Highly enantioselective rhodium-catalyzed conjugate addition of arylboronic acids to enones at room temperature

The rhodium–phosphoramidite-catalyzed asymmetric conjugate addition of arylboronic acids to enones proceeds at room temperature using [Rh(OH)(cod)]2 or [RhCl(cod)]2/KOH as stable and readily available catalyst precursors.

Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones

The catalytic asymmetric 1,2-addition of a series of arylboronic acids to 2,2,2-trifluoroacetophenones is described with high isolated yields (up to 96%) and good enantioselectivities (up to 83% ee) using a rhodium(I)/phosphoramidite catalyst.