2,018 research outputs found

    The Structure of TGBC_C Phases

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    We study the transition from the cholesteric phase to two TGBC_C phases near the upper critical twist kc2k_{c2}: the Renn-Lubensky TGBC_C phase, with layer normal rotating in a plane perpendicular to the pitch axis, and the Bordeaux TGBC_C phase, with the layer normal rotating on a cone parallel to the pitch axis. We calculate properties, including order-parameter profiles, of both phases.Comment: 4 pages, 4 figures, Submitted to Physical Review E, Rapid Communications, September 5, 2003; Revised manuscript (to the paper submitted on March 18, 2003, cond-mat/0303365)that includes an important missing reference and presents an improved analysis of a generalized mode

    Cell and animal models of SARS-CoV-2 pathogenesis and immunity

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    The spread of the novel virus SARS coronavirus 2 (SARS-CoV-2) was explosive, with cases first identified in December 2019, and >22 million people infected and >775,000 deaths as of August 2020. SARS-CoV-2 can cause severe respiratory disease in humans leading to coronavirus disease 2019 (COVID-19). The development of effective clinical interventions, such as antivirals and vaccines that can limit or even prevent the burden and spread of SARS-CoV-2, is a global health priority. Testing of leading antivirals, monoclonal antibody therapies and vaccines against SARS-CoV-2 will require robust animal and cell models of viral pathogenesis. In this Special Article, we discuss the cell-based and animal models of SARS-CoV-2 infection and pathogenesis that have been described as of August 2020. We also outline the outstanding questions for which researchers can leverage animal and cell-based models to improve our understanding of SARS-CoV-2 pathogenesis and protective immunity. Taken together, the refinement of models of SARS-CoV-2 infection will be critical to guide the development of therapeutics and vaccines against SARS-CoV-2 to end the COVID-19 pandemic

    Boundary Conditions and Quasilocal Energy in the Canonical Formulation of All 1+1 Models of Gravity

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    Within a first-order framework, we comprehensively examine the role played by boundary conditions in the canonical formulation of a completely general two-dimensional gravity model. Our analysis particularly elucidates the perennial themes of mass and energy. The gravity models for which our arguments are valid include theories with dynamical torsion and so-called generalized dilaton theories (GDTs). Our analysis of the canonical action principle (i) provides a rigorous correspondence between the most general first-order two-dimensional Einstein-Cartan model (ECM) and GDT and (ii) allows us to extract in a virtually simultaneous manner the ``true degrees of freedom'' for both ECMs and GDTs. For all such models, the existence of an absolutely conserved (in vacuo) quantity C is a generic feature, with (minus) C corresponding to the black-hole mass parameter in the important special cases of spherically symmetric four-dimensional general relativity and standard two-dimensional dilaton gravity. The mass C also includes (minimally coupled) matter into a ``universal mass function.'' We place particular emphasis on the (quite general) class of models within GDT possessing a Minkowski-like groundstate solution (allowing comparison between CC and the Arnowitt-Deser-Misner mass for such models).Comment: REVTeX, 41 pages, 2 Postscript figures, 10 macro

    Holographic Description of AdS Cosmologies

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    To gain insight in the quantum nature of the big bang, we study the dual field theory description of asymptotically anti-de Sitter solutions of supergravity that have cosmological singularities. The dual theories do not appear to have a stable ground state. One regularization of the theory causes the cosmological singularities in the bulk to turn into giant black holes with scalar hair. We interpret these hairy black holes in the dual field theory and use them to compute a finite temperature effective potential. In our study of the field theory evolution, we find no evidence for a "bounce" from a big crunch to a big bang. Instead, it appears that the big bang is a rare fluctuation from a generic equilibrium quantum gravity state.Comment: 34 pages, 8 figures, v2: minor changes, references adde

    Thermal Giant Graviton with Non-commutative Dipole Field

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    Using the type II near-extremal 3D-branes solution we apply the T-duality and smeared twist to construct the supergravity backgrounds which dual to the 4D finite temperature non-commutative dipole field theories. We first consider the zero-temperature system in which, depending on the property of dipole vectors it may be N=2, N=1 or N=0 theory. We investigate the rotating D3-brane configurations moving on the spactimes and show that, for the cases of N=2 and N =1 the rotating D3-brane could be blowed up to the stable spherical configuration which is called as giant graviton and has a less energy than the point-like graviton. The giant graviton configuration is stable only if its angular momentum was less than a critical value of PcP_c which is an increasing function of the dipole strength. For the case of non-supersymmetric theory, however, the spherical configuration has a larger energy than the point-like graviton. We also find that the dipole field always render the dual giant graviton to be more stable than the point-like graviton. The relation of dual giant graviton energy with its angular momentum, which in the AdS/CFT correspondence being the operator anomalous dimension is obtained. We furthermore show that the temperature does not change the property of the giant graviton, while it will render the dual giant graviton to be unstable.Comment: Latex 20 pages, add comments about BPS bound below (3.8

    Spectra of Coherent Smith-Purcell Radiation Observed from Short Electron Bunches: Numerical and Experimental Studies

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    MOPWA056 - ISBN978-3-95450-122-9International audienceThere is a significant interest in the development of compact particle accelerators within research areas including X-ray and THz (T-ray) sources of radiation, particle physics and medical sciences. To support the progress in these areas, non-invasive, electron beam diagnostics that are capable of measuring a single femtosecond electron bunch are required. At the current stage such beam diagnostics for femtosecond-long electron bunches are still not available. The goal of the work presented is to understand the spectral characteristics of coherent Smith-Purcell radiation to enable its quick and reliable interpretation including the longitudinal profile reconstruction of electron bunches. The research presented comprises results from numerical modelling and experimental studies. Using the numerical data, we discuss the radiated spectra dependence on the electron bunch profile and analyse the results. We also discuss the experimental data and compare it with theoretical predictions

    Utilidad de las técnicas de Giemsa y Warthin Starry para el diagnóstico de gastritis causadas por Helicobacter spp en cerdos.

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    Las gastritis, para el sector productor porcino, continúan siendo una enfermedad subdiagnosticada que no solo trae pérdidas significativas para los productores, sino que también afecta al animal a nivel clínico traduciéndose en pérdida de peso, disminución de la conversión alimenticia y menor cantidad de kilogramos faenados. Esta patología es multifactorial sin embargo la principal causa de gastritis es la bacteria Helicobacter spp. Es una bacteria gram negativa que coloniza la mucosa gástrica produciendo gastritis agudas o crónicas, ulceras, linfoma del MALT, etc. Es importante para el diagnóstico de esta patología contar con técnicas que sean lo suficientemente sensibles y específicas. En estudios anteriores realizados en nuestro laboratorio se reportaron los casos de gastritis crónicas y la relación entre la coloración de Giemsa y la de Warthin Starry (WS), la cual no presento diferencias estadísticamente significativas, siendo indistinta el uso de una u otra para realizar el diagnóstico. El objetivo de este trabajo fue evaluar la sensibilidad y especificidad de las técnicas de Giemsa y WS para diagnosticar la presencia de Helicobacter spp en animales sanos. Se utilizaron 6 estómagos de cerdos diagnosticados como normales con la coloración de H/E. Los mismos fueron sometidos a la técnica de Giemsa y WS para corroborar el diagnóstico. De estos 4 fueron positivos tanto para Giemsa como para WS, 1 resultó negativo para ambas coloraciones y 1 negativo para Giemsa y positivo para WS. Como conclusión podemos estimar que la técnica de WS es sensible, ya que fue capaz de detectar el falso negativo, la especificidad es alta dado que también es capaz de recocer a los negativos como verdaderos negativos. En futuras investigaciones seguiremos indagando acerca de esta temática, planteándonos el interrogante: ¿es Helicobacter spp un habitante normal del estómago de los cerdos o causante de gastritis subclínicas

    Space-time inhomogeneity, anisotropy and gravitational collapse

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    We investigate the evolution of non-adiabatic collapse of a shear-free spherically symmetric stellar configuration with anisotropic stresses accompanied with radial heat flux. The collapse begins from a curvature singularity with infinite mass and size on an inhomogeneous space-time background. The collapse is found to proceed without formation of an even horizon to singularity when the collapsing configuration radiates all its mass energy. The impact of inhomogeneity on various parameters of the collapsing stellar configuration is examined in some specific space-time backgrounds.Comment: To appear in Gen. Relativ. Gra

    Three-Dimensional Gravity with Conformal Scalar and Asymptotic Virasoro Algebra

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    Strominger has derived the Bekenstein-Hawking entropy of the BTZ black hole using asymptotic Virasoro algebra. We apply Strominger's method to a black hole solution found by Martinez and Zanelli (MZ). This is a solution of three-dimensional gravity with a conformal scalar field. The solution is not AdS3AdS_3, but it is asymptotically AdS3AdS_3; therefore, it has the asymptotic Virasoro algebra. We compute the central charge for the theory and compares Cardy's formula with the Bekenstein-Hawking entropy. It turns out that the functional form does agree, but the overall numerical coefficient does not. This is because this approach gives the "maximum possible entropy" for the numerical coefficient.Comment: 26 pages, LaTeX; v2: minor correction
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