Distribution of a) global PLI values and b) global wPLI values between subjects at baseline in different frequency bands; all bands are significantly different (see text).

<p>Distribution of a) global PLI values and b) global wPLI values between subjects at baseline in different frequency bands; all bands are significantly different (see text).</p

Test-retest-reliability of global wPLI and wPLI-based graph measures over time by frequency band expressed by the intraclass-correlation coefficient (ICC; CI: confidence interval estimated from bootstrapping; SWI: small-world-index).

<p>Test-retest-reliability of global wPLI and wPLI-based graph measures over time by frequency band expressed by the intraclass-correlation coefficient (ICC; CI: confidence interval estimated from bootstrapping; SWI: small-world-index).</p

Test-retest-reliability of regional PLI over time by frequency band.

<p>The median (range) intraclass-correlation coefficients over 22 regional degrees and 231 inter-regional links are given.</p><p>Test-retest-reliability of regional PLI over time by frequency band.</p

Test-retest-reliability of global PLI and PLI-based graph measures over time by frequency band expressed by the intraclass-correlation coefficient (ICC; CI: confidence interval estimated from bootstrapping; SWI: small-world-index).

<p>Test-retest-reliability of global PLI and PLI-based graph measures over time by frequency band expressed by the intraclass-correlation coefficient (ICC; CI: confidence interval estimated from bootstrapping; SWI: small-world-index).</p

Topographic plots of the grand mean PLI connectomes (green: 3% strongest links are plotted) and grand mean PLI value per electrode (nodal degree, values are color-coded) over all subjects at baseline by frequency band: a) theta, b) alpha1, c) alpha2, d) beta.

<p>Topographic plots of the grand mean PLI connectomes (green: 3% strongest links are plotted) and grand mean PLI value per electrode (nodal degree, values are color-coded) over all subjects at baseline by frequency band: a) theta, b) alpha1, c) alpha2, d) beta.</p

Group and subgroup comparisons: number of significantly different sensors per region, side and frequency band.

<p>Number of sensors with significant differences (p<0.01; in brackets: p<0.05 corrected) between groups (bold) and subgroups (male MS patients vs. healthy men, standard font). Frequency bands: delta: 0.5–4.0 Hz, theta: 4.0–8.0 Hz, lower alpha: 8.0–10.0 Hz, upper alpha: 10.0–13.0 Hz, beta: 13.0–30.0 Hz, gamma: 30.0–48.0 Hz.</p

EC-distribution, group- and subgroup-comparisons and correlations of EC to “cognition” in the beta-band (13–30 Hz).

<p>Regions are plotted in the right upper corner; a) spatial distribution of z-transformed group averaged EC-values per sensor in healthy controls plotted as a z-map; b) group (MS vs. HC) and c) subgroup differences (MS men vs. HC men) plotted as t-maps; warm colors indicate higher values in MS; d) correlations between “cognition” and EC-value per sensor in healthy controls plotted as a r-map, warm colors indicate positive correlation; e) same as d) in MS-patients.</p

Baseline characteristics of healthy controls and MS patients.

<p>Means (±SD) are given, for EDSS, T2 and T1 medians (range); EDSS: expanded disability status scale; “cognition”: average of z-scores over seven cognitive domains; NGMV: normalized grey matter volume; NWMV: normalized white matter volume; T2: T2-hyperintense lesion volume; T1: T1-hypointense lesion volume.</p>*<p> = p<0.05 and ** = p<0.01 for comparison between healthy controls and MS patients.</p>+<p> = p<0.05 and ⁺⁺ = p<0.01 for comparison between MS women and MS men.</p

Relationship between nodal centrality and “cognition”: number of significantly correlated sensors per region, side and frequency band in MS patients.

<p>Number of sensors with significant correlations (p<0.01; in brackets: p<0.05 corrected); for definition of frequency bands refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0042087#pone-0042087-t002" target="_blank">Table 2</a>.</p

Additional file 1: Figure S1. of Microstate connectivity alterations in patients with early Alzheimer’s disease

Mapping of the 22 regions: 170 of 257 electrodes (HydroCel GSN; Electrical Geodesic Inc. [EGI]) were used to define the 22 regions. (TIF 2594 kb