2 research outputs found
DISPOSITIVI MICROFLUIDICI PER APPLICAZIONE IN CAMPO BIOMEDICALE, FABBRICATI IN MATERIALE POLIMERICO COMPOSITO
La presente invenzione si riferisce a sistemi e/o dispositivi miniaturizzati di tipo microfluidico, in particolare del tipo denominato con il termine Lab-On-Chip, utilizzati per applicazioni biomedicali e simil
Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma
Abstract
Background: The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis
and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with intensive
nucleolar metabolism as a response to oncogenic factors overexpression. Several members of the Epidermal Growth
Factor Receptor (EGFR) family, have been identifed in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored.
Results: We focused our research on the nucleolar function that a specifc member of EGFR family, the ErbB3 receptor, plays in glioblastoma, a tumor without efective therapies. Here, Neuregulin 1 mediated proliferative stimuli,
promotes ErbB3 relocalization from the nucleolus to the cytoplasm and increases pre-rRNA synthesis. Instead ErbB3
silencing or nucleolar stress reduce cell proliferation and afect cell cycle progression.
Conclusions: These data point to the existence of an ErbB3-mediated non canonical pathway that glioblastoma cells
use to control ribosomes synthesis and cell proliferation. These results highlight the potential role for the nucleolar
ErbB3 receptor, as a new target in glioblastoma