Canine Antisemitism in the Coplas del perro de Alba

El objetivo principal de este trabajo es abordar el estudio de las Coplas del perro de Alba, un texto olvidado hasta el momento por la mayor parte de la crítica, en relación con su cariz marcadamente antisemitista, el cual permite relacionarlo con numerosos textos posteriores de nuestra literatura. El alejamiento de los topoi comunes en este tipo de sátiras, la incorporación de la figura del can como principal enemigo de los judíos y la dignificación casi heroica del mismo, hacen de este texto, a pesar de su escaso mérito estético-literario, un testimonio de primera fila de las problemáticas interacciones sociales de la España del momento y, tal vez, también de la época modernaThe main objective of this essay is to bring to light and examine the Coplas del perro de Alba, a text that until now has been overlooked by critics, whereas its anti-Semitism allows us to relate it to subsequent texts. Moreover, the poem’s distancing from conventional satirical topoi, its incorporation of the dog as a principal enemy of the Jews, and its corresponding elevation of that animal to an almost heroic level permit its interpretation as an emblem of the problematic social interactions in Spain during that time, and even in the modern era

Sodomitas, putos, doncellos y maricotes en algunos textos de Quevedo

Este ensayo analiza el sistema simbólico del tratamiento de la homosexualidad por Quevedo dentro de los parámetros de la sátira y el teatro breve. Se contextualiza su significado dentro del momento histórico, cuando aquélla se consideraba una abominación y el más grave de todos los crímenes contra natura. El ingenioso y polivalente lenguaje de la sá- tira antisodomítica quevedesca revela su proximidad al verso escatoló- gico, con su fijación en el ano como locus convencional de las prácticas homosexuales. En El entremés famoso «El marión» se templa el tono y lenguaje explícito anterior, y los sodomitas y putos depravados de la sátira poética ceden ante un afeminado andrógino y sorprendentemente asexuado, revelando cómo el género literario y aspectos de la actuación teatral determinan la representación de la otredad sexual

Health-related quality of life and pain with selinexor in patients with advanced dedifferentiated liposarcoma

[Objective] Compare health-related quality of life (HRQoL) of selinexor versus placebo in patients with dedifferentiated liposarcoma.[Materials & methods] HRQoL was assessed at baseline and day 1 of each cycle using the European Organization for Research and Treatment of Cancer 30-item core quality of life questionnaire. Results were reported from baseline to day 169 (where exposure to treatment was maximized while maintaining adequate sample size).[Results] Pain scores worsened for placebo versus selinexor across all postbaseline visits, although differences in HRQoL at some visits were not significant. Other domains did not exhibit significant differences between arms; however, scores in both arms deteriorated over time.[Conclusion] Patients treated with selinexor reported lower rates and slower worsening of pain compared with patients who received placebo.This study was funded by Karyopharm Therapeutics, Inc. M Gounder: reports an institutional research grant from Karyopharm, personal fees from Karyopharm, Epizyme, Springworks, Daiichi, Bayer, Amgen, Tracon, Flatiron, Medscape, Physicians Education Resource, Guidepoint, GLG and UpToDate; and grants from the National Cancer Institute, National Institutes of Health (P30CA008748) – core grant (CCSG shared resources and core facility). ARA Razak: consulting/Ad board: Merck & Adaptimmune Research support: Karyopharm Therapeutics, Deciphera, Blueprint Medicines, Pfizer, Adaptimmune, Merck, Roche/Genentech, Bristol-Myers Squibb, Medimmune, Amgen, GSK, AbbVie, Iterion Therapeutics. AM Gilligan: employee of Karyopharm Therapeutics, Inc. H Leong: employee of Karyopharm Therapeutics, Inc. X Ma: employee of Karyopharm Therapeutics, Inc. N Somaiah: consultant for Deciphera, Blueprint, Bayer Research Support from Ascentage, Astra-Zeneca, Daiichi-Sankyo, Deciphera, Eli Lilly, Karyopharm and GSK. SP Chawla: consultant for Amgen, Roche, GlaxoSmithKline, Threshold Pharmaceuticals, CytRx Corporation, Ignyta, Immune Design, TRACON Pharma, Karyopharm Therapeutics, SARC: Sarcoma Alliance for Research though Collaboration, Janssen, Advenchen Laboratories, Bayer, NKMax, InhibRx. Grants or contracts from Amgen, Roche, GlaxoSmithKline, Threshold Pharmaceuticals, CytRx Corporation, Ignyta, Immune Design, TRACON Pharma, Karyopharm Therapeutics, SARC: Sarcoma Alliance for Research though Collaboration, Janssen, Advenchen Laboratories, Bayer, InhibRx, NKMax. G Grignani: consultant for Eli Lilly, Novartis, Glaxo, Pharmamar, EISAI, Bayer, Merck. SM Schuetze: consultant – NanoCarrier, UpToDate. Research funding to institution – Adaptimmune, Amgen, Blueprint, Glaxo-SmithKline, Karyopharm. B Vincenzi: Consultant for Pharmamar Eisai, Lilly, Abbott, Novartis, Accord AJ Wagner: consultant for Daiichi-Sankyo, Deciphera, Eli Lilly, Epizyme, NovoCarrier, Mundipharma, and Research Support to My Institution from Aadi Bioscience, Daiichi-Sankyo, Deciphera, Eli Lilly, Karyopharm and Plexxikon. RL Jones: consultant for Adaptimmune, Athenex, Bayer, Boehringer Ingelheim, Blueprint, Clinigen, Eisai, Epizyme, Daichii, Deciphera, Immunedesign, Lilly, Merck, Pharmamar, Springworks, Tracon, Upto Date. J Shah: employee of Karyopharm Therapeutics, Inc. S Shacham: employee of Karyopharm Therapeutics, Inc. M Kauffman: employee of Karyopharm Therapeutics, Inc. RF Riedel: ownership - Limbguard, LLC (Spouse); Institutional Clinical Research Support - AADi, AROG, Blueprint, Daiichi-Sankyo, Deciphera, Glaxo-SmithKline, Karyopharm, Ignyta, Immune Design, NanoCarrier, Oncternal, Philogen, Plexxikon, Roche, Springworks, Tracon; Consultant/Advisor - Bayer, Blueprint, Daiichi-Sankyo, Deciphera, Ignyta, NanoCarrier. S Attia: reports research funding from Desmoid Tumor Research Foundation and research funding to their institution from: AB Science, TRACON Pharma, Bayer, Novartis, Lilly, Immune Design, Karyopharm Therapeutics, Epizyme, Blueprint Medicines, Genmab, CBA Pharma, Merck, Philogen, Gradalis, Deciphera, Takeda, Incyte, Springworks, Adaptimmune, Advenchen Laboratories, Bavarian Nordic, BTG, PTC Therapeutics, GlaxoSmithKline, FORMA Therapeutics. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Peer reviewe

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Antisemitismo canino en las Coplas del perro de Alba

The main objective of this essay is to bring to light and examine the Coplas del perro de Alba, a text that until now has been overlooked by critics, whereas its anti-Semitism allows us to relate it to subsequent texts. Moreover, the poem’s distancing from conventional satirical topoi, its incorporation of the dog as a principal enemy of the Jews, and its corresponding elevation of that animal to an almost heroic level permit its interpretation as an emblem of the problematic social interactions in Spain during that time, and even in the modern era.El objetivo principal de este trabajo es abordar el estudio de las Coplas del perro de Alba, un texto olvidado hasta el momento por la mayor parte de la crítica, en relación con su cariz marcadamente antisemitista, el cual permite relacionarlo con numerosos textos posteriores de nuestra literatura. El alejamiento de los topoi comunes en este tipo de sátiras, la incorporación de la figura del can como principal enemigo de los judíos y la dignificación casi heroica del mismo, hacen de este texto, a pesar de su escaso mérito estético-literario, un testimonio de primera fila de las problemáticas interacciones sociales de la España del momento y, tal vez, también de la época moderna

Public Indiscretion and Courtly Diversion: the Burlesque Letters in Don Quixote II

La carta bufonesca es una modalidad literaria que alcanza su auge en la epoca áurea. Con sus así llamadas ¿epístolas familiares,¿ los bufones oficiales y extraoficiales residentes en las cortes renacentistas sentaron las bases de este festivo recodo de la literatura lúdica. En la segunda parte de Don Quijote, Cervantes se apodera de este subgénero epistolar con el carteo mantenido entre Sancho, Teresa Panza, y la duquesa. Aparte de dibujarnos el matrimonio Panza en plena domesticidad, estas cartas proporcionan una serie de ¿nuevas de corte¿ aldeanas que sirven, entre otras cosas, para desinflar la pompa de los duques. Mi ensayo examina las cartas del Quijote de 1615 bajo la luz de esta tradición para esclarecer un aspecto del humor cervantino desplegado en la novela, y para explorar también la estrecha vinculación ideológico ¿literaria entre Cervantes y la bufonesca¿ la literatura de puro entretenimiento y de risa.

Erotismo felino: Las gatas de Lope de Vega

The affinity between cats and women is an archetype throughout history, and in Golden Age literature certain traits considered to be feline are often projected onto women. Lope de Vega assigns qualities such as independence, lasciviousness, secretiveness and the capacity for treachery onto female cats in La Gatomaquia and other works. By doing so he ingeniously blends human and animal eroticism.La afinidad entre las mujeres y los gatos ha sido un arquetipo a través de la historia, y en la literatura de los siglos de oro ciertos rasgos considerados como felinos se traspasan con frecuencia a las mujeres. Independencia, lubricidad, hermetismo y capacidad de traicionar son cualidades que Lope de Vega asigna a las gatas en La Gatomaquia y otras obras, logrando armonizar con ingenio el erotismo humano y el animal

Images of Deviance in Cervantes's Algiers

Este ensayo se ocupa de una veta inexplorada de la dramaturgia cervantina: el trasfondo sociohistórico y conceptual que contextualiza el retrato de la homosexualidad en el díptico Los tratos de Argel y Los baños de Argel. Partiendo del concepto del deseo elucidado en partes de Quixotic Desire, coadyuvado por estudios contemporáneos acerca de la representación general de la homosexualidad en el Renacimiento e ideas propuestas por Edward Said en torno al ¿Orientalismo¿ universitario, propongo una lectura que permita vislumbrar cómo Cervantes no logra escaparse de la mentalidad que, en última instancia, controla y disciplina la representación en estas comedias