Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.49649

Prevalence of codon 72 P53 polymorphism in Brazilian women with cervix cancer

The p53 codon 72 polymorphism seems to be associated with HPV-carcinogenesis, although controversial data have been reported. A series of Brazilian women with cervix carcinomas were analyzed. Ninety-nine (67%) of 148 women were found to be homozygous (arg/arg) for the arginine polymorphism, and 49 (33%) were heterozygous (arg/pro). This polymorphism may be an important determinant of the risk for cervix cancer, but does not seem to be sufficient for carcinogenesis.Hospital Maternidade Leonor Mendes de Barros Oncologia GinecológicaUniversidade Federal de São Paulo (UNIFESP) Laboratório de Ginecologia MolecularUniversidade Estadual de Campinas Faculdade de Medicina Oncologia GinecológicaUniversidade de São Paulo Departamento de Medicina Social Faculdade de Medicina de Ribeirão PretoIstituto Superiore di Sanità Laboratory of Epidemiology and Biostatistics Cytopathology UnitUNIFESP, Laboratório de Ginecologia MolecularSciEL