An Exploratory Graphical Method for Identifying Associations in r x c Contingency Tables

On finding a significant association between rows and columns of an r x c contingency table, the next step is to study the nature of the association in more detail. The use of a scree plot to visualize the largest contributions to Χ2 among all cells in the table in order to determine the nature of the association in more detail is proposed

A computational approach for genome-wide mapping of splicing factor binding sites

A computational method is presented for genome-wide mapping of splicing factor binding sites that considers both the genomic environment and evolutionary conservation

Abundance gradients in the Milky Way for alpha elements, Iron peak elements, Barium, Lanthanum and Europium

We model the abundance gradients in the disk of the Milky Way for several chemical elements (O, Mg, Si, S, Ca, Sc, Ti, Co, V, Fe, Ni, Zn, Cu, Mn, Cr, Ba, La and Eu), and compare our results with the most recent and homogeneous observational data. We adopt a chemical evolution model able to well reproduce the main properties of the solar vicinity. We compute, for the first time, the abundance gradients for all the above mentioned elements in the galactocentric distance range 4 - 22 kpc. The comparison with the observed data on Cepheids in the galactocentric distance range 5-17 kpc gives a very good agreement for many of the studied elements. In addition, we fit very well the data for the evolution of Lanthanum in the solar vicinity for which we present results here for the first time. We explore, also for the first time, the behaviour of the abundance gradients at large galactocentric distances by comparing our results with data relative to distant open clusters and red giants and select the best chemical evolution model model on the basis of that. We find a very good fit to the observed abundance gradients, as traced by Cepheids, for most of the elements, thus confirming the validity of the inside-out scenario for the formation of the Milky Way disk as well as the adopted nucleosynthesis prescriptions.Comment: 11 pages, 9 figures, accepted for publication in A&

Selective injection of magnetic domain walls in Permalloy nanostripes

Selective injection of magnetic domain walls in Permalloy nanostripe

The nature of localization in graphene under quantum Hall conditions

Particle localization is an essential ingredient in quantum Hall physics [1,2]. In conventional high mobility two-dimensional electron systems Coulomb interactions were shown to compete with disorder and to play a central role in particle localization [3]. Here we address the nature of localization in graphene where the carrier mobility, quantifying the disorder, is two to four orders of magnitude smaller [4,5,6,7,8,9,10]. We image the electronic density of states and the localized state spectrum of a graphene flake in the quantum Hall regime with a scanning single electron transistor [11]. Our microscopic approach provides direct insight into the nature of localization. Surprisingly, despite strong disorder, our findings indicate that localization in graphene is not dominated by single particle physics, but rather by a competition between the underlying disorder potential and the repulsive Coulomb interaction responsible for screening.Comment: 18 pages, including 5 figure

Does distance matter? Variations in alternative 3′ splicing regulation

Alternative splicing constitutes a major mechanism creating protein diversity in humans. This diversity can result from the alternative skipping of entire exons or by alternative selection of the 5′ or 3′ splice sites that define the exon boundaries. In this study, we analyze the sequence and evolutionary characteristics of alternative 3′ splice sites conserved between human and mouse genomes for distances ranging from 3 to 100 nucleotides. We show that alternative splicing events can be distinguished from constitutive splicing by a combination of properties which vary depending on the distance between the splice sites. Among the unique features of alternative 3′ splice sites, we observed an unexpectedly high occurrence of events in which a polypyrimidine tract was found to overlap the upstream splice site. By applying a machine-learning approach, we show that we can successfully discriminate true alternative 3′ splice sites from constitutive 3′ splice sites. Finally, we propose that the unique features of the intron flanking alternative splice sites are indicative of a regulatory mechanism that is involved in splice site selection. We postulate that the process of splice site selection is influenced by the distance between the competitive splice sites

Magnetization reversal signatures in the magnetoresistance of magnetic multilayers

The simultaneous determination of magnetoresistance and vectorial-resolved magnetization hysteresis curves in a spin valve structure reveals distinct magnetoresistive features for different magnetic field orientations, which are directly related to the magnetization reversal processes. Measurements performed in the whole angular range demonstrate that the magnetoresistive response originates from the intrinsic anisotropic angular dependence of the magnetization orientation between the two ferromagnetic layers. This also provides direct proof that the spin-dependent scattering in the bulk of the magnetic layers is at the origin of the magnetoresistive signal

Observation of Electron-Hole Puddles in Graphene Using a Scanning Single Electron Transistor

The electronic density of states of graphene is equivalent to that of relativistic electrons. In the absence of disorder or external doping the Fermi energy lies at the Dirac point where the density of states vanishes. Although transport measurements at high carrier densities indicate rather high mobilities, many questions pertaining to disorder remain unanswered. In particular, it has been argued theoretically, that when the average carrier density is zero, the inescapable presence of disorder will lead to electron and hole puddles with equal probability. In this work, we use a scanning single electron transistor to image the carrier density landscape of graphene in the vicinity of the neutrality point. Our results clearly show the electron-hole puddles expected theoretically. In addition, our measurement technique enables to determine locally the density of states in graphene. In contrast to previously studied massive two dimensional electron systems, the kinetic contribution to the density of states accounts quantitatively for the measured signal. Our results suggests that exchange and correlation effects are either weak or have canceling contributions.Comment: 13 pages, 5 figure

C IV absorption in damped and sub-damped Lyman-alpha systems: correlations with metallicity and implications for galactic winds at z~2-3

We present a study of C IV absorption in a sample of 63 damped Lyman-alpha (DLA) systems and 11 sub-DLAs in the redshift range 1.75<z_abs<3.61, using a dataset of high-resolution (6.6 km/s FWHM), high signal-to-noise VLT/UVES spectra. Narrow and broad C IV absorption line components indicate the presence of both warm, photoionized and hot, collisionally ionized gas. We report new correlations between the metallicity (measured in the neutral-phase) and each of the C IV column density, the C IV total line width, and the maximum C IV velocity. We explore the effect on these correlations of the sub-DLAs, the proximate DLAs (defined as those within 5 000 km/s of the quasar), the saturated absorbers, and the metal line used to measure the metallicity, and we find the correlations to be robust. There is no evidence for any difference between the measured properties of DLA C IV and sub-DLA C IV. In 25 DLAs and 4 sub-DLAs, covering 2.5 dex in [Z/H], we directly observe C IV moving above the escape speed, where v_esc is derived from the total line width of the neutral gas profiles. These high-velocity C IV clouds, unbound from the central potential well, can be interpreted as highly ionized outflowing winds, which are predicted by numerical simulations of galaxy feedback. The distribution of C IV column density in DLAs and sub-DLAs is similar to the distribution in Lyman Break galaxies, where winds are directly observed, supporting the idea that supernova feedback creates the ionized gas in DLAs. The unbound C IV absorbers show a median mass flow rate of ~22(r/40 kpc) solar masses per year, where r is the characteristic C IV radius. Their kinetic energy fluxes are large enough that a star formation rate (SFR) of ~2 solar masses per year is required to power them.Comment: 21 pages, accepted to A&A, Fig 1 downgraded, v2 with proof corrections made and improved Fig 1