The Europeanization of Welfare - The Domestic Impact of Intra-European Social Security

Studies of Europeanization have demonstrated that the impact of European integration differs between Member States and across policies. Although Europeanization research has been expanded and clarified in recent years, we still know relatively little about the factors mediating the national processes of change that thus condition impact. This article examines the impact of European social security integration on national welfare institutions in Denmark and Germany, and it traces the Europeanization process, which may explain the diverging impact of a common input in these two Member States. In order to understand how the same process of integration may cause a diverging impact on national institutions, two sets of mediating factors are examined: firstly, the institutional and "de facto" exposedness to European integration; and, secondly, the national political, administrative and legal responses to integration. It is argued that these intervening variables are decisive for how common European demands are mediated nationally and are likely to explain impact variations referring to the same cause. Copyright 2005 Blackwell Publishing Ltd.

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify sex-specific and early age-at-onset osteoarthritis risk loci. We integrate functional genomics data from primary patient tissues (including articular cartilage, subchondral bone, and osteophytic cartilage) and identify high-confidence effector genes. We provide evidence for genetic correlation with phenotypes related to pain, the main disease symptom, and identify likely causal genes linked to neuronal processes. Our results provide insights into key molecular players in disease processes and highlight attractive drug targets to accelerate translation. © 2021 The Author