LA INFLUENCIA DEL DERECHO INTERNACIONAL DEL TRABAJO EN EL DERECHO LABORAL BRASILEÑO

O trabalho, na acepção da palavra, sempre esteve relacionado à própria existência do ser humano, por muito mais do que a mera subsistência, ele representa, sobretudo, um fator de satisfação e realização pessoal, além de trazer dignidade àquele que o exercita. No desenvolvimento do presente estudo, partiu-se do pressuposto inicial da análise com relação à influência do direito internacional do trabalho no direito do trabalho brasileiro, percorrendo pelos instrumentos previstos no tratamento do direito do trabalho em âmbito nacional e internacional, bem como, seus aspectos jurídicos, sociais e históricos. Além dos direitos trabalhistas previstos na Constituição Federal e na legislação ordinária, principalmente na CLT (Consolidação das Leis do Trabalho), encontram-se outros direitos trabalhistas advindos das convenções da OIT (Organização Internacional do Trabalho). O direito internacional teve papel fundamental nesse desenvolvimento; através da ratificação da Convenção e da Organização Internacional do Trabalho, iniciou-se um efetivo processo, sendo que tais órgãos influenciaram na legislação nacional, tendo seus conceitos, princípios e prerrogativas inseridas na Constituição Federal e em demais leis no sentido de aumentar a proteção ao trabalhador. Isto é um avanço normativo considerável quanto à legislação social laboral, foi a internacionalização das normas trabalhistas que impeliu a uma crescente busca, no plano internacional, de harmonização da proteção do trabalhador. O debate sobre direitos humanos e direitos dos trabalhadores tem aumentado, no Direito Internacional, especialmente, porque se tem pretendido, em alguns fóruns, como a OMC (Organização Mundial do Comércio), por exemplo, vincular os direitos humanos no trabalho às questões de comércio internacional.Work, in the meaning of the word, has always been related to the very existence of human beings, for much more than mere subsistence, it represents, above all, a factor of satisfaction and personal fulfillment, in addition to bringing dignity to those who exercise it. In the development of the present study, the starting point was the initial assumption of the analysis regarding the influence of international labor law on Brazilian labor law, covering the instruments provided for in the treatment of labor law at the national and international level, as well as its aspects legal, social and historical. In addition to the labor rights provided for in the Federal Constitution and ordinary legislation (mainly in the CLT – Consolidation of Labor Laws), there are other labor rights arising from the conventions of the ILO – International Labor Organization. International law played a key role in this development; through the ratification of the Convention and the International Labor Organization, an effective process began, and such bodies influenced national legislation, having their concepts, principles and prerogatives inserted in the Federal Constitution and other laws in the sense of increasing the protection of workers. worker. This is a considerable normative advance in terms of social labor legislation. It was the internationalization of labor standards, which led to a growing search, at the international level, for the harmonization of worker protection. O trabalho, na acepção da palavra, sempre esteve relacionado à própria existência do ser humano, por muito mais do que a mera subsistência, ele representa, sobretudo, um fator de satisfação e realização pessoal, além de trazer dignidade àquele que o exercita. No desenvolvimento do presente estudo, partiu-se do pressuposto inicial da análise com relação à influência do direito internacional do trabalho no direito do trabalho brasileiro, percorrendo pelos instrumentos previstos no tratamento do direito do trabalho em âmbito nacional e internacional, bem como, seus aspectos jurídicos, sociais e históricos. Além dos direitos trabalhistas previstos na Constituição Federal e na legislação ordinária, principalmente na CLT (Consolidação das Leis do Trabalho), encontram-se outros direitos trabalhistas advindos das convenções da OIT (Organização Internacional do Trabalho). O direito internacional teve papel fundamental nesse desenvolvimento; através da ratificação da Convenção e da Organização Internacional do Trabalho, iniciou-se um efetivo processo, sendo que tais órgãos influenciaram na legislação nacional, tendo seus conceitos, princípios e prerrogativas inseridas na Constituição Federal e em demais leis no sentido de aumentar a proteção ao trabalhador. Isto é um avanço normativo considerável quanto à legislação social laboral, foi a internacionalização das normas trabalhistas que impeliu a uma crescente busca, no plano internacional, de harmonização da proteção do trabalhador. O debate sobre direitos humanos e direitos dos trabalhadores tem aumentado, no Direito Internacional, especialmente, porque se tem pretendido, em alguns fóruns, como a OMC (Organização Mundial do Comércio), por exemplo, vincular os direitos humanos no trabalho às questões de comércio internacional.El trabajo, en el sentido de la palabra, siempre ha estado relacionado con la existencia misma del ser humano, pues mucho más que mera subsistencia, representa, sobre todo, un factor de satisfacción y realización personal, además de aportar dignidad a quien lo ejerce. En el desarrollo de este estudio, partimos del supuesto inicial del análisis sobre la influencia del derecho internacional del trabajo en el derecho laboral brasileño, pasando por los instrumentos previstos en el tratamiento del derecho laboral a nivel nacional e internacional, así como sus aspectos legales, sociales e históricos. Además de los derechos laborales previstos en la Constitución Federal y en la legislación ordinaria (principalmente en el CLT – Consolidación de las Leyes Laborales), existen otros derechos laborales derivados de los convenios de la OIT – Organización Internacional del Trabajo. El derecho internacional desempeñó un papel clave en este desarrollo; a través de la ratificación del Convenio y de la Organización Internacional del Trabajo, se inició un proceso efectivo, y estos organismos influyeron en la legislación nacional, insertando sus conceptos, principios y prerrogativas en la Constitución Federal y otras leyes para aumentar la protección del trabajador. Este es un avance normativo considerable en cuanto a la legislación social laboral fue la internacionalización de las normas laborales, lo que llevó a una creciente búsqueda, a nivel internacional, de armonización de la protección de los trabajadores.

IRREGULARIDADES ADMINISTRATIVAS Y PREOCUPACIÓN INTERNACIONAL POR LA LUCHA CONTRA LA CORRUPCIÓN

A corrupção é vista como um problema social e intrinsecamente ligada ao desvio de finalidade por parte de pessoas no poder, que dificulta o desenvolvimento de uma nação, ocasionado por atos que atentam a ética, a moral e a legalidade. Configura-se a improbidade administrativa: apropriação e fraude, ganho pessoal, tráfico de influência, enriquecimento ilícito etc. A improbidade administrativa desvenda não apenas atos de flagrante dolo por parte do servidor público, mas também a incompetência administrativa, que causa prejuízos ao Erário (Lei nº 8.429/1992). O combate às irregularidades administrativas, gênero do qual a corrupção é uma espécie, pode ser fortalecido com a Lei Anticorrupção (Lei nº 12.846/2013), que enquadrou a responsabilidade objetiva por condutas que caracterizam atos lesivos à administração Pública, nacional e estrangeira, exercida por pessoas coletivas e que preenche uma lacuna existente no ordenamento jurídico quando entidades de direito privado cometeram tais atos lesivos sem o envolvimento de um órgão público. Assim, o estudo tem como foco a análise da questão da irregularidade administrativa e a preocupação internacional do combate à corrupção, o impacto dos tratados e convenções internacionais sobre o tema, com foco nos instrumentos concebidos pelo governo, seus aspectos jurídicos, sociais e históricos, bem como sua aplicação e as sanções previstas, e a aplicação do acordo de leniência. Utilizou-se de metodologia explicativa, com a análise qualitativa das informações obtidas com o apoio de variadas pesquisas bibliográficas realizadas a partir de publicações científicas referentes ao tema.Corruption is seen as a social problem and intrinsically linked to the misuse of purpose by people in power, which hinders the development of a nation, caused by acts that undermine ethics, morals and legality. Administrative impropriety is configured: appropriation and fraud, personal gain, influence peddling, illicit enrichment, etc. Administrative impropriety reveals not only acts of flagrant deceit on the part of the public servant, but also administrative incompetence, which causes particular damages to the Treasury (Law nº 8.429/92). The fight against administrative irregularities, a genre of which corruption is a species, can be strengthened with the Anti-Corruption Law (Law No. legal persons and which fills an existing gap in the legal system when private law entities committed such harmful acts without the involvement of a public body. Thus, the study focuses on the analysis of the issue of administrative irregularity and the international concern of combating corruption, the impact of international treaties and conventions on the subject, focusing on the instruments designed by the aforementioned government, its legal, social and historical aspects. , as well as its application and the foreseen sanctions, and the application of the leniency agreement. An explanatory methodology was used, with a qualitative analysis of the information obtained with the support of various bibliographical research carried out from scientific publications related to the subject.A corrupção é vista como um problema social e intrinsecamente ligada ao desvio de finalidade por parte de pessoas no poder, que dificulta o desenvolvimento de uma nação, ocasionado por atos que atentam a ética, a moral e a legalidade. Configura-se a improbidade administrativa: apropriação e fraude, ganho pessoal, tráfico de influência, enriquecimento ilícito etc. A improbidade administrativa desvenda não apenas atos de flagrante dolo por parte do servidor público, mas também a incompetência administrativa, que causa prejuízos ao Erário (Lei nº 8.429/1992). O combate às irregularidades administrativas, gênero do qual a corrupção é uma espécie, pode ser fortalecido com a Lei Anticorrupção (Lei nº 12.846/2013), que enquadrou a responsabilidade objetiva por condutas que caracterizam atos lesivos à administração Pública, nacional e estrangeira, exercida por pessoas coletivas e que preenche uma lacuna existente no ordenamento jurídico quando entidades de direito privado cometeram tais atos lesivos sem o envolvimento de um órgão público. Assim, o estudo tem como foco a análise da questão da irregularidade administrativa e a preocupação internacional do combate à corrupção, o impacto dos tratados e convenções internacionais sobre o tema, com foco nos instrumentos concebidos pelo governo, seus aspectos jurídicos, sociais e históricos, bem como sua aplicação e as sanções previstas, e a aplicação do acordo de leniência. Utilizou-se de metodologia explicativa, com a análise qualitativa das informações obtidas com o apoio de variadas pesquisas bibliográficas realizadas a partir de publicações científicas referentes ao tema.La corrupción es vista como un problema social e intrínsecamente ligada a la desviación del propósito por parte de las personas en el poder, lo que obstaculiza el desarrollo de una nación, causada por actos que socavan la ética, la moral y la legalidad. Se configuran las irregularidades administrativas: apropiación y fraude, beneficio personal, tráfico de influencias, enriquecimiento ilícito, etc. La incorrección administrativa revela no sólo actos de flagrante intención por parte del servidor público, sino también incompetencia administrativa, que causa daños particulares al Tesoro (Ley Nº 8.429/92). La lucha contra las irregularidades administrativas, un género del que la corrupción es una especie, puede fortalecerse con la Ley Anticorrupción (Ley Nº 12.846/2013), que enmarcó la responsabilidad objetiva por conductas que caracterizan actos lesivos para la Administración Pública, nacional y extranjera, ejercidos por personas jurídicas y que llenan un vacío en el sistema legal cuando entidades de derecho privado cometen tales actos lesivos sin la participación de un organismo público. Así, el estudio se centra en el análisis de la cuestión de la irregularidad administrativa y la preocupación internacional de la lucha contra la corrupción, el impacto de los tratados y convenciones internacionales en la materia con un enfoque en los instrumentos diseñados por el mencionado gobierno, sus aspectos jurídicos, sociales e históricos, así como su aplicación y las sanciones previstas, y la aplicación del acuerdo de clemencia. Se utilizó una metodología explicativa, con el análisis cualitativo de la información obtenida con el apoyo de diversas investigaciones bibliográficas

Phase diagram of a probabilistic cellular automaton with three-site interactions

We study a (1+1) dimensional probabilistic cellular automaton that is closely related to the Domany-Kinzel (DKCA), but in which the update of a given site depends on the state of {\it three} sites at the previous time step. Thus, compared with the DKCA, there is an additional parameter, $p_3$, representing the probability for a site to be active at time $t$, given that its nearest neighbors and itself were active at time $t-1$. We study phase transitions and critical behavior for the activity {\it and} for damage spreading, using one- and two-site mean-field approximations, and simulations, for $p_3=0$ and $p_3=1$. We find evidence for a line of tricritical points in the ($p_1, p_2, p_3$) parameter space, obtained using a mean-field approximation at pair level. To construct the phase diagram in simulations we employ the growth-exponent method in an interface representation. For $p_3 =0$, the phase diagram is similar to the DKCA, but the damage spreading transition exhibits a reentrant phase. For $p_3=1$, the growth-exponent method reproduces the two absorbing states, first and second-order phase transitions, bicritical point, and damage spreading transition recently identified by Bagnoli {\it et al.} [Phys. Rev. E{\bf 63}, 046116 (2001)].Comment: 15 pages, 7 figures, submited to PR

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Neotropical freshwater fisheries : A dataset of occurrence and abundance of freshwater fishes in the Neotropics

The Neotropical region hosts 4225 freshwater fish species, ranking first among the world's most diverse regions for freshwater fishes. Our NEOTROPICAL FRESHWATER FISHES data set is the first to produce a large-scale Neotropical freshwater fish inventory, covering the entire Neotropical region from Mexico and the Caribbean in the north to the southern limits in Argentina, Paraguay, Chile, and Uruguay. We compiled 185,787 distribution records, with unique georeferenced coordinates, for the 4225 species, represented by occurrence and abundance data. The number of species for the most numerous orders are as follows: Characiformes (1289), Siluriformes (1384), Cichliformes (354), Cyprinodontiformes (245), and Gymnotiformes (135). The most recorded species was the characid Astyanax fasciatus (4696 records). We registered 116,802 distribution records for native species, compared to 1802 distribution records for nonnative species. The main aim of the NEOTROPICAL FRESHWATER FISHES data set was to make these occurrence and abundance data accessible for international researchers to develop ecological and macroecological studies, from local to regional scales, with focal fish species, families, or orders. We anticipate that the NEOTROPICAL FRESHWATER FISHES data set will be valuable for studies on a wide range of ecological processes, such as trophic cascades, fishery pressure, the effects of habitat loss and fragmentation, and the impacts of species invasion and climate change. There are no copyright restrictions on the data, and please cite this data paper when using the data in publications

Relation of Lipoprotein(a) Levels to Incident Type 2 Diabetes and Modification by Alirocumab Treatment

none1691siOBJECTIVE: In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor. RESEARCH DESIGN AND METHODS: In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute coronary syndrome. Incident diabetes was determined from laboratory, medication, and adverse event data. RESULTS: Among 13,480 patients without diabetes at baseline, 1,324 developed type 2 diabetes over a median 2.7 years. Median baseline lipoprotein(a) was 21.9 mg/dL. With placebo, 10 mg/dL lower baseline lipoprotein(a) was associated with hazard ratio 1.04 (95% CI 1.02-1.06, P < 0.001) for incident type 2 diabetes. Alirocumab reduced lipoprotein(a) by a median 23.2% with greater absolute reductions from higher baseline levels and no overall effect on incident type 2 diabetes (hazard ratio 0.95, 95% CI 0.85-1.05). At low baseline lipoprotein(a) levels, alirocumab tended to reduce incident type 2 diabetes, while at high baseline lipoprotein(a) alirocumab tended to increase incident type 2 diabetes compared with placebo (treatment-baseline lipoprotein(a) interaction P = 0.006). In the alirocumab group, a 10 mg/dL decrease in lipoprotein(a) from baseline was associated with hazard ratio 1.07 (95% CI 1.03-1.12; P = 0.0002) for incident type 2 diabetes. CONCLUSIONS: In patients with acute coronary syndrome, baseline lipoprotein(a) concentration associated inversely with incident type 2 diabetes. Alirocumab had neutral overall effect on incident type 2 diabetes. However, treatment-related reductions in lipoprotein(a), more pronounced from high baseline levels, were associated with increased risk of incident type 2 diabetes. Whether these findings pertain to other therapies that reduce lipoprotein(a) is undetermined.restrictedSchwartz G.G.; Szarek M.; Bittner V.A.; Bhatt D.L.; Diaz R.; Goodman S.G.; Jukema J.W.; Loy M.; Manvelian G.; Pordy R.; White H.D.; Steg P.G. ODYSSEY OUTCOMES Committees and Investigators: Gregory G Schwartz, Philippe Gabriel Steg, Deepak L Bhatt, Vera A Bittner, Rafael Diaz, Shaun G Goodman, Robert A Harrington, J Wouter Jukema, Michael Szarek, Harvey D White, Andreas M Zeiher, Pierluigi Tricoci, Matthew T Roe, Kenneth W Mahaffey, Jay M Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J Sasiela, Jean-François Tamby, Philip E Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilic, Renato D Lopes, Nina N Gotcheva, Juan-Carlos Prieto, Huo Yong, Patricio López-Jaramillo, Ivan Pećin, Zeljko Reiner, Petr Ostadal, Margus Viigimaa, Markku S Nieminen, Vakhtang Chumburidze, Nikolaus Marx, Nicolas Danchin, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung-Fat Tse, Robert Gabor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang-Hyun Kim, Andrejs Erglis, Aleksandras Laucevicius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Sigrun Halvorsen, Roger M Correa Flores, Andrzej Budaj, Joao Morais, Maria Dorobantu, Yuri Karpov, Arsen D Ristic, Terrance Chua, Jan Murin, Zlatko Fras, Anthony J Dalby, José Tuñón, H Asita de Silva, Emil Hagström, Ulf Landmesser, Chern-En Chiang, Piyamitr Sritara, Sema Guneri, Alexander Parkhomenko, Kausik K Ray, Patrick M Moriarty, Robert Vogel, Bernard Chaitman, Sheryl F Kelsey, Anders G Olsson, Jean-Lucien Rouleau, Maarten L Simoons, Karen Alexander, Chiara Meloni, Robert Rosenson, Eric J G Sijbrands, Pierluigi Tricoci, John H Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J Matthew Brennan, Shaun Clifton, Adam D DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin Eapen, Patricia Endsley, Arleen Eppinger, Robert W Harrison, Connie Ng Hess, Mark A Hlatky, Joseph Dedrick Jordan, Joshua W Knowles, Bradley J Kolls, David F Kong, Sergio Leonardi, Linda Lillis, David J Maron, Jill Marcus, Robin Mathews, Rajendra H Mehta, Robert J Mentz, Humberto Graner Moreira, Chetan B Patel, Sabrina Bernardez-Pereira, Lynn Perkins, Thomas J Povsic, Etienne Puymirat, William Schuyler Jones, Bimal R Shah, Matthew W Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean Van Diepen, Matthew D Wilson, Andrew T Yan, Lilia B Schiavi, Marcelo Garrido, Andrés F Alvarisqueta, Sonia A Sassone, Anselmo P Bordonava, Alberto E Alves De Lima, Jorge M Schmidberg, Ernesto A Duronto, Orlando C Caruso, Leonardo P Novaretto, Miguel Angel Hominal, Oscar R Montaña, Alberto Caccavo, Oscar A Gomez Vilamajo, Alberto J Lorenzatti, Luis R Cartasegna, Gustavo A Paterlini, Ignacio J Mackinnon, Guillermo D Caime, Marcos Amuchastegui, Oscar Salomone, Oscar R Codutti, Horacio O Jure, Julio O E Bono, Adrian D Hrabar, Julio A Vallejos, Rodolfo A Ahuad Guerrero, Federico Novoa, Cristian A Patocchi, Cesar J Zaidman, Maria E Giuliano, Ricardo D Dran, Marisa L Vico, Gabriela S Carnero, Pablo N Guzman, Juan C Medrano Allende, Daniela F Garcia Brasca, Miguel H Bustamante Labarta, Sebastian Nani, Eduardo D S Blumberg, Hugo R Colombo, Alberto Liberman, Victorino Fuentealba, Hector L Luciardi, Gabriel D Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana Llois, Jonathon H Waites, Nicholas Collins, Allan Soward, Chris L S Hii, James Shaw, Margaret A Arstall, John Horowitz, Daniel Ninio, James F Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts-Thomson, Owen Raffel, Sam J Lehman, Constantine Aroney, Steven G M Coverdale, Paul J Garrahy, Gregory Starmer, Mark Sader, Patrick A Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, Bruno Pirenne, Attilio Leone, Etienne Hoffer, Mathias C M Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzic, Fahir Barakovic, Zlatko Midzic, Belma Pojskic, Emir Fazlibegovic, Mehmed Kulić, Azra Durak-Nalbantic, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, Jose C Nicolau, Flavio E Giorgeto, Ricardo P Silva, Lilia Nigro Maia, Rafael Rech, Paulo R F Rossi, Maria José A G Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O N de Santos, Fernando Neuenschwander, Luiz C Bodanese, Yorghos L Michalaros, Freddy G Eliaschewitz, Maria H Vidotti, Paulo E Leaes, Roberto V Botelho, Sergio Kaiser, Euler Roberto Fernandes Manenti, Dalton B Precoma, Jose C Moura Jorge, Pedro G Silva, Jose A Silveira, Wladmir Saporito, Jose A Marin-Neto, Gilson S Feitosa, Luiz Eduardo F Ritt, Juliana A de Souza, Fernando Costa, Weimar K S B Souza, Helder J L Reis, Leandro Machado, José Carlos Aidar Ayoub, Georgi V Todorov, Fedya P Nikolov, Elena S Velcheva, Maria L Tzekova, Haralambi O Benov, Stanislav L Petranov, Haralin S Tumbev, Nina S Shehova-Yankova, Dimitar T Markov, Dimitar H Raev, Mihail N Mollov, Kostadin N Kichukov, Katya A Ilieva-Pandeva, Raya Ivanova, Maryana Gospodinov, Valentina M Mincheva, Petar V Lazov, Bojidar I Dimov, Manohara Senaratne, James Stone, Jan Kornder, Stephen Pearce, Danielle Dion, Daniel Savard, Yves Pesant, Amritanshu Pandey, Simon Robinson, Gilbert Gosselin, Saul Vizel, Gordon Hoag, Ronald Bourgeois, Anne Morisset, Eric Sabbah, Bruce Sussex, Simon Kouz, Paul MacDonald, Ariel Diaz, Nicolas Michaud, David Fell, Raymond Leung, Tycho Vuurmans, Christopher Lai, Frank Nigro, Richard Davies, Gustavo Nogareda, Ram Vijayaraghavan, John Ducas, Serge Lepage, Shamir Mehta, James Cha, Robert Dupuis, Peter Fong, Sohrab Lutchmedial, Josep Rodes-Cabau, Hussein Fadlallah, David Cleveland, Thao Huynh, Iqbal Bata, Adnan Hameed, Cristian Pincetti, Sergio Potthoff, Monica Acevedo, Arnoldo Aguirre, Margarita Vejar, Mario Yañez, Guillermo Araneda, Mauricio Fernandez, Luis Perez, Paola Varleta, Fernando Florenzano, Laura Huidobro, Carlos A Raffo, Claudia Olivares, Leonardo Nahuelpan, Humberto Montecinos, Jiyan Chen, Yugang Dong, Weijian Huang, Jianzhong Wang, Shi'An Huang, Zhuhua Yao, Xiang Li, Lan Cui, Wenhua Lin, Yuemin Sun, Jingfeng Wang, Jianping Li, Xuelian Zhang, Hong Zhu, Dandan Chen, Lan Huang, Shaohong Dong, Guohai Su, Biao Xu, Xi Su, Xiaoshu Cheng, Jinxiu Lin, Wenxia Zong, Huanming Li, Yi Feng, Dingli Xu, Xinchun Yang, Yuannan Ke, Xuefeng Lin, Zheng Zhang, Zeqi Zheng, Zhurong Luo, Yundai Chen, Chunhua Ding, Yi Zhong, Yang Zheng, Xiaodong Li, Daoquan Peng, Shuiping Zhao, Ying Li, Xuebo Liu, Meng Wei, Shaowen Liu, Yihua Yu, Baiming Qu, Weihong Jiang, Yujie Zhou, Xingsheng Zhao, Zuyi Yuan, Ying Guo, Xiping Xu, Xubo Shi, Junbo Ge, Guosheng Fu, Feng Bai, Weiyi Fang, Xiling Shou, Xiangjun Yang, Jian'An Wang, Meixiang Xiang, Yingxian Sun, Qinghua Lu, Ruiyan Zhang, Jianhua Zhu, 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Valgimigli Marco, Giovanni Licciardello, Carla Auguadro, Filippo Scalise, Claudio Cuccia, Alessandro Salvioni, Giuseppe Musumeci, Michelle Senni, Paolo Calabrò, Salvatore Novo, Pompilio Faggiano, Marco Metra, Nicoletta B De Cesare, Sergio Berti, Claudio Cavallini, Enrico Puccioni, Marcello Galvani, Maurizio Tespili, Piermarco Piatti, Michela Palvarini, Giuseppe De Luca, Roberto Violini, Alessandro De Leo, Zoran Olivari, Pasquale Perrone Filardi, Maurizio Ferratini, Vittorio Racca, Kazuoki Dai, Yuji Shimatani, Haruo Kamiya, Kenji Ando, Yoshihiro Takeda, Yoshihiro Morino, Yoshiki Hata, Kazuo Kimura, Koichi Kishi, Ichiro Michishita, Hiroki Uehara, Toshinori Higashikata, Atsushi Hirayama, Keiji Hirooka, Yasuji Doi, Satoru Sakagami, Shuichi Taguchi, Akihiro Koike, Hiroyuki Fujinaga, Shinji Koba, Ken Kozuma, Tomohiro Kawasaki, Yujiro Ono, Masatoshi Shimizu, Yousuke Katsuda, Atsuyuki Wada, Toshiro Shinke, Takeshi Kimura, Junya Ako, Kenshi Fujii, Toshiyuki Takahashi, Tomohiro Sakamoto, Koichi 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Marcel J J A Bokern, Remco Nijmeijer, Ferry M R J Hersbach, Frank F Willems, Antonius T M Gosselink, Saman Rasoul, John Elliott, Gerard Wilkins, Raewyn Fisher, Douglas Scott, Hamish Hart, Ralph Stewart, Scott Harding, Ian Ternouth, Nicholas Fisher, Samuel Wilson, Denise Aitken, Russell Anscombe, Laura Davidson, Tadeusz Tomala, Ottar Nygård, Jon Arne Sparby, Kjell Andersen, Lars Gullestad, Jarle Jortveit, Peter S Munk, Erlend Gyllensten Singsaas, Ulf Hurtig, Jorge R Calderon Ticona, Julio R Durand Velasquez, Sandra A Negron Miguel, Enrique S Sanabria Perez, Jesus M Carrion Chambilla, Carlos A Chavez Ayala, Reynaldo P Castillo Leon, Rolando J Vargas Gonzales, Jose D Hernandez Zuniga, Luis A Camacho Cosavalente, Jorge E Bravo Mannucci, Javier Heredia Landeo, Nassip C Llerena Navarro, Yudy M Roldan Concha, Víctor E Rodriguez Chavez, Henry A Anchante Hernandez, Carlos A Zea Nunez, Walter Mogrovejo Ramos, Arthur Ferrolino, Rosa Allyn G Sy, Louie Tirador, Rody G Sy, Generoso Matiga, Raul 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Bengus, Constantin Militaru, Doina Rosu, Irinel R Parepa, Adrian V Matei, Tom M Alexandru, Mihaela Malis, Ioan Coman, Rodica Stanescu-Cioranu, Doina Dimulescu, Yury Shvarts, Olga Orlikova, Zhanna Kobalava, Olga L Barbarash, Valentin Markov, Nadezhda Lyamina, Alexander Gordienko, Konstantin Zrazhevsky, Alexander Y Vishnevsky, Victor Gurevich, Raisa Stryuk, Nikita V Lomakin, Igor Bokarev, Tatiana Khlevchuk, Sergey Shalaev, Larisa Khaisheva, Petr Chizhov, Inna Viktorova, Natalya Osokina, Vladimir Shchekotov, Evgenia Akatova, Galina Chumakova, Igor Libov, Mikhail I Voevoda, Tatyana V Tretyakova, Evgeny Baranov, Sergey Shustov, Sergey Yakushin, Ivan Gordeev, Niiaz Khasanov, Olga Reshetko, Tatiana Sotnikova, Olga Molchanova, Konstantin Nikolaev, Liudmila Gapon, Elena Baranova, Zaur Shogenov, Elena Kosmachova, Yuriy Karpov, Anton Povzun, Liudmila Egorova, Vadim V Tyrenko, Igor G Ivanov, Masterov Ilya, Sergey Kanorsky, Dragan Simic, Nikola Ivanovic, Goran Davidovic, Nebojsa Tasic, Milika R Asanin, Stevo Stojic, Svetlana R Apostolovic, Stevan Ilic, Biljana Putnikovic Tosic, Aleksandar Stankovic, Aleksandra Arandjelovic, Slavica Radovanovic, Branislava Todic, Jovan Balinovac, Dragan V Dincic, Petar Seferovic, Ana Karadzic, Slobodan Dodic, Sinisa Dimkovic, Tamara Jakimov, Kian-Keong Poh, Hean Yee Ong, Justin Tang I-Shing, Karol Micko, Jan Nociar, Daniel Pella, Peter Fulop, Marian Hranai, Juraj Palka, Juraj Mazur, Ivan Majercák, Andrej Dzupina, František Fazekas, Jozef Gonsorcik, Viliam Bugan, Juraj Selecky, Gabriel Kamensky, Jaroslava Strbova, Rudolf Smik, Andrej Dukat, Peter Olexa, Ivan Žuran, Janez Poklukar, Nataša Černič Šuligoj, Matija Cevc, Henry P Cyster, Naresh Ranjith, Clive Corbett, Junaid Bayat, Ellen Makoali Makotoko, Hendrik du Toit Theron, Ilse E Kapp, Matthys M de V Basson, Hanlie Lottering, Dina Van Aswegen, Louis J Van Zyl, Peter J Sebastian, Thayabran Pillay, Jan A Saaiman, Patrick J Commerford, Soraya Cassimjee, Garda Riaz, Iftikhar O Ebrahim, Mahomed Sarvan, Joseph H Mynhardt, Helmuth Reuter, Rajendran Moodley, Manuel Vida, Angel R Cequier Fillat, Vicente Bodí Peris, Francisco Fuentes Jimenez, Francisco Marín, Jose M Cruz Fernández, Rafael Jesus Hidalgo Urbano, Blas Gil-Extremera, Pablo Toledo, Fernando Worner Diz, David Garcia-Dorado, Andres Iñiguez, José Tuñón Fernández, Jose R Gonzalez-Juanatey, Javier Fernandez Portales, Fernando Civeira Murillo, Laia Matas Pericas, Jose Luis Zamorano, Manuel De Mora Martin, Jordi Bruguera Cortada, Joaquin J Alonso Martin, Jose Maria Serrano Antolin, José R De Berrazueta Fernández, José Antonio Vázquez de Prada, Jose Francisco Díaz Fernández, José Alberto García Lledó, Juan Cosín Sal

Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol

International audienceBackground: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk.Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels.Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was 13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43.Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402)