Senior Recital

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WAAA!

40 million unattended births, 2.8 million neonatel deaths with 1 million babies dying on the day they are born due to inadequate care and scarce human resources. The aims of WAAA! are in tune with the WHO and Unicef’s Every New Born Vision (2015 and the new sustainable development goal- 3.1: preventing avoidable newborn deaths. WAAA! (Wearable, Anytime, Anywhere, APGAR) comprises of APGAR education, a celleluar gateway and a 9 wearable. The Apgar scale is universal tool used to assess neonatal vital signs: Appearance, Pulse, Grimace, Activity & Respiratory. The system monitors newborns by proxy and when they are at most risk: the first minute, the first hour, the first day of life. Dangerous respiratory and pulse levels triggers the gateway box to send a SMS text alert to village health teams to activate an emergency response. WAAA has the capability to collect birth registration data and monitor regional neonatal trends/ initiatives for 0.32 per birth

Dynamic visits of cortical structures probe for cell size.

All cells show size homeostasis owing to coordination of division with growth. In this issue, Allard et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709171) establish that transient inhibitory visits of a negative regulator of Cdk1 to cortical oligomeric platforms increase in number and duration with cell growth, suggesting how Cdk1 activation is coupled to cell size

Senior Recital

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Morelli Quintet

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Dynamics, scaling behavior, and control of nuclear wrinkling

The cell nucleus is enveloped by a complex membrane, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling during multicellular development remain poorly understood due to a lack of direct quantitative measurements. Here, we combine live-imaging experiments, theory, and simulations to characterize the onset and dynamics of nuclear wrinkling during egg development in the fruit fly, Drosophila melanogaster, when nurse cell nuclei increase in size and display stereotypical wrinkling behavior. A spectral analysis of three-dimensional high-resolution data from several hundred nuclei reveals a robust asymptotic power-law scaling of angular fluctuations consistent with renormalization and scaling predictions from a nonlinear elastic shell model. We further demonstrate that nuclear wrinkling can be reversed through osmotic shock and suppressed by microtubule disruption, providing tunable physical and biological control parameters for probing mechanical properties of the nuclear envelope. Our findings advance the biophysical understanding of nuclear membrane fluctuations during early multicellular development.Comment: Main text: 10 pages, 3 figures. SI: 19 pages, 10 figures, 1 tabl

Junior Recital

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Senior Recital

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Junior Recital

List of performers and performances

Senior Recital

List of performers and performances