El Roure Gros: una mirada reflexiva

El projecte educatiu de l'escola és un projecte que posa l'infant al centre de l'acció educativa. Vivim en una societat dinàmica i canviant, els canvis que s'esdevenen en aquesta són ràpids i freqüents. Sabem que transmetre tots els continguts que necessitaran els nostres alumnes per ser ciutadans lliures, crítics i autònoms és impossible dins el marc educatiu. D'una banda, no disposem de prou temps per poder fer una transmissió d'aquests continguts i, d'altra banda, desconeixem quines seran exactament les eines que necessitaran els nostres alumnes d'aquí a deu anys. És una necessitat de l'escola dotar els infants de competències que possibilitin que, en un futur proper, es puguin desenvolupar en una societat que necessitarà ciutadans capaços de ser aprenents actius, ser analítics, ser crítics, ser autònoms i ser lliures. Aquestes necessitats ens porten a plantejar un procés d'aprenentatge basat en competències per a la vida. En el marc social actual es fa més necessari que mai que els ciutadans siguin capaços d'aprendre a aprendre al llarg de la vida.The school's educational project has clear foundations and the center of the educational activity is the child. We live in a dynamic and changing society where changes are fast and frequent. However, transmitting the necessary contents to our children in order to make them free, critical and autonomous citizens is impossible within the educational framework, as too little time is available to do this. Moreover, we do not know for sure what type of knowledge our students will need in 10 years' time. A need therefore exists for the school to provide children with the competences that can enable them in the future to fully develop themselves in a society in which citizens should be active and analytic learners, as well as independent and free. These needs lead us to consider a learning process based on life skills. In the current social context, it appears more important than ever that citizens should be capable of being lifelong learners

Viability, method and device for horticultural crops with brackish and marine water

The method that humanity has adopted to hydrate and thus give life to the plants, imitating the model that was most visible, is the rain. However, the great secret to the contribution of nutrients to the vegetables, the irrigation itself, is on earth, in the groundwater layers and aquifers that hoard and administer the water, keeping every drop of rain and distributing the water through the basins, underground rivers, watering indirectly from the mountain to the sea. The key is in the different circulation velocities of the groundwater because of the nature of the substrates. However, agriculture has taken irrigation from above as we know it and has focused especially on drainage capacity. From this point of view, saline water is not beneficial for irrigated agriculture, but may be the only source of irrigation water in large arid regions, especially in developing countries, where the extreme scarcity of freshwater and the rapidly growing population require more water. When considering the possibility of watering with seawater without desalinating, always by means of capillarity systems, it is essential to take into consideration the different strata of soils, the distance to the groundwater, the composition of seawater, the capacity of drainage, chemical reactions of the soil with salts, etc. The modification of any of these parameters can produce effects of salinization, loss of humidity or desertification among others. This study presents the accumulated experience through the joint collaboration between the Centre for Research in Security and food Control of the Polytechnic University of Catalonia (CRESCA) and the Aqua Maris Foundation in capillary irrigation and it proposes a system and device that allows the controlled development of different vegetal species using brackish and seawaterPostprint (published version

A Phase I-II multicenter trial with Avelumab plus autologous dendritic cell vaccine in pre-treated mismatch repair-proficient (MSS) metastatic colorectal cancer patients; GEMCAD 1602 study

[Background]: Immune check-point blockade (ICB) has shown clinical beneft in mismatch repair-defcient/microsatellite instability high metastatic colorectal cancer (mCRC) but not in mismatch repair-profcient/microsatellite stable patients. Cancer vaccines with autologous dendritic cells (ADC) could be a complementary therapeutic approach to ICB as this combination has the potential to achieve synergistic efects. [Methods]: This was a Phase I/II multicentric study with translational sub-studies, to evaluate the safety, pharmacodynamics and anti-tumor efects of Avelumab plus ADC vaccine in heavily pre-treated MSS mCRC patients. Primary objective was to determine the maximum tolerated dose and the efcacy of the combination. The primary end-point was 40% progressionfree survival at 6 months with a 2 Simon Stage. [Results]: A total of 28 patients were screened and 19 pts were included. Combined therapy was safe and well tolerated. An interim analysis (Simon design frst-stage) recommended early termination because only 2/19 (11%) patients were disease free at 6 months. Median PFS was 3.1 months [2.1–5.3 months] and overall survival was 12.2 months [3.2–23.2 months]. Stimulation of immune system was observed in vitro but not clinically. The evaluation of basal RNA-seq noted signifcant changes between pre and post-therapy liver biopsies related to lipid metabolism and transport, infammation and oxidative stress pathways. [Conclusions]: The combination of Avelumab plus ADC vaccine is safe and well tolerated but exhibited modest clinical activity. Our study describes, for the frst-time, a de novo post-therapy metabolic rewiring, that could represent novel immunotherapyinduced tumor vulnerabilities.The study was funded by grants from the FIS PI17/00732 from Instituto de Salud Carlos III, Premi Fi de Residència Emili Letang from Hospital Clínic Barcelona, Plan Nacional de I + D (PID-107139RB-C21 to DB-R and PID2020-115051RB-I00 to MC) and Grupo Español Multidisciplinar en Cáncer Digestivo (GEMCAD). The study was funded with Grants from Catalan Agency for Management of University and Research Grants (AGAUR) (2014-SGR-474, 2017-SGR-1174 and 2017-SGR-1033), Fundació la Marató de TV3 (201330.10), Instituto de Salud Carlos III (PI13/01728 and PI19/00740) and Fundacion Olga Torres (Modalitat A. 2019/2020) to JM. IMMETCOLS signature is under patent protection (EP21382772.8.) This research was financially supported by GEMCAD and (OR Avelumab was provided) by Merck, S.L.U., Madrid, Spain, an affiliate of Merck KGaA, Darmstadt, Germany, as part of an alliance between the healthcare business of Merck KGaA, Darmstadt, Germany (CrossRef Funder ID: https://doi.org/10.13039/100009945) and Pfizer

Experiències entrecreuades a Santa Eugènia del Congost

Rastres de memòria no escrita. D’experiències entrecreuades a Santa Eugènia del Congost... és el primer d’una sèrie de quaderns de treball amb mostres de material visual recollit en el marc del projecte artístic i didàctic Experiències entrecreuades a Santa Eugènia del Congost, desenvolupat en el context de l’antiga font i safareigs de Santa Eugènia del Congost –situats prop de l’autovia C-17, el riu Congost i de l’Ajuntament de Tagamanent–. Des del curs acadèmic 2016-2017, el Grup d’Innovació Docent Consolidat de la Universitat de Barcelona ATESI (Art, Territori, Estratègia Docent, Sostenibilitat i Intervenció Social – GINDC-UB/162) promou accions –instal·lacions artístiques efímeres, performance, tallers oberts, exposicions i actes...– per tal de «reviure» de forma física i conceptual aquests espais en desús per a la població, tot fent èmfasi en la recuperació de la seva memòria històrica, i amb una metodologia que busca integrar l’actuació conjunta d’administracions, figures expertes, centres educatius i ciutadanes. Aquestes accions, ideològicament posicionades, parteixen del treball en règim d’Aprenentatge Servei (ApS), una metodologia docent que implica l’assoliment de competències educatives en la realització d’activitats que tenen un retorn directe en la comunitat. En aquesta línia, les actuacions dutes a terme que es mostren en aquest quadern han tingut la participació d’alumnat del Grau en Belles Arts de la Universitat de Barcelona, de l’Escola Sagrats Cors de Centelles, de l’Escola d’Art i Superior de Disseny de Vic i d’ex-alumnes del mateix centre (EXARTVIC), coordinat per professorat dels diferents àmbits i amb la participació del Grup ApS(UB)

Desplegament de recursos en línea per a l’avaluació i l’autoaprenentage dels alumnes, i foment de l’especialització i competències transversals en el màster MERIT

El projecte es desenvolupa en el marc de la titulació oficial de màster MERIT del Departament de Teoria del Senyal i Comunicacions. El màster, orientat a la recerca i integrat dins del programa Erasmus Mundus, presenta trets esfecífics donat l’origen variat dels estudiants i que s’imparteix integrament en anglès. El projecte s’articula en 4 eixos: Eix 1: Creació d’un Dipòsit de Recursos Docents (DRD) en xarxa (on-line) amb eines d’autoestudi, autodiagnosi i avaluació remota destinades als estudiants de les assignatures CONCENTRATION del Màster. Els objectes d’aprenentatge integren teoria, demostradors interactius i exercicis d’avaluació. Eix 2: Creació d’un sistema de suport al professorat basat en la participació d’estudiants avantatjats de segon curs del Màster, que ajudin a fer un seguiment més personalitzat dels alumnes amb necessitats específiques.Eix 3: Impartició de l’assignatura transversal en anglès “Critical Thinking & Scientific Writing” (3 ECTS), integrada en el MERIT Eix 4: Creació d’un Comité Extern (CE) format per membres destacats d’empreses del sector de les TIC que assessorarà la Comissió de Postgrau (CP) del Departament en la concreció d’itineraris d’especialització dins del màster MERITPeer Reviewe

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

Nutrición parenteral domiciliaria en España 2018. Informe del Grupo de Nutrición Artificial Domiciliaria y Ambulatoria NADYA

Aim: to communicate home parenteral nutrition (HPN) data obtained from the HPN registry of the NADYA-SENPE group (www.nadya-senpe. com) for the year 2018. Material and methods: descriptive analysis of the data collected from adult and pediatric patients with HPN in the NADYA-SENPE group registry from January 1st, 2018 to December 31st, 2018. Results: there were 278 patients from 45 Spanish hospitals (54.7 % women), 23 children and 255 adults, which represent a prevalence rate of 5.95 patients/million inhabitants/year 2018. The most frequent diagnosis in adults was " palliative cancer" (22.0 %), followed by "others". In children it was Hirschsprung's disease together with necrotizing enterocolitis, with four cases (17.4 %). The first indication was short bowel syndrome in both children (60.9 %) and adults (35.7 %). The most frequently used type of catheter was tunneled in both children (81.0 %) and adults (41.1 %). Ending 75 episodes, the most frequent cause was death (52.0 %) and change to oral feeding (33.3 %). Conclusions: the number of centers and collaborating professionals in the registry of patients receiving HPN remains stable, as well as the main indications and reasons for termination of HPN

Viabilidad de la Introducción al mercado y diseño de un sistema de riego de cultivos con agua de mar

El objeto de este proyecto es la realización del estudio de la viabilidad de la introducción al mercado de un sistema de riego de cultivos con Agua de Mar (AM), asimismo se ha realizado el diseño de dicho sistema. Para alcanzar la determinación de la viabilidad del este servicio, primero se lleva a cabo una investigación profundizada sobre la idea del sistema de riego de cultivos con AM que se está desarrollando en la Fundación Aqua Maris de Badalona. Una vez conocida la idea, se ejecuta y perfecciona el diseño del sistema de riego. Este sistema lleva incluido un producto que se debe diseñar con detalle, se trata de unos dispositivos de riego especiales que se emplearán como macetas. Seguidamente, se realiza un plan de negocio con la intención de iniciar una actividad empresarial. Este plan de negocio incluye el análisis de mercado, plan de marketing, plan de operaciones, plan de organización y RRHH, plan económico y financiero, estudio jurídico/legal/fiscal y el plan de contingencias. En último lugar se consigue llegar a la verificación de la viabilidad del servicio, así como realizar el estudio de su impacto ambiental

Viabilidad de la Introducción al mercado y diseño de un sistema de riego de cultivos con agua de mar

El objeto de este proyecto es la realización del estudio de la viabilidad de la introducción al mercado de un sistema de riego de cultivos con Agua de Mar (AM), asimismo se ha realizado el diseño de dicho sistema. Para alcanzar la determinación de la viabilidad del este servicio, primero se lleva a cabo una investigación profundizada sobre la idea del sistema de riego de cultivos con AM que se está desarrollando en la Fundación Aqua Maris de Badalona. Una vez conocida la idea, se ejecuta y perfecciona el diseño del sistema de riego. Este sistema lleva incluido un producto que se debe diseñar con detalle, se trata de unos dispositivos de riego especiales que se emplearán como macetas. Seguidamente, se realiza un plan de negocio con la intención de iniciar una actividad empresarial. Este plan de negocio incluye el análisis de mercado, plan de marketing, plan de operaciones, plan de organización y RRHH, plan económico y financiero, estudio jurídico/legal/fiscal y el plan de contingencias. En último lugar se consigue llegar a la verificación de la viabilidad del servicio, así como realizar el estudio de su impacto ambiental