The development of proliferative verrucous leukoplakia in oral lichen planus: a preliminary study

Background: Was to describe 14 cases of a proliferative verrucous leukoplakia as a clinical evolution of oral lichen planus. Material and Methods: The clinical and histopathological characteristics of 14 cases of OLP that progress towards a plaque-like and verrucous form were indicated, with monitoring over a period of six to 24.3 years. Results: The female/male ratio was 11/3, (78.6 and 21.4%). The mean age when the first biopsy was undertaken was 56.4 years old. None of the patients smoked during the study. As bilateral reticular was clinically diagnostic criterion, the second most frequent clinical form was the plaque form (n=10; 71.4%), followed by the atrophic (n=6; 42.8%), and erosive forms (n=4; 28.5%). Clinically it spread towards attached gingival mucosa and the hard palate. In the histopathologic study, there were a predominance of hyperkeratosis and verrucous epithelial hyperplasia. Three of the cases progressed to a squamous cell carcinoma, and one patient developed two verrucous carcinoma. Conclusions: Further research is needed to demonstrate if proliferative multifocal oral lichen planus and proliferative multifocal oral leukoplakia are the same disorder but have different behaviour of malignancy for reasons of origin

Evaluación regional de inestabilidades de ladera por efecto sísmico: Mapas de desplazamiento de Newmark para la Cuenca de Lorca (SE España)

El sureste de España está caracterizado por una sismicidad de baja a moderada magnitud. Sin embargo, los terremotos de baja magnitud (Mw=4.0-4.5) pueden producir daños significativos en las edificaciones, así como inestabilidades de ladera (caída de rocas, principalmente). En este trabajo se presenta un mapa de desplazamientos de Newmark para la Cuenca de Lorca considerando diferentes escenarios sísmicos. Para su construcción se ha elaborado un mapa litológico basado en los mapas geológicos del IGME, asignando a cada unidad valores de peso específico, cohesión y ángulo de fricción obtenidos de bibliografía y de ensayos geotécnicos. Estos mapas se combinan con el mapa de pendientes generado a partir de un modelo digital de elevaciones (MDE) para obtener un mapa de factores de seguridad estáticos. Combinando éste con el de pendientes se obtiene el mapa de aceleraciones críticas (ac) que representa la susceptibilidad sísmica al deslizamiento. Se han considerado varios escenarios sísmicos para los que se ha aplicado factores de amplificación del terreno y topográfico para obtener los mapas de aceleración sísmica máxima (PGA). Los desplazamientos de Newmark (DN) se obtienen empleando una ecuación empírica en función del ratio K (ac/PGA). Los mapas obtenidos permiten identificar las áreas de potencial riesgo en la Cuenca de Lorca. En general, las inestabilidades esperables serán de tipo desprendimiento, particularmente caídas de rocas

Estudio preliminar de la estabilidad en condiciones dinámicas del deslizamiento de Bàlitx (Sierra de Tramuntana, Mallorca)

En este trabajo se realiza un estudio preliminar de estabilidad retrospectivo en condiciones dinámicas del deslizamiento de Bàlitx (Mallorca). Este gran movimiento de ladera se localiza en la franja costera del sector central de la Sierra de Tramuntana, en la parte noroccidental de la isla de Mallorca. El área se caracteriza por el predominio de materiales rocosos carbonatados (calizas y dolomías) del Jurásico inferior (Lías) que configuran espectaculares acantilados rocosos de varios centenares de metros de altura. En el caso del deslizamiento de Bàlitx, estos materiales carbonatados se disponen sobre los materiales blandos del Triásico (facies Keuper), constituidos principalmente por margas y arcillas con yesos. Teniendo en cuenta que en la isla de Mallorca existen registros de sismicidad histórica y que, además, presenta una peligrosidad sísmica moderada, el estudio en condiciones dinámicas del deslizamiento de Bàlitx ha permitido confirmar su posible origen sísmico. Se ha estimado que el deslizamiento pudo ser provocado por un terremoto de magnitud moderada a alta (Mw=4.7-6.5) localizado en las inmediaciones del deslizamiento (≤ 20 km). [ABSTRACT]In this work we perform a slope stability back-analysis of the Bàlitx landslide in dynamic conditions. This slope instability is located on the coast of the central sector of the Tramuntana Range, in Majorca Island. This area is characterized by the predominance of Jurassic limestones, on which spectacular cliffs of several hundred metres have been developed. In the Bàlitx landslide, these carbonated materials lie on top of Triassic soft materials (Keuper facies), composed mainly of marls and clays with gypsum. In this work we focus on analyzing the possibility that the Bàlitx landslide was triggered by an earthquake. Majorca Island, although it is considered as a region of low-to-moderate seismic hazard, shows historical damaging earthquakes and Quaternary active faults. We have concluded preliminary that the Bàlitx landslide could have been triggered by a moderate-to-large earthquake (Mw=4.7-6.5) located relatively close to the landslide (≤ 20 km)

Oral hygiene instructions and professional control as part of the treatment of desquamative gingivitis. Systematic review

The aim of this present article was to evaluate the scientific evidence on the efficacy of daily hygiene and professional prophylaxis for treatment of desquamative gingivitis. The present systematic review was conducted following the PRISMA protocol. Searches were carried out in Pubmed, Embase, Web of Science and Cochrane Library up to July 2018, randomized clinical trials and cohort studies on desquamative gingivitis (DG), and oral diseases joined to DG. After screening, we found that nine publications met the eligibility criteria eight cohort studies and one randomized control trial. The diagnosis of the diseases corresponded to oral lichen planus (n=185), mucous membrane pemphigoid (n=13); plasma cell gingivitits (n=15) and pemphigus vulgar (n=11). The follow-up was between a week and a year after instructing patients. Dental daily hygiene and professional prophylaxis, at least with supragingival scaling and polishing have significantly improved the extension of the lesion and reduced the activity of DG, and gingival bleeding in all patients. Furthermore, these techniques have also reduced pain and gingival plaque. In conclusion the studies presented support the efficacy of maintaining personal and professional oral hygiene in patients with GD, reducing the clinical signs of the disease, regardless of its pathogenesis

Tectónica activa de la Cuenca de Málaga: evidencias en marcadores morfotectónicos (Cordillera Bética Occidental, España)

The Malaga Basin is located in the westernmost part of the Betic Cordillera. This alpine cordillera in the south of Spain is the most active region of the Iberian Peninsula. Some of the most destructive earthquakes occurred historically in Spain took place within the Malaga Basin. In this work we focus on geomorphic and morphotectonic observations in the aim of finding active tectonic structures that could be seismogenic sources. First, we study the spatial arrangement and age of the Quaternary alluvial fan system as well as the drainage pattern of the basin, followed by the analysis of the distribution of regional markers like marine erosive surfaces and the extend of Pliocene marine deposits in the Malaga Basin. The tectonic structures inferred as active by the morphotectonic analysis are grouped into four main families: N60º-85ºE folds associated with blind thrust faults, N20º-30ºE and N40º-50ºE high angle dip-slip faults, and N165º-170ºE tear faults. Finally, their seismic potential in terms of maximum moment magnitude (Mw) is assessed by means of empirical relationships, varying between 6.0 and 7.0 depending on the hypothesis considered.La cuenca de Málaga se sitúa en la parte más occidental de la cordillera Bética. En esta cordillera alpina del sur de España se han localizado algunos de los terremotos más destructivos ocurridos históricamente en la península Ibérica. En este trabajo se estudian algunos de los aspectos geomorfológicos de la cuenca del Málaga con el fin de identificar las estructuras tectónicas activas que pudiesen ser fuentes sismogénicas. Se estudia la distribución y edad del sistema de abanicos aluviales de la cuenca, así como la red de drenaje. También se analiza la distribución regional de marcadores tectónicos pliocenos, como superficies de erosión marina y los depósitos sedimentarios de este periodo transgresivo. Se han identificado varias estructuras tectónicas activas que han sido agrupadas en cuatro familias: pliegues N60º-85ºE asociados con falla inversas ciegas, fallas de alto buzamiento con salto en la vertical N20º-30ºE y N40º-50ºE, y fallas de transferencia N165º-170ºE. En base a relaciones empíricas se ha estimado un potencial sísmico para las fallas identificadas, obteniéndose valores de magnitud momento (Mw) entre 6,0 y 7,0

Pseudoepitheliomatous hyperplasia after diode laser oral surgery: an experimen tal study

Background : To examine the process of epithelial reparation in a surgical wound caused by diode laser. Material and Methods : A n experimental study with 27 Sprage-Dawley rats was undertaken. The animals were randomly allocated to two experimental groups, whose individuals underwent glossectomy by means of a diode laser at different wattages, and a control group treated using a number 15 scalpel blade. The animals were slaughtered at the 2nd, 7th, and 14th day after glossectomy. The specimens were independently studied by two pathologists (blinded for the specimens’ group). Results: At the 7th day, re-epithelisation was slightly faster for the control group (conventional scalpel) ( p =0.011). At the 14th day, complete re-epithelization was observed for all groups. The experimental groups displayed a pseudoepitheliomatous hyperplasia. Conclusions: It is concluded that, considering the limitations of this kind of experimental studies, early re-epithelisation occurs slightly faster when a conventional scalpel is used for incision, although re-epithelisation is completed in two weeks no matter the instrument used. In addition, pseudoepitheliomatous hyperplasia is a potential event after oral mucosa surgery with diode laser. Knowledge about this phenomenon (not previously described) may prevent diagnostic mistakes and inadequate treatment approaches, particularly when dealing with potentially malignant oral lesions

Study of association between Pre-Senile cataracts and the polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish population

To determine if the presence of certain polymorphisms in the DNA repair gene XPC and the apoptosis inductor gene p53 is associated with pre-senile cataract development. Methods We have performed a retrospective study over three groups of patients. The group with presenile cataract formed by 72 patients younger than 55 with cataract surgery. The group with senile cataract formed by 101 patients older than 55 with cataract surgery. The group without cataract was formed by 42 subjects older than 55 without lens opacities. We analyzed the presence of SNP rs2228000 from XPC and rs1042522 from p53; and the relationship between risk factors such as smoking, alcohol intake, hypertension or diabetes. Results The comparison of the genotype distribution in XPC, within the different groups, did not show any statistically significant association in any of our analysis (p>0, 05). The comparison of the genotype distribution in p53 within the different groups did not show any statistically significant association (p>0, 05); except for the comparison between the pre-senile cataract group and the group with senile cataract where the genotype Pro/Pro (C/C) in the recessive inheritance model showed a higher risk for developing pre-senile cataract (p = 0, 031; OR = 1.04-15.97). This association decreased when we performed the analysis adjusting by the studied risk factors (p = 0.056). Conclusions Allelic variants in the gene XPC are not associated with an increased risk for developing pre-senile cataract. The presence of the genotype Pro/Pro in p53 might be associated with a major risk for developing pre-senile cataract

Population structure of Asconema setubalense Kent, 1870 at Concepción Seamount, Canary Islands (Spain). Methodological approach using non-invasive techniques

The hexactinellid sponge Asconema setubalense Kent, 1870is a large bathyal species of the North Atlantic Ocean with a funnel-like body and very large osculum. Populations of A. setubalense have a three-dimensional structure and increase the complexity and biodiversity in their habitat, and are therefore considered to be a habitat-forming species. Nevertheless, at present the information on the extension, biomass, density, population structure, and ecology of this species is scarce, and it could be susceptible to the longline fishing practices that take place in the Canary Islands. The main objectives of this study are to define a functional and accurate methodology to measure specimens of A. setubalense by comparing differences in users, techniques, and morphometric measurements; to describe the height-size relationship; to present the population size structure of the species, and to establish a relationship between the size of A. setubalense and the environmental variables that can be found at the “Banco de La Concepción” seamount (BC). The obtained results suggest that surface area is the most reliable measurement to define the size of this species, whilst also showing a clear correlation with the height of the species. The selected methodology has made it possible to measure the surface area of 1035 specimens and thus obtain the size structure of the population of A. setubalense in BC. The GAM model that was used to analyse the relationship between the size of A. setubalense and the geomorphologic variables of BC, shows areas where there is a high probability of finding large specimens of the species. The results of this study greatly enhance the knowledge of this species and its habitat, and should be considered in future conservation directives, or in the development of indicators to show the good environmental state of habitats. Additionally, the study improves analysis methodology that, with the appropriate morphometric measurements, can favour the development of future studies of this species, and indeed others with a similar morphology or growth pattern.En prensa2,42

Análisis multivariante de los horizontes orgánico-minerales de los suelos del Parque Natural de Sierra Mágina (Jaén)

Soils are described normally using a great number of properties (variables). This generates a great quantity of data not easily understandable in a direct way. Consequently, multivariate analysis is necessary to support and confirm impressions and interpretations of investigations in field and laboratory. In the present work we quantify, through multivariate analysis, the relative influence of the different factors of soil formation that act on the soil system. We have studied 203 organo-mineral horizons, sampled to a depth between 0 and 25 cm of soils in the Sierra Mágina natural park (Jaén, Spain). The studied soils are from calcareous rocks. Five factors were found to be significant and showed that the organic carbon accumulation, decarbonatation and the argillization/rubefacction, as internal variables, and the hill slope, as external variable, they are those which explain a greater percentage of the natural variability of the soil system