Presencia de células tubulares renales reactivas en pacientes con enfermedad renal crónica

In patients with kidney disease, the presence of reactive renal cells has been reported. These cells show several morphological alterations that difficult their classification and interpretation. Therefore, the knowledge of its morphological characteristics and sediments patterns where they can be found will helpful for their correct management by medical departments. Here, we reported the presence of renal cells grouped in acinus with abundant cytoplasm, cariomegaly, irregular nuclear contours and prominent nucleoli, accompanied with cilindruria and fatty oval bodies in the urinary sediment of two patients with Diabetes Mellitus, these cells were named as reactive renal cells.En pacientes con enfermedad renal se ha reportado la presencia de células renales reactivas, cuyas alteraciones morfológicas severas dificultan su clasificación e interpretación. El conocimiento de las características morfológicas y los patrones de sedimentos en donde se presentan pueden ser de ayuda para su manejo en los departamentos médicos correspondientes. Aquí, nosotros reportamos la presencia de células agrupadas en acinos, con abundante citoplasma, cariomegalia, contornos nucleares irregulares y nucléolos prominentes, acompañados de cilindruria y cuerpos ovales grasos en el sedimento urinario de dos pacientes con diabetes mellitus, las cuales fueron sugestivas de células renales reactivas

Identity of the commune of Hualpen and some of its main urban-populational elements

Before being created in 2003, the commune of Hualpén was foreseeing as a large neighbourhood of the commune of Talcahuano, and its name was related semantically to the area of Hualpencillo.Hualpén’s urban development, initiated in the middle of the twentieth century with the creation of Hualpencillo’s airport as one of the few of the country, can be understood as a sum of neighbourhood settlements that were randomly arranged in the urban communal territory and that are still undergoing a process of consolidation.This article reviews some of the most relevant and recognisable urban elements that form part of the current inter-communal conurbation Concepción- Talcahuano, that for its size and population represents one of the focal points of one of the main metropolitan areas of Chile.La actual comuna de Hualpén, antes de ser creada en el año 2003, se vislumbraba como un gran barrio de la comuna de Talcahuano y se relacionaba su nombre semánticamente como el sector de Hualpencillo.El desarrollo urbanístico de Hualpén, que se inicia a mediados del siglo XX con la instalación del Aeródromo de Hualpencillo como uno de los pocos del país, se puede entender como una sumatoria de asentamientos poblacionales que fueron dispuestos en forma aleatoria en el territorio urbano comunal y que aún se encuentra en proceso de consolidación.En este trabajo, se reconocen algunos de los principales y más reconocibles elementos urbanos que conforman parte de la actual conurbación de la intercomuna Concepción-Talcahuano y que por su extensión y población la convierten en un área neurálgica de una de los principales áreas metropolitanas de Chile

Modeling of E. coli distribution for hazard assessment of bathing waters affected by combined sewer overflows

Combined sewer overflows (CSOs) affect bathing water quality of receiving water bodies by bacterial pollution. The aim of this study is to assess the health hazard of bathing waters affected by CSOs. This is useful for bathing water managers, for risk assessment purposes, and for further impact and economic assessments. Pollutant hazard was evaluated based on two novel indicators proposed in this study: the mean duration of insufficient bathing water quality (1) over a period of time (i.e., several years) and (2) after single CSO/rain events. In particular, a novel correlation between the duration of seawater pollution and the event rainfall volume was developed. Pollutant hazard was assessed through a coupled urban drainage and seawater quality model that was developed, calibrated and validated based on local observations. Furthermore, hazard assessment was based on a novel statistical analysis of continuous simulations over a 9-year period using the coupled model. Finally, a validation of the estimated hazard is also shown. The health hazard was evaluated for the case study of Badalona (Spain) even though the methodology presented can be considered generally applicable to other urban areas and related receiving bathing water bodies. The case study presented is part of the EU-funded H2020 project BINGO (Bringing INnovation to OnGOing water management - a better future under climate change)

An Optimization Approach to Eliminate Crosstalk in Zero-Potential Circuits for Reading Resistive Sensor Arrays

Crosstalk is a well-known problem in resistive sensor arrays (RSAs). The zero-potential method (ZPM) is a commonly used readout circuit that uses multiplexers and demultiplexers to reduce the main sources of crosstalk. However, the internal resistors of these switches cause a secondary crosstalk in the RSA that alters the RSA sensor values read. The solution to the effects of this secondary crosstalk is still a case of study. In previous literature, these resistances have been considered as known and, in most cases, equal for all switch channels. However, in a real situation, they are unknown and may vary between channels. In this work, a least-squares (LSQR) method is presented to obtain the true values of the switches from the read voltage signals. Calibration columns are added to the RSA for this purpose. To prove the performance of the method proposed, several simulations have been carried out with different values of RSA sensors, switch resistances, size of the RSA, and noise level. Results show that the proposed LSQR method allows obtaining simultaneously accurate values for both the RSA sensors and switch internal resistors. In this way, the problem of secondary crosstalk is neutralized. It also shows better performance when compared with existing approaches

The Efficacy and Patient Satisfaction with a Mini-Scleral Lens after penetrating Keratoplasty

Background: To analyse the efficacy and patient satisfaction of fitting a mini-scleral lens (SL) after keratoplasty surgery in patients unsatisfied with their visual outcomes. Material and Methods: A retrospective chart review of 22 consecutive patients was performed between 2018 and 2019. Demographic data, indications for keratoplasty, ocular parameters, and visual results were evaluated. In addition, subjective visual quality (SVQ) and comfort, complications, daily wear time, and the reason for discontinuing SL wear during the 6-month follow-up were analysed. Results: Twenty-two eyes of 22 patients (6 females and 16 males; mean age 48.82 ± 17.19 years) were assessed. Keratoconus was the main indication for keratoplasty (9 eyes, 40.9%), followed by corneal opacities (5 eyes), and Fuchs endothelial dystrophy (4 eyes). High refractive anisometropia was found in 14 eyes (63.6%) and 6 eyes presented significant irregular astigmatism. LogMAR visual acuity improved significantly with SL when compared with the best spectacle-correction (mean, 0.12 ± 0.12 vs 0.52 ± 0.33, respectively; p < 0.01). Six patients discontinued SL wear (27.3%). Among the other 16 patients, the mean daily wear time was 11.47 ± 1.52 h; of these, 14 (87.5%) were successfully fitted and enjoyed favourable SVQ and comfort. No significant complications were found during the follow-up period. Conclusions: Mini-scleral lenses may be a safe and effective alternative for treating complicated eyes after keratoplasty; they may provide optimal visual rehabilitation and/or restore binocular vision with significant efficacy and patient satisfaction

Magnetic Anomalies in Extensional Detachments: The Xistral Tectonic Window of the Lugo Dome (NW Spain)

[EN]Magnetic anomalies in the Lugo gneiss dome of the NW Iberian Massif are related with outcropping late Variscan extensional detachments The sources of magnetic anomalies are high‐grade metamorphic rocks, including migmatites and inhomogeneous granites The Lugo Dome is one of a series that coincides with a broad, curved magnetic anomaly that delineates an orocline in NW Iberi

Characterization of the Eastern Galicia Magnetic Anomaly. A warning regarding the interpretation of aeromagnetic data

[EN]Caution should be applied to the interpretation of aeromagnetic data since often they use unknown geological bodies of unknown characteristics to explain the anomalies. A case study in the Lugo Sanabria Extensional Dome (NW Spain) shows that what was interpreted as an anomaly sourced by a basic/ultrabasic magnetic body from the lower crust/mantle, seems to be related to magnetization along extensional detachments in relation to the orogenic evolution of a thickenend Variscan crust

¿Qué enseñar en la educación obligatoria acerca de la alimentación y actividad física? Un estudio con expertos

Durante la etapa de educación secundaria, los jóvenes suelen reducir su actividad física y modificar sus hábitos alimentarios de manera negativa. Los objetivos de este trabajo son identificar los problemas de salud más relevantes para la educación en el campo de la alimentación y la actividad física, así como las competencias necesarias para resolverlos. Para ello, se realizó una revisión bibliográfica y una consulta a expertos a través de un estudio Delphi y de un encuentro presencial. Esta combinación ha permitido consensuar entre diferentes sectores profesionales no solamente una lista de problemas y contenidos competenciales necesarios, sino también aquellos considerados como prescindibles. Los resultados de este estudio permitirán actualizar la educación alimentaria en la escuela y replantearse el currículum de ciencias desde una perspectiva que integre su enseñanza con la educación físic

Magnetic anomalies associated to extensional detachments? An example at Xistral TectonicWindow of the Lugo Dome (NW Spain)

[EN]Magnetic anomalies in the Lugo gneiss dome of the NW Iberian Massif are related with outcropping late Variscan extensional detachments The sources of magnetic anomalies are high‐grade metamorphic rocks, including migmatites and inhomogeneous granites The Lugo Dome is one of a series that coincides with a broad, curved magnetic anomaly that delineates an orocline in NW Iberi

Preclinical evaluation of the antimicrobial-immunomodulatory dual action of xenohormetic molecules against haemophilus influenzae respiratory infection

Chronic obstructive pulmonary disease (COPD) is characterized by abnormal inflammation and impaired airway immunity, providing an opportunistic platform for nontypeable Haemophilus influenzae (NTHi) infection. In this context, therapies targeting not only overactive inflammation without significant adverse effects, but also infection are of interest. Increasing evidence suggests that polyphenols, plant secondary metabolites with anti-inflammatory and antimicrobial properties, may be protective. Here, a Cistus salviifolius plant extract containing quercetin, myricetin, and punicalagin was shown to reduce NTHi viability. Analysis of these polyphenols revealed that quercetin has a bactericidal effect on NTHi, does not display synergies, and that bacteria do not seem to develop resistance. Moreover, quercetin lowered NTHi airway epithelial invasion through a mechanism likely involving inhibition of Akt phosphorylation, and reduced the expression of bacterially-induced proinflammatory markers il-8, cxcl-1, il-6, pde4b, and tnfα. We further tested quercetin’s effect on NTHi murine pulmonary infection, showing a moderate reduction in bacterial counts and significantly reduced expression of proinflammatory genes, compared to untreated mice. Quercetin administration during NTHi infection on a zebrafish septicemia infection model system showed a bacterial clearing effect without signs of host toxicity. In conclusion, this study highlights the therapeutic potential of the xenohormetic molecule quercetin against NTHi infection