Efecto de la exposición a campos magnéticos estacionarios de 125 mT y 250 mT en la germinación de semillas de guisante

El objetivo principal de este estudio es conocer los efectos que la acción de un campo magnético artificial estacionario tiene sobre la germinación de semillas de guisante. Para ello, se ha determinado y cuantificado el posible aumento en la velocidad germinativa de semillas de guisante que han sido sometidas a la acción de un campo magnético estacionario de 125 mT y 250 mT durante diferentes tiempos de exposición (1 minuto, 10 minutos, 20 minutos, 1 hora, 24 horas y exposición crónica). Los parámetros utilizados han sido: porcentaje de semillas germinadas (Gmáx), tiempo medio de germinación (TMG) y tiempo necesario para que germine el 1, 10, 25, 50, 75 y 90 % de las semillas utilizadas en cada tratamiento (T1, T10, T25, T50, T75 y T90). Del análisis de los datos se puede concluir que la velocidad de germinación de las semillas sometidas a la acción del campo magnético es mayor que la de las semillas no tratadas

Safety Pays for Hispanic Employees, Company Owners, and Extension Professionals Active in Urban Agriculture Industries

The landscape industry and other urban agriculture industries are dangerous, and many of the workers in these industries are Hispanic. The financial, emotional, and social costs of workplace injuries are substantial. Extension personnel, business owners, and all workers benefit when safety trainings are held in Spanish. The impact, benefits, and ease of conducting safety trainings in Spanish for Hispanic workers in urban agriculture industries are discussed

External validity of clinical trials with diverse trastuzumab-based chemotherapy regimens in advanced gastroesophageal adenocarcinoma: data from the AGAMENON-SEOM registry

Quimioteràpia; Càncer gàstric; TrastuzumabQuimioterapia; Cáncer gástrico; TrastuzumabChemotherapy; Gastric cancer; TrastuzumabBackground: Trastuzumab combined with cisplatin and fluoropyrimidines, either capecitabine or 5-fluorouracile (XP/FP), is the standard first-line treatment for advanced, HER2-positive, gastric cancer patients based on the ToGA trial. Despite the lack of phase III trials, many clinicians administer trastuzumab with alternative regimens. One meta-analysis suggests that substituting cisplatin for oxaliplatin might lead to greater efficacy and less toxicity. Methods: 594 patients with HER2-positive gastroesophageal adenocarcinoma were recruited from the AGAMENON-SEOM registry. The objective was to evaluate the external validity of clinical trials with chemotherapy and trastuzumab. Results: The regimens used in at least 5% of the patients were XP (27%), oxaliplatin and capecitabine (CAPOX) (26%), oxaliplatin and 5-fluorouracil (FOLFOX) (14%), FP (14%), triplet with anthracycline/docetaxel (7%), and carboplatin-FU (5%). Median exposure to trastuzumab was longer with FOLFOX (11.4 months, 95% CI, 9.1–21.0) versus ToGA regimens (7.5, 6.4–8.5), p < 0.001. Patients with HER2-IHC 3+ cancers had higher response rates than those with IHC 2+/FISH+, odds-ratio 1.97 (95% CI, 1.25–3.09). The results achieved with CAPOX–trastuzumab were comparable to those attained with ToGA regimens. FOLFOX–trastuzumab was superior to ToGA schemes in terms of overall survival (OS), with a greater magnitude of effect in IHC 2+/FISH+ tumors (HR 0.47, 0.24–0.92) compared with IHC 3+ (HR 0.69, 0.49–0.96), and in diffuse (HR 0.37, 0.20–0.69) versus intestinal-type tumors (HR 0.76, 0.54–1.06). Conclusion: We have updated the external validity of clinical trials with trastuzumab in first-line treatment of gastric cancer. Our data confirm the comparable outcomes of ToGA regimens and CAPOX–trastuzumab in clinical practice and point toward a possible benefit of FOLFOX–trastuzumab, contingent on the subtypes typically less sensitive to trastuzumab, to be confirmed in clinical trials.The authors received no financial support for the research, authorship, and/or publication of this article

Recovery of the MOSFET and circuit functionality after the dielectric breakdown of ultra-thin high-k gate stacks

The reversibility of the gate dielectric breakdown in ultra-thin high-k dielectric stacks is reported and analyzed. The electrical performance of MOSFETs after the dielectric recovery is modeled and introduced in a circuit simulator. The simulation of several digital circuits shows that their functionality can be restored after the BD recovery

Experimental verification of memristor-based material implication NAND operation

Memristors are being considered as promising devices for highly dense memory systems as well as the potential basis of new computational paradigms. In this scenario, and in relation with data processing, one of the more specific and differential logic functions is the material implication logic also named as IMPLY logic. Many papers have been published in this framework but few of them are related with experimental works using real memristor devices. In the paper authors show the verification of the IMPLY function by using Ni/HfO2/Si manufactured devices and laboratory measurements. The proper behavior of the IMPLY structure (2 memristors) has been shown. The paper also verifies the proper operation of a two-step IMPLY-based NAND gate implementation, showing the electrical behavior of the circuit in a cycling operation. A new procedure to implement a NAND gate that requires only one step is experimentally shown as well

Channel-Hot-Carrier degradation of strained MOSFETs : A device level and nanoscale combined approach

Strained MOSFETs with SiGe at the source/drain regions and different channel lengths have been studied at the nanoscale with a conductive atomic force microscope (CAFM) and at device level, before and after channel-hot-carrier (CHC) stress. The results show that although strained devices have a larger mobility, they are more sensitive to CHC stress. This effect has been observed to be larger in short channel devices. The higher susceptibility of strained MOSFETs to the stress has been related to a larger density of defects close to the diffusions, as suggested by CAFM data

Non-homogeneuos conduction of conductive filaments in Ni/HfO2/Si resistive switching structures observed with CAFM

Altres ajuts: ERDF/TEC2011-2792-C02-02Conductive filaments (CFs) in Ni/HfO₂/Si resistive switching structures are analysed at the nanoscale by means of Conductive Atomic Force Microscopy (CAFM). Differences in the CF conductivity are measured depending on the resistive state of the device. Moreover, for both resistance states, non-homogeneous conduction across the CF area is observed, in agreement with a tree-shaped CF

Inter-Individual variability in insulin response after grape pomace supplementation in subjects at high cardiometabolic risk: role of microbiota and miRNA

Scope Dietary polyphenols have shown promising effects in mechanistic and preclinical studies on the regulation of cardiometabolic alterations. Nevertheless, clinical trials have provided contradictory results, with high inter‐individual variability. This study explores the role of gut microbiota and microRNAs (miRNAs) as factors contributing to the inter‐individual variability in polyphenol response. Methods and Results 49 subjects with at least two factors of metabolic syndrome are divided between responders (n = 23) or non‐responders (n = 26), depending on the variation rate in fasting insulin after grape pomace supplementation (6 weeks). The populations of selected fecal bacteria are estimated from fecal deoxyribonucleic acid (DNA) by quantitative real‐time polymerase chain reaction (qPCR), while the microbial‐derived short‐chain fatty acids (SCFAs) are measured in fecal samples by gas chromatography. MicroRNAs are analyzed on a representative sample, followed by targeted miRNA analysis. Responder subjects show significantly lower (p < 0.05) Prevotella and Firmicutes levels, and increased (p < 0.05) miR‐222 levels. Conclusion After evaluating the selected substrates for Prevotella and target genes of miR‐222, these variations suggest that responders are those subjects exhibiting impaired glycaemic control. This study shows that fecal microbiota and miRNA expression may be related to inter‐individual variability in clinical trials with polyphenols