Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer’s disease.

The search for novel therapies for the treatment of Alzheimer’s disease is an urgent need, due to the current paucity of available pharmacological tools and the recent failures obtained in clinical trials. Among other strategies, the modulation of amyloid-triggered neuroinflammation by the endocannabinoid system seems of relevance. Previous data indicate that the enhancement of the endocannabinoid tone through the inhibition of the enzymes responsible for the degradation of their main endogenous ligands may render beneficial effects. Based on previously reported data, in which we described a paradoxical effect of the genetic deletion of the fatty acid amide hydrolase, we here aimed to expand our knowledge on the role of the endocannabinoid system in the context of Alzheimer’s disease. To that end, we inhibited the production of interleukin-1, one of the main inflammatory cytokines involved in the neuroinflammation triggered by amyloid peptides, in a transgenic mouse model of this disease by using minocycline, a drug known to impair the synthesis of this cytokine. Our data suggest that interleukin-1 may be instrumental in order to achieve the beneficial effects derived of fatty acid amide hydrolase genetic inactivation. This could be appreciated at the molecular (cytokine expression, amyloid production, plaque deposition) as well as behavioral levels (memory impairment). We here describe a previously unknown link between the endocannabinoid system and interleukin-1 in the context of Alzheimer’s disease that open new possibilities for the development of novel therapeutics.pre-print646 K

Information and Communication Technologies (ICT) for training in sheep handling and production

El desarrollo de TIC para el aprendizaje de los alumnos es de suma importancia en la situación actual. Se pretende el desarrollo de material audiovisual para que la adquisición de las competencias en materia de manejo, cría y producción ovina.Depto. de Producción AnimalFac. de VeterinariaFALSEsubmitte

CUIDADO DE UN NÚCLEO DE GALLINAS EN PELIGRO DE EXTINCIÓN POR LOS ESTUDIANTES DEL DIPLOMA FORMATIVO UNIVERSITARIO LICEO-ESPECIALIDAD DE CUIDADO DE ANIMALES (GALLICEO)

Depto. de Producción AnimalDepto. de Farmacología y ToxicologíaDepto. de Investigación y Psicología en EducaciónFac. de EducaciónTRUEinpres

Pinterest: Use of social networks for horse and dog coat study

Depto. de Producción AnimalFac. de VeterinariaFALSEsubmitte

From farm to commercialization: An integration strategy in Food Science and Technology

De la Granja a la Comercialización: Una experiencia de integración. Comunicación presentada en el III Congreso CyTA-Junior. Zaragoza. 20 de junio de 2022Integración de la Granja Docente de Veterinaria en las actividades prácticas del Grado en Ciencia y Tecnología de los Alimentos; creación de una plataforma virtual como herramienta de coordinación de la producción-elaboración y comercialización de productos.Integration of the Veterinary Teaching Farm in the practical activities of the degree in Food Science and Technology; creating a virtual platform as a tool to coordinate the production, manufacture and marketing of food products.Fac. de VeterinariaFALSEsubmitte

Integrate and learn. Building a farm-to-table blockchain

DecanatoFac. de VeterinariaFALSEsubmitte