in HR-3Y1-2 cells. Intriguingly, exogenous hydrogen peroxide upregulated cell surface β1-integrin expression in 3Y1 cells. Taken together, these data suggest that reduction of intracellular reactive oxygen species levels by α-lipoic acid could be an effective means of ameliorating abnormal growth and adhesive properties in v-H-ras transformed cells

Activated partial thromboplastin time‑based clot waveform analysis enables measurement of very low levels of factor IX activity in patients with severe hemophilia B

The precise measurement of very low levels of factor IX activity (FIX:C < 1 IU/dL) is essential for understanding clinical severity and risk of inhibitor development in patients with severe hemophilia B (Pw-SHB). However, such measurement sensitivity has not yet been achieved. We aimed to establish a measurement method using clot waveform analysis (CWA). Residual FIX:C by adding anti-FIX monoclonal antibody, FIX:C by adding recombinant (r)FIX to the commercial Pw-SHB plasmas, and FIX:C in our Pw-SHB were determined by CS-2000i™/CS-2400™, followed by analysis of CWA parameters. The presence of anti-FIX antibody in the commercial Pw-SHB plasmas significantly decreased coagulation potential compared to its absence. The addition of rFIX to these innate plasma samples produced significant changes in three parameters upon adding FIX:C at 0.1–1 IU/dL, supporting the presence of trace FIX:C in Pw-SHB. Therefore, appropriate FIX-depleted plasma containing minimum residual FIX:C was chosen from reference curves of FIX:C (0.01–1 IU/dL). Among patients with untreated Pw-SHB, two had FIX:C 0.6–0.7 IU/dL and two had lower than detectable levels using FIX-depleted plasma. One of the latter had detectable trough levels post-rFIX administration. In conclusion, CWA enabled measurement of very low levels of FIX:C using appropriate FIX-deficient plasma.博士（医学）・乙第1528号・令和4年12月22

Timing of therapeutic interventions against infection-triggered encephalopathy syndrome: a scoping review of the pediatric literature

Our goal was to conduct a scoping review of the literature on the treatment of infection-triggered encephalopathy syndrome/acute encephalopathy in children, focusing on treatment targets and treatment initiation timing. We performed literature searches using PubMed for articles reporting treatments of infection-triggered encephalopathy syndrome/acute encephalopathy. We included articles describing specific treatments for acute encephalopathy with control groups. For the purpose of searching new therapies only experimentally tried in the case series, we also included case series studies without control groups in this review, if the studies contained at least two cases with clear treatment goals. Therapies were classified based on their mechanisms of action into brain protection therapy, immunotherapy, and other therapies. We operationally categorized the timing of treatment initiation as T1 (6–12 h), T2 (12–24 h), T3 (24–48 h), and T4 (&gt;48 h) after the onset of seizures and/or impaired consciousness. Thirty articles were included in this review; no randomized control study was found. Eleven retrospective/historical cohort studies and five case–control studies included control groups with or without specific therapies or outcomes. The targeted conditions and treatment timing varied widely across studies. However, the following three points were suggested to be effective in multiple studies: (1) Careful seizure management and targeted temperature management within 12 h (T1) of onset of febrile seizure/prolonged impaired consciousness without multiple organ failure may reduce the development of acute encephalopathy with biphasic seizures and late reduced diffusion; (2) immunotherapy using corticosteroids, tocilizumab, or plasma exchange within 24 h (T1–T2) of onset of acute necrotizing encephalopathy may reduce sequelae; and (3) anakinra therapy and ketogenic diet demonstrate little evidence of neurologic sequelae reduction, but may reduce seizure frequency and allow for weaning from barbiturates, even when administered weeks (T4) after onset in children with febrile infection-related epilepsy syndrome. Although available studies have no solid evidence in the treatment of infection-triggered encephalopathy syndrome/acute encephalopathy, this scoping review lays the groundwork for future prospective clinical trials