A novel Copper (II) Schiff base complex:synthesis,characterization,and antibacterial activity

The current study focuses on synthesis, characterization and antimicrobial activity of cu (II) with N-(3-nitrobenzylidene)-4-cholorobenzenamine Schiff base ligand. Coordination compound for cu (II) with N-(3n nitrobenzylidene)-4-cholorobenzenamine Schiff base ligand was derived from 3 nitro benzaldehyd an para choloro anilin Ligand and its copper complex were characterized using FT-IR, HNMR and CNMR spectra. Finally, the antimicrobial effect of the complex on E. coli was investigated by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests.FT-IR, HNMR and CNMR spectra showed the success of production new complex. Minimum inhibitory concentration and minimum bactericidal concentration studies showed the enhanced antibacterial effect of new complex on E.coli. The results showed that new complex has numerous antimicrobial effect on E.coli

Synthesis and Crystal Structure of Dibromido{[(2-Pyridyl) methyl](p-ethylphenyl)amine}Zinc

The structure of compound has also been examined crystallographically. It crystallizes in the monoclinic space group P 21/c. The title compound has been synthesized from the reaction of 4-ethyl-N-((pyridin-2-yl) methylene) benzeneamine with ZnBr2 metal salt. It has been characterized by using elemental analysis, MS, IR and UV-Visible spectroscopic techniques

FeMn2O4 nanoparticles coated dual responsive temperature and pH-responsive polymer as a magnetic nano-carrier for controlled delivery of letrozole anti-cancer

Objective(s): For cancer cells, an efficient and selective drug delivery vehicle can remarkably improve therapeutic approaches. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 NPs and their incorporation in a dual temperature and pH-responsive polymer, which can serve as an efficient drug carrier. Materials and Methods: MnFe2O4 NPs were synthesized by chemical co-precipitation technique and coated with tetraethyl orthosilicate (TEOS) and modified with 3-mercaptopropionic acid (MPA). Then, it was used in the reaction medium during the synthesis of a temperature and pH-responsive poly (N-isopropylacrylamide-co-vinyl acetate-co-methacrylic acid). The prepared vehicle was characterized by FESEM, XRD, VSM, and FT-IR. Letrozole was used as a model drug and its loading and release and LCST of the vehicles were evaluated. Results: The results for LCST measurements reveal that the phase transition of polymer occurs at temperatures in the range of 37-40 ºC which is in the range of body conditions. Results for loading efficiency shows that maximum loading occur in about 10 h. The loading % for nano-carrier was lower than plain polymer which was due to lower polymer content in the nano-carrier with the same weight compare to the plain polymer. The results for drug release showed that the release of letrozole in pH 1.2, 5.5 and 7.2 was about 80, 45 and 35% for plain polymer and 81, 56 and 50% for the nano-carrier respectively. Conclusion: The results indicate that the prepared magnetic nano-carrier can be a suitable candidate for site-specific and controlled anti-cancer delivery through oral administration