Production of Z^0 bosons with rapidity gaps: exclusive photoproduction in gamma p and p p collisions and inclusive double diffractive Z^0's

We extend the k_\perp-factorization formalism for exclusive photoproduction of vector mesons to the production of electroweak Z^0 bosons. Predictions for the gamma p \to Z^0 p and p p \to p p Z^0 reactions are given using an unintegrated gluon distribution tested against deep inelastic data. We present distributions in the Z^0 rapidity, transverse momentum of Z^0 as well as in relative azimuthal angle between outgoing protons. The contributions of different flavours are discussed. Absorption effects lower the cross section by a factor of 1.5-2, depending on the Z-boson rapidity. We also discuss the production of Z^0 bosons in central inclusive production. Here rapidity and (x_{\Pom,1}, x_{\Pom,2}) distributions of Z^0 are calculated. The corresponding cross section is about three orders of magnitude larger than that for the purely exclusive process.Comment: 19 pages, 14 figs, A. Cisek is married name of A. Rybarsk

The main features of phraseological units in the Russian and Armenian languages and their translation

The study deals with the structure of phraseological units of the Russian and Armenian languages. The researchers analyze figurative meaning of phraseological units appearing on the base of primary, nominative meaning of the words in one or another free phras

Tuning of Alternative Splicing - Switch From Proto-Oncogene to Tumor Suppressor

STAT5B, a specific member of the STAT family, is intimately associated with prostate tumor progression. While the full form of STAT5B is thought to promote tumor progression, a naturally occurring truncated isoform acts as a tumor suppressor. We previously demonstrated that truncated STAT5 is generated by insertion of an alternatively spliced exon and results in the introduction of an early termination codon. Present approaches targeting STAT proteins based on inhibition of functional domains of STAT\u27s, such as DNA-binding, cooperative binding (protein-protein interaction), dimerization and phosphorylation will halt the action of the entire gene, both the proto-oncogenic and tumor suppressor functions of Stat5B. In this report we develop a new approach aimed at inhibiting the expression of full-length STAT5B (a proto-oncogene) while simultaneously enhancing the expression of STAT5∆B (a tumor suppressor). We have demonstrated the feasibility of using steric-blocking splice-switching oligonucleotides (SSOs) with a complimentary sequence to the targeted exon-intron boundary to enhance alternative intron/exon retention (up to 10%). The functional effect of the intron/exon proportional tuning was validated by cell proliferation and clonogenic assays. The new scheme applies specific steric-blocking splice-switching oligonucleotides and opens an opportunity for anti-tumor treatment as well as for the alteration of functional abilities of other STAT proteins

Tuning of alternative splicing - switch from proto-oncogene to tumor suppressor

STAT5B, a specific member of the ST AT family, is intimately associated with prostate tumor progression. While the full form of STAT5B is thought to promote tumor progression, a naturally occurring truncated isoform acts as a tumor suppressor. We previously demonstrated that truncated STAT5 is generated by insertion of an alternatively spliced exon and results in the introduction of an early termination codon. Present approaches targeting ST AT proteins based on inhibition of functional domains of STAT\u27s, such as DNA-binding, cooperative binding (protein-protein interaction), dimerization and phosphorylation will halt the action of the entire gene, both the proto-oncogenic and tumor suppressor functions of Stat5B. In this report we develop a new approach aimed at inhibiting the expression of full-length STAT5B (a proto-oncogene) while simultaneously enhancing the expression of STAT5AB (a tumor suppressor). We have demonstrated the feasibility of using steric-blocking splice-switching oligonucleotides (SSOs) with a complimentary sequence to the targeted exon-intron boundary to enhance alternative intron/exon retention (up to 10%). The functional effect of the intron/exon proportional tuning was validated by cell proliferation and clonogenic assays. The new scheme applies specific steric-blocking splice-switching oligonucleotides and opens an opportunity for anti-tumor treatment as well as for the alteration of functional abilities of other ST AT proteins. © Ivyspring International Publisher

Adaptive Heat Engine

A major limitation of many heat engines is that their functioning demands on-line control and/or an external fitting between the environmental parameters (e.g., temperatures of thermal baths) and internal parameters of the engine. We study a model for an adaptive heat engine, where - due to feedback from the functional part - the engine's structure adapts to given thermal baths. Hence, no on-line control and no external fitting are needed. The engine can employ unknown resources; it can also adapt to results of its own functioning that make the bath temperatures closer. We determine resources of adaptation and relate them to the prior information available about the environment. © 2016 American Physical Society

Covid-19 and placenta-associated pregnancy complications: is there any connection?

The objective of this literature review was to establish pathogenetic relationships between COVID-19 and placenta-associated pregnancy complications.Цель проведения литературного обзора – установить патогенетические взаимосвязи между COVID-19 и плаценто-ассоциированными осложнениями беременности

Legal regulation of medical care with the use of telemedical technologies by regulatory acts of the Russian Federation

The purpose of the study was to determine the regulation of relations for the provision of medical care using telemedicine technologies by the regulations of the Russian Federation.Цель исследования – определение регламентации отношений по оказанию медицинской помощи с применением телемедицинских технологий нормативными актами Российской Федерации

The role of pioglitazone in the fight against insulin resistance, atherosclerosis, cardiovascular disease, and non-alcoholic fatty liver disease

Modern strategies for the treatment of type 2 diabetes mellitus involve the use of pathogenetically based approaches aimed at achieving optimal glycemic control and its long-term retention. Timely and rational use of 9 classes of hypoglycemic drugs, including as part of combination therapy, makes it possible to achieve significant success in diabetes therapy. One of the fundamental principles in the treatment of type 2 diabetes mellitus is the effect on insulin resistance. For this purpose, two groups of drugs are used: biguanides and thiazolidinediones (glitazones). The action of glitazones is directly related to an increase in the sensitivity of insulin-dependent tissues to insulin and a pronounced decrease in hyperinsulinemia in patients with type 2 diabetes. Of particular interest are the pathways of insulin signal transduction, the mechanisms of insulin resistance, and the possibilities of pathogenetic therapy with thiazolidinediones. Pioglitazone is currently the only available member of the thiazolidinedione class in the world, allowing to expand the management of diabetes mellitus by reducing insulin resistance in muscle and adipose tissue and glucose production by the liver. Its use can have a number of pleiotropic effects, including on cardiovascular diseases and non-alcoholic fatty liver disease, which expands the priorities for choosing hypoglycemic therapy in patients with type 2 diabetes at various stages of therapy

Feynman scaling violation on baryon spectra in pp collisions at LHC and cosmic ray energies

A significant asymmetry in baryon/antibaryon yields in the central region of high energy collisions is observed when the initial state has non-zero baryon charge. This asymmetry is connected with the possibility of baryon charge diffusion in rapidity space. Such a diffusion should decrease the baryon charge in the fragmentation region and translate into the corresponding decrease of the multiplicity of leading baryons. As a result, a new mechanism for Feynman scaling violation in the fragmentation region is obtained. Another numerically more significant reason for the Feynman scaling violation comes from the fact that the average number of cutted Pomerons increases with initial energy. We present the quantitative predictions of the Quark-Gluon String Model (QGSM) for the Feynman scaling violation at LHC energies and at even higher energies that can be important for cosmic ray physics.Comment: 21 pages, 11 figures, and 1 table. arXiv admin note: substantial text overlap with arXiv:1107.1615, arXiv:1007.320

Quark-Gluon String Model Description of Baryon Production in K^{\pm}N Interactions

The process of baryon production in K p collisions at high energies is considered in the framework of the Quark-Gluon String Model. The contribution of the string-junction mechanism to the strange baryon production is analysed. The results of numerical calculations are in reasonable agreement with the data on inclusive spectra of p, Lambda, bar{Lambda}, and on the bar{Lambda}/Lambda asymmetry. The predictions for Xi and Omega baryons are presented.Comment: 19 pages, 7 figure