El sistema pronominal en el orador Esquines

The present Paper analyzes the pronominal System in Aeschines. This is especially importât becouse here we can find many uses that later, in the koiné, become widerspread. For instance we find the reduction from three to two forms of demonstrative pronoums, the increase of uses of reflexive pronouns, the confusion of the value between relaties and indefinite pronoums and the appearance of recentforms taken from old adjetivs as ïdios and oiKeîos

Algunas notas sobre el sufijo castellano -oso y sus derivados

En este trabajo nos proponemos mostrar algunas de las características del sufijo español -oso y de los derivados que lo portan desde los puntos de vista sincrónico y diacrónico. El afijo se presenta como de amplio espectro en lo relativo a productividad, entendida esta tanto en términos cuantitativos como cualitativos (términos referidos al número de derivados que el sufijo puede crear y a la regularidad con la que se producen los eductos derivados). Buena prueba de su productividad es el número de palabras que presentan este su-fijo en la lengua castellana ―supera ligeramente el millar― y su polivalencia en cuanto al tipo de derivación que procesa

Water governance challenges at a local level: implementation of the OECD Water Governance Indicator Framework in the General Pueyrredon Municipality, Buenos Aires Province, Argentina

Considering that the current water crisis is largely a governance crisis, improving water governance will help to address current and future water challenges. Water governance is defined as the range of political, institutional and administrative rules, practices and processes through which decisions are taken and implemented, stakeholders can articulate their interests and have their concerns considered, and decision makers are held accountable for water management. The Water Governance Principles proposed by the Organisation for Economic Co-operation and Development (OECD) contribute to the creation of tangible public policies oriented toward effectiveness, efficiency, reliability and participation. The aim of this research is to apply the OECD Water Governance Indicator Framework at a local level and to identify gaps and challenges for water governance in the General Pueyrredon Municipality (GPM), Buenos Aires Province (BAP), Argentina. This framework was used as a diagnostic tool to assess water governance policy frameworks (what), institutions (who) and instruments (how). In general terms, there is a robust legal framework, there are enforcement institutions regarding water management and there is a good connection with them. However, the main challenges identified were in the ‘how’, since most of the instruments are partly or not implemented.Fil: Martín Velasco, María José. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto de Geología de Costas y del Cuaternario; ArgentinaFil: Calderon, Gabriela. Ministerio de Ciencia. Tecnología e Innovación Productiva. Agencia Nacional de Promoción Científica y Tecnológica; Argentina. Universidad Nacional de Mar del Plata. Facultad de Arquitectura, Urbanismo y Diseño; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Lima, María Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad Nacional de Mar del Plata. Facultad de Arquitectura, Urbanismo y Diseño. Instituto de Hábitat y Medio Ambiente; ArgentinaFil: Mantecón, Cecilia Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Massone, Hector Enrique. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Geología de Costas y del Cuaternario. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto de Geología de Costas y del Cuaternario; Argentin

Material selection for spallation neutron source windows. Application to PDS-XADS and XT-ADS prototypes

High performance neutron sources are being proposed for many scientific and industrial applications, ranging from material studies, hybrid reactors and transmutation of nuclear wastes. In the case of transmutation of nuclear wastes, accelerator driven systems (ADS) are considered as one of the main technical options for such purpose. In ADS a high performance spallation neutron source becomes an essential element for its operation and control. This spallation source must fulfil very challenging nuclear and thermo-mechanical requirements, because of the high neutron rates needed in ADS. The material selection for this key component becomes of paramount importance, particularly the source window that separates the vacuum accelerator tube from the spallation material where the accelerated protons impinge. In this paper, an integral analysis of spallation sources is done, taking as a reference the projects in this field proposal in the framework of European projects. Our analysis and calculations show that titanium and vanadium alloys are more suitable than steel as structural material for an industrial ADS beam window, mostly due to its irradiation damage resistance

Cytotoxic effects of curcumin in osteosarcoma cells

Carta al editor de International Journal of Nanomedicine, en la que los autores puntualizan ciertos resultados de investigaciones de R. Chang et al.; y de D. K. Walters et al. en relación a sus aplicaciones para la curación de algunos cánceres y enfermedades óseas metabólicas.Letter to the editor of International Journal of Nanomedicine, in which the authors point out certain results of research by R. Chang et al.; and DK Walters et al. in relation to their applications for the cure of some cancers and metabolic bone diseases

Giant Isolated Omphalocele: Role of Prenatal Diagnosis in Prognostic Asessment and Perinatal Management

Article ID 4578912[EN]Omphalocele is a congenital malformation of the abdominal wall consisting of a protrusion of the abdominal contents at the base of the umbilical cord. It has a high association with genetic and structural defects; however, if the latter is ruled out, its prognosis improves significantly. Prenatal diagnosis has a key role in this condition as omphalocele can be diagnosed by ultrasound in the first trimester scan, enabling a coordinated approach strategy to achieve the best perinatal results. We present a case report of a pregnant patient with a fetus having a giant omphalocele in which prenatal diagnosis played a decisive role, allowing the coordination of a multidisciplinary team, which was crucial in the immediate care of the newborn

Una aproximación al estudio de la eficiencia en las agencias de viajes

El objetivo del artículo se basa en evaluar la eficiencia de las de las Agencias de Viajes españolas en su actividad de gestión. Con tal fin se realiza un análisis que considera conjuntamente indicadores de recursos e indicadores de resultado de las agencias utilizadas en el estudio. La metodología aplicada se apoya en la técnica no paramétrica de medición de la eficiencia conocida como Análisis Envolvente de Datos (DEA). Esta técnica permite estimar la eficiencia técnica y de escala con la que operan las agencias de viajes. El artículo explica además la eficiencia de dicho sector mediante aquellas variables relacionadas con la estrategia de integración de cada unidad de análisis utilizando un modelo de regresión tobit. La aplicación empírica realizada sobre una muestra de 40 agencias de viajes evidencia elevados índices de ineficiencia técnica y escala, así como el importante impacto que la integración vertical/horizontal tiene sobre el nivel de eficiencia de las mismas.The aim of the article is based on the evaluation of the efficiency in the management activities of the Spanish Travel Agencies. According to this objective, an analysis based on input and output indicators of each Travel Agencies are used. The methodology applied, held by a non-parametric technique for the measurement of efficiency, is known as Data Envelopment Analysis (DEA). This technique allows us to estimate the technological and scale efficiency of those Travel Agencies involved in the study. The article explains the efficiency of that sector as a function of those variables related to the integration strategic of each unit of analysis using the Tobit Regression Model. The empirical application over a sample of 40 agencies gives evidence of both the high technological and scale inefficiencies and the important impact of the horizontal/vertical integration on the level of efficiency of those agencies considered in the study

Reliability of measurements during countermovement jump assessments: Analysis of performance across subphases

The aim of this study was to examine the reliability of performance measures in the different phases and sub-phases of the countermovement jump (CMJ). Seventeen male athletes competing at a regional level completed 204 valid trails consisting of the execution of maximal hands-on-waist CMJs performed on a force platform. The vertical ground reaction force (VGRF) data obtained at a sampling frequency of 1000 Hz were used to calculate performance-derived variables and determine key points and jump subphases. The relative reliability of 92 variables was assessed using the intraclass correlation coefficient (ICC) from a two-way mixed effects model analyzing the time, force, power, velocity, and displacement variables across the different phases and sub-phases of the jump. The contact phase serves as a consistent approach (range ICC = .806 to .987), providing reliable information about the jump as a unit. Mean force was the only measure that presented high reliable values throughout all sub-phases (ICC = .931 to .963). The power and velocity variables were reliable from the point where force turned into an increasing value while displacement from minimum velocity was reached. Net impulse and ratios of force development showed high and acceptable values, respectively. Timerelated variables were the least reliable measures (ICC = .587 to .720), showing acceptable reliability only in the contact phase and propulsive sub-phase. In conclusion, VGRF may be used to determine specific parameters during CMJ execution, although the appropriate variables should be selected based on acceptable levels of reliability.S

Beneficial effects of paricalcitol on cardiac dysfunction and remodelling in a model of established heart failure

The synthetic vitamin D3 analogue paricalcitol acts as a selective activator of the vitamin D receptor (VDR). While there is evidence for cardioprotective effects of paricalcitol associated with the VDR pathway, less information is available about the structural and functional cardiac effects of paricalcitol on established heart failure (HF) and particularly its effects on associated electrophysiological or Ca2+ handling remodelling. EXPERIMENTAL APPROACH: We used a murine model of transverse aortic constriction (TAC) to study the effect of paricalcitol on established HF. Treatment was initiated 4 weeks after surgery over five consecutive weeks, and mice were sacrificed 9 weeks after surgery. Cardiac MRI (CMRI) was performed 4 and 9 weeks after surgery. Hearts were used for biochemical and histological studies and to isolate ventricular myocytes for electrophysiological and calcium imaging studies. KEY RESULTS: CMRI analysis revealed that, compared with vehicle, paricalcitol treatment prevented the progression of ventricular dilation and hypertrophy after TAC and halted the corresponding decline in ejection fraction. These beneficial effects were related to the attenuation of intracellular Ca2+ mishandling remodelling, antifibrotic and antihypertrophic effects and potentially antiarrhythmic effects by preventing the reduction of K+ current density and the long QT, JT and TpTe intervals observed in HF animals. CONCLUSION AND IMPLICATIONS: The results suggest that paricalcitol treatment in established HF hampers disease progression and improves adverse electrophysiological and Ca2+ handling remodelling, attenuating the vulnerability to HF-associated ventricular arrhythmias. Paricalcitol may emerge as a potential therapeutic option in the treatment of HFThis work was supported by the Spanish Ministry of Economy and Competitiveness (SAF2014- 57190R, SAF2017-84777-R), ISCIII (PI17/01093 and PI17/01344), European Regional Development Fund (FEDER), Sociedad Española de Cardiología (SEC), and CIBER-CV, a network funded by ISCIII. MF-V is a Miguel Servet II researcher of ISCIII (MSII16/00047 Carlos III Health Institute). GR-H is a Miguel Servet I researcher of ISCIII (CP15/00129 Carlos III Health Institute). MT is a predoctoral fellow of the Spanish Ministry of Science, Innovation and Universities (FPU-17/06135